“…The main factors associated with unemployment and difficulties related to the fitness for work are cognitive disorders, depression, anxiety, pain, fatigue and type of employment11,12,13,14,15,16,17 ) . With regard to the factors and/or disease manifestations that most frequently were associated with difficulties in performing working tasks (that consequently raise problems in issuing a fitness for work judgment without limitations or prescriptions) they included, progressive disease course, increasing age, physical disability, higher levels of pain and fatigue, depression, anxiety and cognitive impairments/disorders10,11,12,13,14, 17,18,19,20,21,22,23,24,25 ) .…”