2021
DOI: 10.1016/j.microc.2021.106491
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Development and validation of RP-HPLC method for quantification of repaglinide in mPEG-PCL polymeric nanoparticles: QbD-driven optimization, force degradation study, and assessment of in vitro release mathematic modeling

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Cited by 24 publications
(11 citation statements)
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“…A 1 mL aliquot of the release media was withdrawn at preset intervals and replenished with the same volume. Further, samples were filtered and analyzed by the RP-HPLC method . The drug release mechanism and kinetics were calculated by mathematical models using the DD solver (an Excel add-in).…”
Section: Methodsmentioning
confidence: 99%
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“…A 1 mL aliquot of the release media was withdrawn at preset intervals and replenished with the same volume. Further, samples were filtered and analyzed by the RP-HPLC method . The drug release mechanism and kinetics were calculated by mathematical models using the DD solver (an Excel add-in).…”
Section: Methodsmentioning
confidence: 99%
“…Lastly, rats were euthanized by intracardiac injection, and infused intestinal segments’ length ( L ) and diameter were carefully measured (Section S1, Supporting Information). , The quantitative detection of both the eluents, i.e. , phenol red and REP, was done by modifying the developed RP-HPLC method . The detector was set at maximum wavelengths of 243 and 398 nm for eluent data acquisition (REP and phenol red, respectively).…”
Section: Methodsmentioning
confidence: 99%
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“…(Vogt and Kord 2011;Peraman et al 2015b; Das and Maity 2017) As a result, using Quality by Design concepts towards the construction of analytical methods has become rather prevalent in order to achieve high robustness and superior method performance. (Monks et al 2012) In recent times, many analytical methods for single drug estimation (Alruwaili 2021;Jena et al 2021;Patel et al 2021;Srujani et al 2021;Wadhwa et al 2021) and simultaneous quantification (Gundala et al 2019;Saurabh Chaudhari et al 2022) have been developed using AQbD method. Analytical quality by design refers to the systematic and scientific creation and optimization of analytical procedures.…”
Section: Methods Development Incorporating Qbdmentioning
confidence: 99%