Development and validation of the Alzheimer's prevention beliefs measure in a multi-ethnic cohort—a behavioral theory approach

Seifan, Alon; Ganzer, Christine A.; Vermeylen, Françoise; Parry, Stephen; Zhu, Jifeng; Lyons, Abigail; Isaacson, Richard S.; Kim, Sarang

doi:10.1093/pubmed/fdw145

Cited by 9 publications

(13 citation statements)

References 28 publications

(37 reference statements)

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“…More research is needed to get insight in the specific barriers for changing smoking behaviour. In general, our findings are consistent with previous studies [ 16 , 17 ].…”

Section: Discussionsupporting

confidence: 94%

“…However, Kim et al (2014) only found significant age differences in males, but not in females [ 14 ]. Furthermore, a few studies conducted in Australia and the United States of America investigated how these health beliefs influence the intention to engage in dementia risk reduction behaviours and showed that age, perceived benefits and barriers, self-efficacy and knowledge about dementia risk reduction are associated with the intention to adopt a healthy lifestyle for dementia risk reduction in general [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Knowledge, health beliefs and attitudes towards dementia and dementia risk reduction among the Dutch general population: a cross-sectional study

et al. 2021

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Background Positive health beliefs and attitudes towards dementia and dementia risk reduction may encourage adopting a healthy behaviour. Therefore, we aimed to investigate the knowledge, health beliefs and attitudes towards dementia and dementia risk reduction among the Dutch general population and its association with the intention to change health behaviours. Methods A random sample of Dutch residents (30 to 80 years) was invited to complete an online survey. We collected data on knowledge, health beliefs and attitudes towards dementia (risk reduction) and the intention to change health behaviours. Multivariable logistic regression analyses were used to obtain effect estimates. Results Six hundred fifty-five participants completed the survey. In general, participants had insufficient knowledge about dementia and dementia risk reduction. Participants had relatively high scores on general health motivation and perceived benefits, but low scores on perceived susceptibility, perceived severity, perceived barriers, cues to action and self-efficacy. Individuals with higher scores on perceived benefits and cues to action had more often the intention to change their behaviour with regard to physical activity (OR = 1.33, 95%-CI:1.11–1.58; OR = 1.13, 95%-CI:1.03–1.24, respectively) and alcohol consumption (OR = 1.30, 95%-CI:1.00–1.69; OR = 1.17, 95%-CI:1.02–1.35, respectively). Younger excessive alcohol consumers with higher perceived severity scores had more often the intention to change their alcohol consumption behaviour (OR = 2.70, 95%-CI:1.04–6.97) compared to older excessive alcohol consumers. Opposite results were found for middle-aged excessive alcohol consumers (OR = 0.81, 95%-CI:0.67–0.99). Individuals who perceived more barriers had more often the intention to change their diet (OR = 1.10, 95%-CI:1.01–1.21), but less often the intention to change their smoking behaviour (OR = 0.78, 95%-CI:0.63–0.98). Moreover, less educated individuals with higher perceived benefits scores had less often the intention to change their diet (OR = 0.78, 95%-CI:0.60–0.99), while highly educated individuals with higher perceived benefits scores had more often the intention to change their diet (OR = 1.41, 95%-CI:1.12–1.78). Conclusions The knowledge, beliefs and attitudes towards dementia and dementia risk reduction among the Dutch general population is insufficient to support dementia risk reduction. More education about dementia and dementia risk reduction is needed to improve health beliefs and attitudes towards dementia and dementia risk reduction in order to change health behaviour.

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“…More research is needed to get insight in the specific barriers for changing smoking behaviour. In general, our findings are consistent with previous studies [ 16 , 17 ].…”

Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Knowledge, health beliefs and attitudes towards dementia and dementia risk reduction among the Dutch general population: a cross-sectional study

et al. 2021

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“…First, scales measuring constructs of interest were reviewed from the existing literature. Items pulled from existing scales assessing experience with and concern about AD [ 9 ], perceived health, health locus of control [ 10 ], brain health social norms [ 11 ], research attitudes [ 12 ], and chronic experiences of perceived discrimination due to race, ethnicity, gender, age, or other interpersonal characteristics [ 13 ] were included and modified for telephone administration. New items were developed to assess willingness to learn biomarker results and potential positive or negative reactions to learning hypothetical positive/high-risk biomarker results.…”

Section: Methodsmentioning

confidence: 99%

Anticipated reactions to learning Alzheimer’s disease biomarker results

et al. 2022

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Introduction We developed the Alzheimer’s Biomarker Survey to assess willingness to enroll in biomarker studies that disclose results and anticipated reactions to an elevated biomarker result. Methods Participants included cognitively unimpaired adults enrolled in longitudinal AD studies (n = 334, mean age = 64.8 ± 7.7, 44% non-Hispanic Black or African American). Exploratory and confirmatory factor analyses determined the latent structure comprising anticipated reactions to learning AD biomarker results. Measurement invariance was tested across racial groups. Results Two models comprising behavior change and psychological impact fit well for the total sample and the two racial groups. The 2-factor behavior change model assessed constructs of planning and dementia risk-reduction. The 3-factor psychological impact model assessed constructs of distress, cognitive symptoms, and stigma. Both models exhibited measurement invariance across racial groups. Discussion The 28-item Anticipated Reactions to AD Biomarker Disclosure scale is a reliable and valid measure of anticipated reactions when communicating AD biomarker results to research participants.

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“…By taking advantage of recent advances in communication practices and technology as a whole, we believe that online interventions can facilitate the recruitment process 4 . Investigating the possible barriers that exist between the public and their willingness to participate in AD education, screening, clinical trials, and risk reduction is essential for the advancement of therapeutic interventions in the field of AD 14 . It is also imperative to consider the effect of recruitment efforts on participant engagement and retention in clinical trials 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Upon joining AlzU.org, participants completed a pre‐course (baseline) comprehensive questionnaire covering demographics, as well as behavioral, lifestyle, and risk assessment measures including a validated scale evaluating the stages of change of behavioral intent related to AD prevention 14 . After completing the baseline questionnaire, participants were redirected to the AlzU.org lesson menu.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of online education for recruitment to an Alzheimer's disease prevention clinical trial

Saif

Berkowitz

Tripathi

et al. 2020

A&D Transl Res & Clin Interv

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Introduction Low awareness of Alzheimer's disease (AD) clinical trials is a recruitment barrier. To assess whether online education may affect screening rates for AD prevention clinical trials, we conducted an initial prospective cohort study (n = 10,450) and subsequent randomized study (n = 351) using an online digital tool: AlzU.org. Methods A total of 10,450 participants were enrolled in an initial cohort study and asked to complete a six‐lesson course on AlzU.org, as well as a baseline and 6‐month follow‐up questionnaire. Participants were stratified into three groups based on lesson completion at 6 months: group 1 (zero to one lesson completed), group 2 (two to four lessons), and group 3 (five or more lessons). For the subsequent randomized‐controlled trial (RCT), 351 new participants were enrolled in a six‐lesson course (n = 180) versus a time‐neutral control (n = 171). Screening and enrollment in the Anti‐Amyloid Treatment in Asymptomatic AD (A4) clinical trial were reported via the 6‐month questionnaire and are the primary outcomes. Results Cohort: 3.9% of group 1, 5% of group 2, and 8.4% of group 3 screened for the A4 trial. Significant differences were found among the groups (P < 0.001). Post hoc analyses showed differences in A4 screening rates between groups 1 and 3 (P < 0.001) and groups 2 and 3 (P = 0.0194). There were no differences in enrollment among the three groups. RCT: 2.78% of the intervention group screened for A4 compared to 0% of controls (P = 0.0611). Discussion Online education via the AlzU.org digital tool may serve as an effective strategy to supplement clinical trial recruitment.

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Development and validation of the Alzheimer's prevention beliefs measure in a multi-ethnic cohort—a behavioral theory approach

Cited by 9 publications

References 28 publications

Knowledge, health beliefs and attitudes towards dementia and dementia risk reduction among the Dutch general population: a cross-sectional study

Knowledge, health beliefs and attitudes towards dementia and dementia risk reduction among the Dutch general population: a cross-sectional study

Anticipated reactions to learning Alzheimer’s disease biomarker results

Effectiveness of online education for recruitment to an Alzheimer's disease prevention clinical trial

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