Development and validation of MIX: comprehensive free software for meta-analysis of causal research data

Bax, Leon; Yu, Ly-Mee; Ikeda, Noriaki; Tsuruta, Harukazu; Moons, Karel G.M.

doi:10.1186/1471-2288-6-50

Cited by 465 publications

(301 citation statements)

References 20 publications

(12 reference statements)

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“…p \ 0.05 was considered representative of statistically significant publication bias [34,35]. All analyses were performed using the computer program MIX version 1.7 [36]. A p value less than 0.05 was considered statistically significant, and all the p values were two sided.…”

Section: Discussionmentioning

confidence: 99%

Methylenetetrahydrofolate Reductase C677T Polymorphism and Recurrent Pregnancy Loss Risk in Asian Population: A Meta-analysis

Rai

2016

Ind J Clin Biochem

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The C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene was implicated to be associated with thrombophilia due to its role in catalyzing the formation of 5-methylenetetrahydrofolate, a co-substrate for the conversion of homocysteine to methionine. Several case-control studies were investigated MTHFR C677T polymorphism as risk for recurrent pregnancy loss (RPL). These studies rendered contradictory results, some indicating that the polymorphism is associated with the risk of RPL whereas others concluded there is no association. To shed light on these inconclusive findings, a meta-analysis of all available studies published from Asian population relating the C677T polymorphism to the risk of RPL was conducted. The following electronic databases were searched without language restrictions: PubMed, Google Scholars, Elsevier and Springer Link up to December, 2015. Meta-analysis was performed using MetaAnalyst and Mix version 1.7. Meta-analysis results suggested that MTHFR C677T polymorphism contributed to the increased RPL risk in Asian population using all five genetic models (for T vs. C: OR 1.35, 95 % CI 1.09-1.68, p = 0.009; for TT ? CT vs. CC: OR 1.44, 95 % CI 1.14-1.82, p = 0.006; for CT vs. CC: OR 1.39, 95 % CI 1.07-1.8, p = 0.01; for TT vs. CC: OR 1.79, 95 % CI 1.23.2.6, p = 0.007; for TT vs. CT ? CC: OR 1.61, 95 % CI 1.02-2.56, p = 0.04). In conclusion, this meta-analysis demonstrates a strong association between the MTHFR C677T variant and RPL in Asian population and raising the importance of the use of folate in its treatment and prevention.

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Section: Discussionmentioning

confidence: 99%

Methylenetetrahydrofolate Reductase C677T Polymorphism and Recurrent Pregnancy Loss Risk in Asian Population: A Meta-analysis

Rai

2016

Ind J Clin Biochem

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“…The meta-analyses were carried out using the program Meta-analysis with Interactive eXplanations (MIX, version 1.54) (Bax et al, 2006). To detect potential effects of different ancestries (European versus Asian) or study design types (case-control versus family-based), overall ORs and SEs were obtained for each group, then heterogeneity of overall ORs between different ancestries or study designs were assessed using a chi-square test with one degree of freedom, similar to the method introduced by Kazeem and Farrall (Kazeem and Farrall, 2005).…”

Section: Statistical Analysesmentioning

confidence: 99%

Allelic association of G72/G30 with schizophrenia and bipolar disorder: A comprehensive meta-analysis

Shi

Badner

Gershon

et al. 2008

Schizophrenia Research

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The G72/G30 gene complex (G72 also known as D-amino acid oxidase activator, DAOA) and its chromosomal region 13q32-34 have been linked and associated with both schizophrenia (SCZ) and bipolar disorder (BP) in multiple studies, including our initial association report on BP. However, the inconsistency of associated variants across studies is obvious. Previous meta-analyses had small data sets. The present meta-analysis combined 18 association articles published before April of 2007. There were 19 independent studies of SCZ, with 4304 cases, 5423 controls, and 1384 families, and four independent studies of BP with 1145 cases, 1829 controls, and 174 families. Of 15 single nucleotide polymorphisms (SNPs) analyzed in the 95-kb G72/G30 gene region, M18/rs947267 and M22/rs778293 showed association with SCZ in Asians, and M24/rs1421292 with SCZ in Europeans. The associations of C allele at M18 and A allele at M22 with SCZ in Asians survived conservative Bonferroni correction for multiple testing for 15 markers and subgroup analysis (adjusted P = 0.0000253 for M18; adjusted P = 0.009 for M22). No single maker showed evidence of overall association with BP. These results suggest that G72/G30 may influence susceptibility to schizophrenia with weak effects.

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“…Random errors were added to the estimates, so that within-and between-study variances could be adjusted and weighted. 6 Tests of heterogeneity among studies were also performed with the chi-square test, and the extent of the heterogeneity was assessed with the I 2 statistic 39 at the outcome level. To assess for publication bias, a funnel plot was generated, in which asymmetry of the plot was interpreted to suggest that positive studies with larger samples tend to be published more readily than studies with smaller samples and/or negative (lack of statistical significance) results.…”

Section: Data Synthesis and Analysismentioning

confidence: 99%

Association Between Foot Type and Lower Extremity Injuries: Systematic Literature Review With Meta-analysis

Tong

Kong²

2013

J Orthop Sports Phys Ther

125

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T he human foot is often classified into 3 structural categories: high, normal, and low arch, based on its anatomical alignment 89 and the height of the medial longitudinal arch. 27 Classification in these 3 categories is typically based on cutoff values determined from the distribution of data (standard deviations 65,93,102 or percentiles 15,16 ) from measurements taken on a large population. The interest in such classification is the belief that nonneutral foot morphology, such as a high or low arch (flatfoot), may lead to less than optimal foot function and be associated with the development of lower extremity and low back injuries. 23,28,29,59 A review of the literature provides conflicting evidence on the potential relationship between foot type and lower extremity injuries. Although a number of published reports have found no relationships between nonneutral foot types and lower extremity injuries, 40,94,96,99 the authors of a recent systematic review concluded that both high-and low-arch foot types were associated with runningrelated injuries. 14 The results of this systematic review, 14 which did not include a meta-analysis and effect-size estimates, contrast those of a few qualitative reviews that failed to demonstrate a relationship between foot type and future lower extremity injuries. 4,8,20,70 This lack of consensus in the literature could be attributed, in part, to the variation in the operational definition of foot type among investigators. 4,70 A large variety of methods have been developed to classify the foot based on structure and alignment. These T T OBJECTIVES:To investigate the association between nonneutral foot types (high arch and flatfoot) and lower extremity and low back injuries, and to identify the most appropriate methods to use for foot classification. T T METHODS:A search of 5 electronic databases (PubMed, Embase, CINAHL, SPORTDiscus, and ProQuest Dissertations and Theses), Google Scholar, and the reference lists of included studies was conducted to identify relevant articles. The review included comparative cross-sectional, casecontrol, and prospective studies that reported qualitative/quantitative associations between foot types and lower extremity and back injuries. Quality of the selected studies was evaluated, and data synthesis for the level of association between foot types and injuries was conducted. A randomeffects model was used to pool odds ratio (OR) and standardized mean difference (SMD) results for meta-analysis. T T RESULTS:Twenty-nine studies were included for meta-analysis. A significant association between nonneutral foot types and lower extremity injuries was determined (OR = 1.23; 95% confidence interval [CI]: 1.11, 1.37; P<.001). Foot posture index (OR = 2.58; 95% CI: 1.33, 5.02; P<.01) and visual/ physical examination (OR = 1.17; 95% CI: 1.06, 1.28; P<.01) were 2 assessment methods using distinct foot-type categories that showed a significant association with lower extremity injuries.

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Development and validation of MIX: comprehensive free software for meta-analysis of causal research data

Cited by 465 publications

References 20 publications

Methylenetetrahydrofolate Reductase C677T Polymorphism and Recurrent Pregnancy Loss Risk in Asian Population: A Meta-analysis

Methylenetetrahydrofolate Reductase C677T Polymorphism and Recurrent Pregnancy Loss Risk in Asian Population: A Meta-analysis

Allelic association of G72/G30 with schizophrenia and bipolar disorder: A comprehensive meta-analysis

Association Between Foot Type and Lower Extremity Injuries: Systematic Literature Review With Meta-analysis

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