Development and validation of liquid chromatography–tandem mass spectrometry method for simultaneous determination of zinc pyrithione and pyrithione in shampoos

Abstract

A simple, rapid, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of zinc pyrithione (ZnPT) and pyrithione (PT) in shampoos. The method consisted of a liquid-liquid extraction for sample preparation. The mass spectrometer was operated in multiple reaction monitoring (MRM) mode via the positive electrospray ionization interface. A linear regression (weighted 1/x) was used to fit calibration curves over the concentration range of 50-2000 ng/mL for both ZnPT and PT. Excellent linearity (r 2 ≥ 0.9996) was achieved for all. The method was validated and found to be accurate (95.9-108.2% for ZnPT and 94.9-110.4% for PT), precise, and selective. Analytes in shampoos were found to be stable in the autosampler (6°C for 6 h), in room temperature (for 6 h), and after three freeze-thaw cycles, and recovery of analytes was reproducible (90.8-94.6% for ZnPT and 90.2-96.3% for PT).

Combined effects of antifouling biocides on the growth of three marine microalgal species

“…In addition to the interaction between Cu and ZnPT, EDTA, which is part of the f/2 culture medium in the form of Na 2 EDTA, was also shown to interact with ZnPT, by chelating zinc from ZnPT, thus dissociating ZnPT into NaPT (Kim et al, 2017). As NaPT form was not measured in the chemical analyses performed, there is no evidence indicating the formation of this substance in our experiments.…”

Determination of Free Histidine in Complex Hair Care Products with Minimum Sample Preparation Using Cation-Exchange Chromatography and Post Column Derivatization

“…From an analytical chemistry point of view, hair care products are considered to be complicated matrices containing numerous organic and inorganic compounds, thus requiring extra sample cleanup steps prior to the end-point analysis. Representative recent analytical applications in hair care products are presented in Table 1 [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. As can be seen in the examples of Table 1 , solid- or liquid-phase extraction steps are quite common even when sophisticated LC-MS instrumentation is employed, while dry ashing/wet digestion are necessary for the determination of inorganic analytes.…”

Evaluation of the phenyl-bonded silica-based sorbent for pre-concentration of the booster antifouling biocides Zinc Pyrithione, Zineb and Ziram using solid-phase extraction technique and Inductively Coupled Plasma Mass Spectrometry

“…So, a new generation of booster antifouling biocides has been used: chlorothalonil, dichlofluanid, Irgarol 1051, TCMS pyridine, Eclética Química Journal, vol. 45, n. 4, 2020, [21][22][23][24][25][26][27][28][29][30][31] ISSN: 1678-4618 DOI: 10.26850/1678-4618eqj.v45. 4.2020.p21-31 thiocyanatomethylthio-benzothiazole (TCMTB), diuron, dichloro-octylisothiazolin (DCOIT, Sea Nine 211), zinc and copper pyrithione (zinc and copper omadine), Zineb (zinc ethylenebisdithiocarbamate) and Ziram (zinc dimethyldithiocarbamate) [2][3][4] .…”

“…Different hyphenated instrumental methods have been used to determinate the booster antifouling biocides over the years, e.g. HPLC coupled with: i) Ultraviolet-Visible (UV-VIS) 10,12,17,20,[23][24][25][26] , ii) Diode-Array (DAD) 12 , iii) Electrospray Ionization Mass Spectrometry (ESI-MS) 12 , iv) Atmospheric Pressure Chemical Ionization Mass Spectrometry (APCI-MS) 18,25 , v) Tandem-Mass Spectrometry (MS/MS) 26,27 , vi) Atomic Absorption Spectrometry 28 , vii) fluorescence 29 .…”