Development and Validation of Two Self-Reported Tools for Insulin Resistance and Hypertension Risk Assessment in A European Cohort: The Feel4Diabetes-Study

Abstract

Early identification of type 2 diabetes mellitus (T2DM) and hypertension (HTN) risk may improve prevention and promote public health. Implementation of self-reported scores for risk assessment provides an alternative cost-effective tool. The study aimed to develop and validate two easy-to-apply screening tools identifying high-risk individuals for insulin resistance (IR) and HTN in a European cohort. Sociodemographic, lifestyle, anthropometric and clinical data obtained from 1581 and 1350 adults (baseline data from the Feel4Diabetes-study) were used for the European IR and the European HTN risk assessment index respectively. Body mass index, waist circumference, sex, age, breakfast consumption, alcohol, legumes and sugary drinks intake, physical activity and sedentary behavior were significantly correlated with Homeostatic Model Assessment of IR (HOMA-IR) and/or HTN and incorporated in the two models. For the IR index, the Area Under the Curve (AUC), sensitivity and specificity for identifying individuals above the 75th and 95th of HOMA-IR percentiles were 0.768 (95%CI: 0.721–0.815), 0.720 and 0.691 and 0.828 (95%CI: 0.766–0.890), 0.696 and 0.778 respectively. For the HTN index, the AUC, sensitivity and specificity were 0.778 (95%CI: 0.680–0.876), 0.667 and 0.797. The developed risk assessment tools are easy-to-apply, valid, and low-cost, identifying European adults at high risk for developing T2DM or having HTN.

Risk of Typical Diabetes-Associated Complications in Different Clusters of Diabetic Patients: Analysis of Nine Risk Factors

“…Additionally, we cannot draw conclusions as to whether adequate diabetes therapy is related to changes in the risk of complications. Another limitation is that we had no access to data on lifestyle habits such as physical activity and nutritional data, which are closely related to the development of insulin resistance and diabetes mellitus [ 37 ].…”

Anthropometric cut-points for discriminating diabetes and the metabolic syndrome among Arabs and Asians: the Kuwait Diabetes Epidemiology Program

“…Prognostic risk assessment tools for early identification of T2D and CVD exist. These include, but are not limited to, the Framingham risk assessment tool (12) , Finish diabetes risk score (FINDRISK) (13) , systematic coronary risk evaluation (SCORE) risk charts (14) , UK prospective diabetes study (UKPDS) risk engine (15) , European IR Risk Index and European HTN Risk Index (16) . However, the prospective population used to design these risk assessment tools did not include the Kuwaiti population.…”

Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signaling pathways in vitro and in vivo

“…2011). Moreover, insulin resistance is closely related to several cardiovascular diseases, such as myocardial infarction, hypertension and heart failure (Kanellakis et al, 2020; Wiebe et al, 2019; Uddin et al, 2019). Clinical follow-up studies have demonstrated that elevated serum uric acid is a strong independent risk factor for insulin resistance (Han et al, 2017), and ours and others’ previous studies have revealed that high uric acid (HUA) evokes insulin resistance in cardiomyocytes, adipocytes, muscle and liver (Zhi et al, 2016; Su et al, 2020; Zhu et al, 2014; Yuan et al, 2017).…”