Development and validation of the Michigan Chronic Disease Simulation Model (MICROSIM)
James F. Burke,
Luciana L. Copeland,
Jeremy B. Sussman
et al.
Abstract:Strategies to prevent or delay Alzheimer’s disease and related dementias (AD/ADRD) are urgently needed, and blood pressure (BP) management is a promising strategy. Yet the effects of different BP control strategies across the life course on AD/ADRD are unknown. Randomized trials may be infeasible due to prolonged follow-up and large sample sizes. Simulation analysis is a practical approach to estimating these effects using the best available existing data. However, existing simulation frameworks cannot estimat… Show more
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