Development and validation of UV-spectrophotometric methods for the determination of sumatriptan succinate in bulk and pharmaceutical dosage form and its degradation behavior under varied stress conditions

Prashanth, Kudige N.; Basavaiah, K.; Xavier, Cijo M.

doi:10.1016/j.jaubas.2013.03.004

Cited by 12 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Application to assay of commercial samples: The proposed analytical procedure has been used for the analysis of pharmaceutical dosage forms of the investigated drugs and results obtained were compared by those of the described ones [3,5,8,11] by applying student's t-test and F-test at the 95% confidence level [38]. No significant difference was noticed between the values of the suggested and reported assays indicating high accuracy as well as good precision in the assay of the investigated compounds in their dosage forms (Table 5).…”

Section: Resultsmentioning

confidence: 99%

“…[1,2]. Different analytical techniques were reported for their determination in different matrices including spectrophotometry [3][4][5][6][7][8], spectrofluorimetry [9][10][11], conductometry [12] and HPLC [13][14][15][16][17][18][19][20]. The complex formation that occurs between a lot of drugs and Eosin Y as an ion pairing agent has been considerably investigated using spectrophotometric and spectrofluorimetric assay of such drugs with or without using of metal [21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Validation of Rapid and Sensitive Spectrofluorimetric Assay for Determination of Four Triptans in Pure and Dosage Forms; Application to Human Plasma and Content Uniformity Testing

MA¹,

MA²

2016

Pharm Anal Acta

View full text Add to dashboard Cite

A sensitive, simple, rapid and reliable spectrofluorimetric assay was developed for the assay of definite antimigraine drugs namely; Almotriptan malate, Rizatriptan benzoate, Sumatriptan succinate and Zolmitriptan in their pharmaceutical preparations and biological fluid. The suggested procedure was established on determination of the quenching process resulting from the action of the studied drugs on the native fluorescence of Eosin Y via developing of a binary complex reaction between the cited antimigraine preparations and Eosin Y in 0.2 M acetate buffer (pH.3.5). Under the optimized experimental conditions, the relative fluorescence capacity was determined at λ ex =301.3 nm and λ em =542.8 nm. The calibration graphs were linear through extent from 0.07-1.0, 0.20-1.0, 0.2-1.0 and 0.1-1.0 µg/mL, for Almotriptan malate, Rizatriptan benzoate, Sumatriptan succinate and Zolmitriptan, respectively. The detection limits were 0.019, 0.041, 0.055 and 0.032 µg/mL while quantitation limits were 0.059, 0.125, 0.168 and 0.096 µg/mL for Almotriptan malate, Rizatriptan benzoate, Sumatriptan succinate and Zolmitriptan, respectively. The suggested assay has been validated according to ICH and USP guidelines and favorably has been applied to assay of cited drugs in their dosage forms and content uniformity testing. The high sensitivity of the developed assay allowed quantification of the studied antimigraine drugs in human plasma.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Validation of Rapid and Sensitive Spectrofluorimetric Assay for Determination of Four Triptans in Pure and Dosage Forms; Application to Human Plasma and Content Uniformity Testing

MA¹,

MA²

2016

Pharm Anal Acta

View full text Add to dashboard Cite

show abstract

“…Triptans' potential mechanisms of action in migraine include cerebral vasoconstriction, decrease of neuropeptide and protein extravasation across dural arteries, and central inhibition of impulse transmission within the trigeminovascular system. 7,8 Triptans' major function in migraine, in our opinion, is to constrict dilated cranial extracerebral blood arteries, which is a 5-HT1B impact. When pure 5-HT1D receptor agonists have been produced and tested for efficacy in migraine, the potential contribution of triptans' neuronal impact can be assessed.…”

Section: Introduction Sumatriptan Succinate (Sulphur Atom)mentioning

confidence: 95%

New Smartphone based Colorimetric Method Development and validation for the Drugs containing Nitrogen, Sulphur and Phosphorus in Bulk and Tablet Dosage Form

Choudhary

Choksi

Mashru

2022

J. Drug Delivery Ther.

View full text Add to dashboard Cite

A method for determining the concentration of coloured compounds in a solution is colorimetry. The intensity of the colour is related to the chemical concentration being measured. Because of their low cost and ability to collect, store, and interpret data all in one device, smartphone-based colorimetry has increased in popularity as an analytical tool. The camera on the phone is used as a detector in smartphone colorimetry. Both the smartphone colorimetric method and the UV method relied on the detection of colour intensity as concentration rose. Distinct oxidation states of ammonium metavanadate generate different colours depending on the oxidation state. The +5-oxidation state appears yellow, the +4-oxidation state appears blue, the +3-oxidation state appears green, and the +2-oxidation state appears purple. The ammonium metavanadate reagent is orange red in colour, but when it combines with pharmaceuticals that contain nitrogen, phosphorus, or sulphur in their structure, it turns green. The developed approach for all of the drugs in this article is linear. The colour intensity increases as the concentration of API increases. All of the photos were captured on a smartphone and analysed with photometrix PRO software. The photometrix PRO application turns an image to an RGB histogram, and it also includes regression models. The percent RSD for all three drugs was less than 2 employing Photometrix PRO and UV method. Using a statistical method called a two-paired test, the results reveal that both procedures are equally significant for all three drugs. Keywords: Uv spectrophotometry, Photometrix PRO, RGB Histogram, Sumatriptan Succinate, Gemifloxacin, Tenofovir disoproxil fumarate

show abstract

“…Several analytical techniques have been developed for the quantitative determination of sumatriptan, including voltammetry [4,5], ultraviolet (UV) spectroscopy [6], and liquid chromatography (LC) coupled with UV [7][8][9], fluorescence [10], electrochemical [11,12], and mass spectrometric (MS) detectors [3,[13][14][15][16]. Electrochemical, UV-vis, and fluorescent spectroscopic techniques can be advantageous as they are fast, simple, and require inexpensive instruments.…”

Section: Introductionmentioning

confidence: 99%

“…Electrochemical, UV-vis, and fluorescent spectroscopic techniques can be advantageous as they are fast, simple, and require inexpensive instruments. However, these methods are limited by sensitivity and/or specificity and often require a large amount of sample, which is unsuitable for analyzing trace amounts of sumatriptan in human serum samples [4][5][6][10][11][12]. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been demonstrated as a routine technique for applications in pharmaceutical analyses that affords high throughput, good sensitivity, and selectivity.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Simple Analysis of Sumatriptan and its Application in Bioequivalence Study

Wichitnithad

Nantaphol²,

Vicheantawatchai³

et al. 2020

Pharmaceuticals

View full text Add to dashboard Cite

This work demonstrated a sensitive, selective, and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantitation of sumatriptan in human plasma samples. Terazosin was used as an internal standard to minimize the variability during sample processing and detection. Sample cleanup prior to chromatographic analysis was accomplished by liquid-liquid extraction (LLE) with tert-butyl methyl ether (t-BME). The separation was performed on a reversed-phase Symmetry® C18 column (150 × 4.6 mm i.d., 5 µm) under a gradient mode, using a 0.2% formic acid aqueous solution and acetonitrile at a flow rate of 0.5 mL/min. Sumatriptan (m/z 296.26→251.05) and terazosin (m/z 388.10→290.25) were quantified using a triple quadrupole mass spectrometer, operating in the multiple reaction monitoring (MRM) under the positive ion mode. The method was fully validated following US-FDA and EMA guidelines. The LC-MS/MS assay had a calibration range of 0.5–50.0 ng/mL. The assay was precise and accurate with a between-run precision of <9.51%, and between-run accuracy between −7.27 to 8.30%. The developed method was subsequently applied in the determination of plasma concentration-time profile of a sumatriptan 50-mg tablet following oral administration in healthy volunteers.

show abstract

Development and validation of UV-spectrophotometric methods for the determination of sumatriptan succinate in bulk and pharmaceutical dosage form and its degradation behavior under varied stress conditions

Cited by 12 publications

References 15 publications

Validation of Rapid and Sensitive Spectrofluorimetric Assay for Determination of Four Triptans in Pure and Dosage Forms; Application to Human Plasma and Content Uniformity Testing

Validation of Rapid and Sensitive Spectrofluorimetric Assay for Determination of Four Triptans in Pure and Dosage Forms; Application to Human Plasma and Content Uniformity Testing

New Smartphone based Colorimetric Method Development and validation for the Drugs containing Nitrogen, Sulphur and Phosphorus in Bulk and Tablet Dosage Form

Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Simple Analysis of Sumatriptan and its Application in Bioequivalence Study

Contact Info

Product

Resources

About