Development and Validation of the Mini-Osteoporosis Quality of Life Questionnaire (OQLQ) in Osteoporotic Women with Back Pain due to Vertebral Fractures. Osteoporosis Quality of Life Study Group

Abstract

The objective of the study was to evaluate a shortened osteoporosis quality of life questionnaire (OQLQ) in osteoporotic women with back pain due to vertebral fractures. From the longer 30-item OQLQ (four to nine items per domain) we created the mini-OQLQ by choosing the two items with the highest impact in each of five domains (symptoms, physical function, activities of daily living, emotional function, leisure). We administered the OQLQ, the Sickness Impact Profile, the SF-36 and the Brief Pain Index to patients at baseline, after 2 weeks and after 6 months. The intraclass correlations between baseline and the 2-week follow-up for the five mini-OQLQ domains ranged from 0.72 to 0.86. Cross-sectional correlations between the domains of the mini-OQLQ and other health instruments were moderate to large (0.35-0.80) and greater than predicted. The mini-OQLQ items showed moderate to large correlations with items omitted from the shortened questionnaire (0. 44-0.88). Correlations between the OQLQ domains and the other three instruments were greater than those of the mini-OQLQ, and partial correlations between OQLQ items omitted from the mini-OQLQ and the other three instruments after considering mini-OQLQ items were substantial (0.19-0.71) and statistically significant. Sample sizes of less than 200 per group should be required to detect minimally important differences in parallel-group clinical trials. Longitudinal correlations between the mini-OQLQ and the other measures were often significant but generally lower than predicted (0.10-0.49). The partial correlations revealed that the omitted items explained a significant portion of the longitudinal variance in each domain. We conclude that in a selected group of patients with back pain caused by vertebral fractures, the mini-OQLQ demonstrated good discriminative and adequate evaluative properties. The mini-questionnaire should be useful in clinical settings.

Psychometric properties evaluation of the quality of life Questionnaire of the European foundation for Osteoporosis in Arabic population

“…Since the sum of physical, social, and mental functioning determines quality of life; its assessment plays an increasingly important role in clinical studies and particularly as an outcome measure of clinical trials. Several instruments for measuring the quality of life of patients with OP have been developed [3][4][5], but none of these were validated in Arabic language. One of these tools is the QUALEFFO that has been developed by a working party of the European Foundation for OP for patients with VF [6,7].…”

Clinical Effects of a 6-Month Treatment Course of Ibandronate, Vitamin D, and Calcium in Postmenopausal Women from Central America: Results of a Multinational, Prospective Pilot Study

“…HRQoL was studied by the mini-Osteoporosis Quality of Life Questionnaire (mini-OQLQ) [13]. Total and subdomain scores related to emotional functioning (items No.…”

Validity and reliability of the Farsi version of the ECOS-16 questionnaire for females with osteoporosis

“…While clinicians and researchers may apply a variety of questionnaires to assess health-related quality of life (12)(13)(14)(15), the length of these instruments and the time they take to complete may limit their use. Consideration of greater efficiency, decreased burden on the respondent and clinical feasibility has led to the development of shorter questionnaires (16 The score for each item ranges from 1 to 5.…”