Development and validation of nomogram based on SIRI for predicting the clinical outcome in patients with nasopharyngeal carcinomas

Abstract

The Systemic Inflammation Response Index (SIRI), based on peripheral lymphocyte, neutrophil, and monocyte counts, was recently investigated as a prognostic marker for several tumors. However, use of the SIRI has not been reported for nasopharyngeal carcinoma (NPC). We evaluated the prognostic value of the SIRI in primary and validation cohorts. We also established an effective prognostic nomogram for NPC based on clinicopathological parameters and the SIRI. The predictive accuracy and discriminative ability of the nomogram were determined using the concordance index (C-index) and a calibration curve and were compared with tumor-node-metastasis classifications. Our Kaplan-Meier survival analysis results showed that the SIRI was associated with the overall survival of patients with NPC in the primary and validation cohorts. The SIRI was identified to be an independent prognostic factor for NPC. In addition, we developed and validated a new prognostic nomogram that integrated clinicopathological factors and the SIRI. This nomogram can efficiently predict the prognosis of patients with NPC. The SIRI is a novel, simple and inexpensive prognostic predictor for patients with NPC. The SIRI has important value for predicting the prognosis of patients with NPC and developing individualized treatment plans.

Pretreatment peripheral blood leukocytes are independent predictors of survival in oral cavity cancer

“…A limited number of studies have been published analyzing the prognostic capacity of SIRI. [27][28][29][30][31] To the best of our knowledge, this is the first study analyzing SIRI as a prognostic factor in a large series of OSCC.…”

“…We agree with Qi et al that incorporating the prognostic value added by each leukocyte count creates an even more integrative biomarker than analyzing the individual counts. A limited number of studies have been published analyzing the prognostic capacity of SIRI . To the best of our knowledge, this is the first study analyzing SIRI as a prognostic factor in a large series of OSCC.…”

Prognostic capacity of Systemic Inflammation Response Index (SIRI) in patients with head and neck squamous cell carcinoma

“…In a cohort of 285 patients with nasopharyngeal carcinoma, Chen et al found a significant correlation between SIRI and OS. Using ROC curves, they were able to show how the AUC obtained with SIRI was superior to the AUC of other parameters such as NLR or LMR.…”

“…Later, Chen et al found that SIRI was significantly associated with overall survival (OS) in patients with nasopharyngeal carcinoma, acting as a biomarker with independent prognostic capacity. To the best of our knowledge, there are no studies analyzing the prognostic capacity of SIRI in patients with HNSCC in sites other than the nasopharynx.…”

Combining the Fibrinogen/Albumin Ratio and Systemic Inflammation Response Index Predicts Survival in Resectable Gastric Cancer

“…Over the past few decades, immune cell-related indices such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-tomonocyte ratio (LMR) have been used to predict prognosis and recurrence in various malignancies [2]. In recent years, a novel inflammatory marker, the systemic inflammation response index (SIRI), which is calculated using the levels of neutrophils, monocytes, and lymphocytes, has shown an ability to predict prognosis in pancreatic cancer [3], gastric cancer [4], and nasopharyngeal cancer [5].…”