Development and Validation of UPLC-MS/MS Method for the Determination of Aripiprazole in Rat Plasma Using Liquid-Liquid Extraction: Pharmacokinetic and Bioequivalence Application
Abstract:A selective, simple, sensitive and rapid ultra-performance liquid chromatographic tandem mass
spectrometric (UPLC-MS/MS) method for the detection of aripiprazole in rat plasma has been developed
and validated using aripiprazole-D8 as internal standard (IS). A simple single step sample preparation
process was accomplished by liquid-liquid extraction (LLE). The post-treatment samples were
chromato-graphed and analyzed on a UPLC bridged ethyl hybrid (BEH) C-18 column using mobile
phase composition of acetonitrile… Show more
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