Development and validation of the Composite Asthma Severity Index—an outcome measure for use in children and adolescents

Wildfire, Jeremy; Gergen, Peter J.; Sorkness, Christine A.; Mitchell, Herman; Calatroni, Agustin; Kattan, Meyer; Szefler, Stanley J.; Teach, Stephen J.; Bloomberg, Gordon R.; Wood, Robert A.; Liu, Andrew H.; Pongracic, Jacqueline A.; Chmiel, James F.; Conroy, Kathleen; Rivera-Sanchez, Yadira; Busse, William W.; Morgan, Wayne J.

doi:10.1016/j.jaci.2011.12.962

Cited by 126 publications

(105 citation statements)

References 21 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…Asthma classification was based on physician diagnosis, and confirmed by electronic medical records. Asthma severity was classified using the Composite Asthma Severity Index (16), based on self-reported frequency of symptoms and medication use. Asthma control was classified based on responses to the Asthma Control Test questionnaire (17).…”

Section: Study Populationmentioning

confidence: 99%

Inflammation, Metabolic Dysregulation, and Pulmonary Function among Obese Urban Adolescents with Asthma

Rastogi¹,

Fraser²,

Oh³

et al. 2015

Am J Respir Crit Care Med

160

170

View full text Add to dashboard Cite

Rationale: Insulin resistance and low high-density lipoprotein (HDL) are associated with pulmonary morbidity, including asthma, but the underlying mechanisms are not well elucidated.Objectives: To investigate whether systemic inflammation underlies the association of metabolic abnormalities with pulmonary function among urban adolescents.Methods: Th-cell responses and monocyte subsets, and their association with serum homeostatic model assessment of insulin resistance (HOMA-IR) and HDL, and pulmonary function were quantified in 168 adolescents, including 42 obese subjects with asthma, 42 normal-weight subjects with asthma, 40 obese subjects without asthma, and 44 healthy control subjects. Th-cell responses (Th1 [CD4 ) monocytes, and their C-C chemokine receptor type-2 (CCR2) expression were quantified by flow cytometry.Measurements and Main Results: Th1/Th2 ratio to all three stimuli was higher in obese subjects with asthma than normal-weight subjects with asthma and directly correlated with HOMA-IR. Classical monocytes inversely associated with Th1/Th2 ratio to phytohemagglutinin (r = 20.43; P = 0.01) and directly with Asthma Control Test score (b = 1.09; P = 0.04), while patrolling monocytes correlated with Composite Asthma Severity Index score (b = 1.11; P = 0.04) only among obese subjects with asthma. HDL was inversely associated with patrolling monocytes and directly associated with CCR2 expression on resident monocytes. CCR2 expression on patrolling monocytes predicted residual volume (RV), RV/TLC ratio, and FRC, after adjusting for HDL, but not after adjusting for body mass index. Association of Th1/Th2 ratio with RV, FRC, and inspiratory capacity was attenuated after adjusting for HOMA-IR.Conclusions: Th1 polarization and monocyte activation among obese subjects with asthma correlates with metabolic abnormalities. Association of monocyte activation with pulmonary function is mediated by body mass index, whereas that of Th1 polarization is mediated by insulin resistance.

show abstract

Section: Study Populationmentioning

confidence: 99%

Inflammation, Metabolic Dysregulation, and Pulmonary Function among Obese Urban Adolescents with Asthma

Rastogi¹,

Fraser²,

Oh³

et al. 2015

Am J Respir Crit Care Med

160

170

View full text Add to dashboard Cite

show abstract

“…Therefore, these composite scores appear to underestimate the level of asthma control as defined by GINA [70]. Recently, two composite asthma control scores have been developed that include exacerbations: the Test for Respiratory and Asthma Control in Kids (TRACK) and the Composite Asthma Severity Index (CASI) [71,72].…”

Section: Clinical Tools: Symptoms Exacerbations and Qolmentioning

confidence: 99%

Monitoring asthma in children

et al. 2015

Self Cite

View full text Add to dashboard Cite

The goal of asthma treatment is to obtain clinical control and reduce future risks to the patient. To reach this goal in children with asthma, ongoing monitoring is essential. While all components of asthma, such as symptoms, lung function, bronchial hyperresponsiveness and inflammation, may exist in various combinations in different individuals, to date there is limited evidence on how to integrate these for optimal monitoring of children with asthma. The aims of this ERS Task Force were to describe the current practise and give an overview of the best available evidence on how to monitor children with asthma.22 clinical and research experts reviewed the literature. A modified Delphi method and four Task Force meetings were used to reach a consensus.This statement summarises the literature on monitoring children with asthma. Available tools for monitoring children with asthma, such as clinical tools, lung function, bronchial responsiveness and inflammatory markers, are described as are the ways in which they may be used in children with asthma. Management-related issues, comorbidities and environmental factors are summarised.Despite considerable interest in monitoring asthma in children, for many aspects of monitoring asthma in children there is a substantial lack of evidence. @ERSpublications ERS statement summarising and discussing the available literature on monitoring children with asthma

show abstract

“…• Test for Respiratory and Asthma Control in Kids (TRACK) [72][73][74] • Composite Asthma Severity Index (CASI) 75 The results of these various tests correlate to some extent with each other and with the GINA classification of symptom control. Box 2-3 provides more details about assessing asthma control in children.…”

Section: Asthma Symptom Control Tools For Children 6-11 Years Of Agementioning

confidence: 99%

Mortality in Asthma-Chronic Obstructive Pulmonary Disease Overlap in the United States

Kumbhare

Strange

2018

Southern Medical Journal

View full text Add to dashboard Cite

Development and validation of the Composite Asthma Severity Index—an outcome measure for use in children and adolescents

Cited by 126 publications

References 21 publications

Inflammation, Metabolic Dysregulation, and Pulmonary Function among Obese Urban Adolescents with Asthma

Inflammation, Metabolic Dysregulation, and Pulmonary Function among Obese Urban Adolescents with Asthma

Monitoring asthma in children

Mortality in Asthma-Chronic Obstructive Pulmonary Disease Overlap in the United States

Contact Info

Product

Resources

About