Development and Validation of FT-IR Spectrophotometric Method for Simultaneous Estimation of Clonidine Hydrochloride and Chlorthalidone in Pharmaceutical Synthetic Mixture
T. M. Kalyankar,
S. J. Wadher,
Shital Gaikwad
et al.
Abstract:A precise, simple, cost effective, accurate, eco-friendly and validated fourier transform infrared spectroscopy method has been developed for the simultaneous estimation of Clonidine Hydrochloride and Chlorthalidone in pharmaceutical synthetic mixture. The developed method involves measurement of spectral wavenumber of the infrared band corresponding to (–C=N) from 1658.78 cm-1 for Clonidine Hydrochloride and (-S=O) group from 1346.31 cm-1 for Chlorthalidone. Over the range of 1.5–3% w/w for Clonidine hydrochl… Show more
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