Development, application and future trends of starch-based delivery systems for nutraceuticals: A review

Sun, Chang Q.; Wei, Zihao; Xue, Changhu; Lu, Yang

doi:10.1016/j.carbpol.2023.120675

Cited by 27 publications

(6 citation statements)

References 89 publications

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“…In addition, a variety of nanoparticles made of organic compounds like carbohydrates, proteins, fats, or inorganics such as oxides of silver and titanium are also available for nutraceutical delivery [24]. Other methods may include the use of starch, which is an abundant, low-cost, edible, and biodegradable native polymer that has been recently investigated as a potential base for new delivery systems [40]. Similarly, plant proteins may represent green, alternative nanocarriers thanks to their amphiphilic nature, which makes them compatible with many bioactive compounds to enhance their solubility, stability, and bioavailability [41].…”

Section: Discussionmentioning

confidence: 99%

Liposome-Mediated Delivery Improves the Efficacy of Lisosan G against Retinopathy in Diabetic Mice

Amato,

Melecchi,

Pucci

et al. 2023

Cells

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Nutraceuticals are natural substances whose anti-oxidant and anti-inflammatory properties may be used to treat retinal pathologies. Their efficacy is limited by poor bioavailability, which could be improved using nanocarriers. Lisosan G (LG), a fermented powder from whole grains, protects the retina from diabetic retinopathy (DR)-induced damage. For this study, we tested whether the encapsulation of LG in liposomes (LipoLG) may increase its protective effects. Diabetes was induced in mice via streptozotocin administration, and the mice were allowed to freely drink water or a water dispersion of two different doses of LG or of LipoLG. Electroretinographic recordings after 6 weeks showed that only the highest dose of LG could partially protect the retina from diabetes-induced functional deficits, while both doses of LipoLG were effective. An evaluation of molecular markers of oxidative stress, inflammation, apoptosis, vascular endothelial growth factor, and the blood–retinal barrier confirmed that the highest dose of LG only partially protected the retina from DR-induced changes, while virtually complete prevention was obtained with either dose of LipoLG. These data indicate that the efficacy of LG in contrasting DR is greatly enhanced by its encapsulation in liposomes and may lay the ground for new dietary supplements with improved therapeutic effects against DR.

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Section: Discussionmentioning

confidence: 99%

Liposome-Mediated Delivery Improves the Efficacy of Lisosan G against Retinopathy in Diabetic Mice

Amato,

Melecchi,

Pucci

et al. 2023

Cells

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“…In vitro models often oversimplify biological systems, which can lead to a failure to capture the true complexity of the interactions between nutraceuticals and human tissues. In vitro models can produce varying results, making it difficult to determine the true therapeutic potential of a nutraceutical. ,, The OOC model can overcome the shortcomings of conventional traditional in vitro models due to its dynamic microphysiological structure. Figure depicts the parameters essential to model an OOC system for nutraceutical testing.…”

Section: Challenges and Successmentioning

confidence: 99%

“…When modeling the OOC system, the cell type, microfluidic design carrying the proper nutrient delivery and oxygenation, ECM composition, shear stress, real-time sensor to monitor cell viability, proliferation, metabolic activity, readouts, and validation of results should be considered as shown in Figure . − Selecting the appropriate cell line, whether an induced pluripotent stem cell (iPSC) line or a primary cell line, is crucial for replicating the necessary cell–cell interactions to represent human biology accurately. Failure to incorporate specific cell lines for particular organs may lead to false positive results.…”

Section: Types Of Ooc Models For Nutraceutical Testingmentioning

confidence: 99%

“…In vitro models can produce varying results, making it difficult to determine the true therapeutic potential of a nutraceutical. 101 , 104 , 109 The OOC model can overcome the shortcomings of conventional traditional in vitro models due to its dynamic microphysiological structure. Figure 6 depicts the parameters essential to model an OOC system for nutraceutical testing.…”

Section: Challenges and Successmentioning

confidence: 99%

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Organ-on-Chip: Advancing Nutraceutical Testing for Improved Health Outcomes

Farooqi,

Kang,

Choi

2023

ACS Omega

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The recent global wave of organic food consumption and the vitality of nutraceuticals for human health benefits has driven the need for applying scientific methods for phytochemical testing. Advanced in vitro models with greater physiological relevance than conventional in vitro models are required to evaluate the potential benefits and toxicity of nutraceuticals. Organ-onchip (OOC) models have emerged as a promising alternative to traditional in vitro models and animal testing due to their ability to mimic organ pathophysiology. Numerous studies have demonstrated the effectiveness of OOC models in identifying pharmaceutically relevant compounds and accurately assessing compound-induced toxicity. This review examines the utility of traditional in vitro nutraceutical testing models and discusses the potential of OOC technology as a preclinical testing tool to examine the biomedical potential of nutraceuticals by reducing the need for animal testing. Exploring the capabilities of OOC models in carrying out plant-based bioactive compounds can significantly contribute to the authentication of nutraceuticals and drug discovery and validate phytochemicals medicinal characteristics. Overall, OOC models can facilitate a more systematic and efficient assessment of nutraceutical compounds while overcoming the limitations of current traditional in vitro models.

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“…The addition of anthocyanin extracts can prevent the cracking and brittleness of starch film, increase the flexibility and ductility of starch film, and allow starch film to demonstrate rich color changes with changes in pH value. Moreover, starch can encapsulate anthocyanins through electrostatic interactions, hydrogen bonding, and hydration, which could enhance the stability of anthocyanins [63,64]. Additionally, the branching structure of starch molecules has more voids and adsorption sites, which would enhance the encapsulation of anthocyanins.…”

Section: Starch-based Filmmentioning

confidence: 99%

Active and Intelligent Biodegradable Packaging Based on Anthocyanins for Preserving and Monitoring Protein-Rich Foods

Zhu,

Zhong,

Wang

et al. 2023

Foods

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Currently, active and intelligent packaging has been developed to solve the spoilage problem for protein-rich foods during storage, especially by adding anthocyanin extracts. In such a film system, the antioxidant and antibacterial properties were dramatically increased by adding anthocyanins. The physicochemical properties were enhanced through interactions between the active groups in the anthocyanins and reactive groups in the polymer chains. Additionally, the active and intelligent film could monitor the spoilage of protein-rich foods in response to pH changes. Therefore, this film could monitor the sensory acceptance and extend the shelf life of protein-rich foods simultaneously. In this paper, the structural and functional properties of anthocyanins, composite actions of anthocyanin extracts and biomass materials, and reinforced properties of the active and intelligent film were discussed. Additionally, the applications of this film in quality maintenance, shelf-life extension, and quality monitoring for fresh meat, aquatic products, and milk were summarized. This film, which achieves high stability and the continuous release of anthocyanins on demand, may become an underlying trend in packaging applications for protein-rich foods.

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Development, application and future trends of starch-based delivery systems for nutraceuticals: A review

Cited by 27 publications

References 89 publications

Liposome-Mediated Delivery Improves the Efficacy of Lisosan G against Retinopathy in Diabetic Mice

Liposome-Mediated Delivery Improves the Efficacy of Lisosan G against Retinopathy in Diabetic Mice

Organ-on-Chip: Advancing Nutraceutical Testing for Improved Health Outcomes

Active and Intelligent Biodegradable Packaging Based on Anthocyanins for Preserving and Monitoring Protein-Rich Foods

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