Development and Validation of Risk Matrices Concerning Ulcerative Colitis Outcomes—Bayesian Network Analysis

Long‐term follow‐up of patients treated with aminosalicylates for ulcerative colitis: Predictive factors of response: An observational case‐control study

“…An important point is the association of age and immunosuppressive therapy use, differing from the Swiss IBD cohort registry and the ACCESS Group observations 20 , 25 . In terms of surgery, extensive colitis, previous exposure to IMM, steroid refractoriness and disease diagnosis in the pre‐biologic era were shown to impact the likelihood of the patient requiring a colectomy; these results are in keeping with previously published articles 5 , 6 , 25–27 . Gender, smoking habits and hospitalization are known factors associated with colectomy risk 28 , 29 .…”

“…20,25 In terms of surgery, extensive colitis, previous exposure to IMM, steroid refractoriness and disease diagnosis in the prebiologic era were shown to impact the likelihood of the patient requiring a colectomy; these results are in keeping with previously published articles. 5,6,[25][26][27] Gender, smoking habits and hospitalization are known factors associated with colectomy risk. 28,29 In our study, these variables showed univariate association but were not retained as a significant influence in the multivariate analysis.…”

Long-term outcome of immunomodulator use in pediatric patients with inflammatory bowel disease

“…Several predictive variables for a poor disease course are suggested in adult literature, such as age younger than 40 years, extensive disease, smoking, use of corticosteroids and perianal disease or upper gastrointestinal tract involvement in Crohn's disease (CD) patients, [4][5][6][7][8][9][10][11]. However, based on these prognostic factors, all children could be considered as a high-risk group due to their age category.…”

Are there reliable predictive factors of nonresponse to aminosalicylates in patients with ulcerative colitis?

“…However, the role of combined treatment for the prevention of treatment escalation is unclear in the present study, even though as many as 48% of the patients were treated with this strategy. 6. It has been demonstrated that a substantial proportion of UC flares are attributable to aminosalicylates nonadherence.…”

“…[1][2][3][4][5] Recognizing patients at risk of medical therapy failure can appropriately optimize treatment escalation based on risk stratification. 6 Predictive factors of nonresponse to steroids-or even biologics-in the long term have been extensively studied. However, little is known about the long-term course of the disease judged by the need for treatment escalation among patients in remission with aminosalicylates.…”