Development and validation of stability indicating RP-HPLC method for estimation of roflumilast in tablet dosage form

Avula, Pooja; Rajitha, Galla; Adepu, Geetha Susmita; Vemanaboina, Hari Babu; Tyagarajan, Sivaranjani

doi:10.5958/0974-360x.2021.00153.0

Cited by 3 publications

(1 citation statement)

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“…A study has been conducted on the "analytical procedures" used to determine "ESC and ETZ" as a single and multi-component. Single ESC UV-spectrophotometry [9], HPLC (High Performance Liquid Chromatography) [10][11][12][13], HPTLC [14]and single ETZ UV-spectrophotometry [15], HPLC [16,17]The combined study of ESC and ETZ of UV-spectrophotometry [18], HPLC [19], UPLC [20]. Based on the review of the literature, clearly stated that the combination of ESC and ETZ by HPTLC does not make a method.…”

Section: Introductionmentioning

confidence: 99%

Eco-friendly based stability-indicating HPTLC technique for the determination of Escitalopram and Etizolam by employing quality by design approach

Perumal

Krishnan

Lakshmi

2024

AChrom

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The two chemical components Escitalopram (ESC) and Etizolam (ETZ) are beneficial for the health of individuals because it helps to treat anxiety. The study mainly illustrated that a green approach is essential in the medical sector with the help of “Green Analytical quality by design”. According to AQbD, the techniques of HPTLC have become eco-friendly, and decided to use “ESC” and “ETZ”. Hence, ethanol and phosphate buffer pH 3.5 adjusted with 1% “orthophosphoric acid”. After the retardation factor, the product ESC was found at 0.34 min and ETZ was found at 0.53 min. The linearity of ETZ the range varies from 300 to 1800 μg mL−1 and for ESC it varies from 100 to 600 μg mL−1. The validation parameter of R2 Values ranged from 0.9997 to 0.9994 for both ESC and ETZ. The study also demonstrated that different other methods were also useful for the medical sector to make it more convenient and eco-friendly. Some of those approaches are “GAPI”, “AGMS”, “NEMI”, and “AGREE”. The outcome of the study helped to find that the technique “HPTLC” is a green analytic design that helps to maintain the stability of the medicine and it was also approved as a quality design and also a novel approach in the pharmaceutical sector.

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