Development and Validation of Uv Spectroscopic Method of Paliperidone Palmitate in Bulk and Its Application for Drug Loading and Entrapment Efficiency Analysis of Long-Acting Injectable Microspheres
Abstract:Objective: The objective of the current study was to develop simple, precise and cost-effective ultraviolet (UV) spectroscopic method for estimation of paliperidone palmitate (PP) as a bulk and in the polymeric depot dosage form.
Methods: UV spectrophotometer with quartz sample cells and spectral manager software was used for analysis samples. 20 % Methanol in Mili-Q-Water was used as a solvent for the sample and standard preparations. Method validation was carried out as per ICH Q2 (R1) guidelines. Stre… Show more
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