Development and validation of different chemometric-assisted spectrophotometric methods for determination of cefoxitin-sodium in presence of its alkali-induced degradation product

Attia, Khalid A.M.; Abdelaziz, Omar Y.; Magdy, Nancy; Mohamed, Gamal A.

doi:10.1016/j.fjps.2018.08.002

Cited by 6 publications

(10 citation statements)

References 26 publications

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“…Attia et al [123] also developed spectrometric methods for determination of cefoxitin-sodium in the presence of its alkaline degradation product using different chemometric tools. PLS was applied to quantify cefoxitin-sodium in pharmaceutical sample.…”

Section: Applications Of Chemometric Tools In Forced Degradation Smentioning

confidence: 99%

“…PLS was applied to quantify cefoxitin-sodium in pharmaceutical sample. To obtain degradation product, the basic forced degradation was performed using NaOH 0.1 M for 10 min, which was neutralized with HCl 0.1 M. More details about the procedure to prepare the working solution are in reference [123]. The PLS model was built considering 13 mixtures denominated calibration set and 12 mixtures as a validation set obtained through experimental design.…”

Section: Applications Of Chemometric Tools In Forced Degradation Smentioning

confidence: 99%

“…To the best of our knowledge, two works regarding to forced degradation studies and artificial neural network are reported in the literature, and only one of them uses ANNs as the main tool [123,154].…”

Section: Applications Of Chemometric Tools In Forced Degradation Smentioning

confidence: 99%

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Chemometrics Approaches in Forced Degradation Studies of Pharmaceutical Drugs

Alvarenga

Carneiro

2019

Molecules

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Chemometrics is the chemistry field responsible for planning and extracting the maximum of information of experiments from chemical data using mathematical tools (linear algebra, statistics, and so on). Active pharmaceutical ingredients (APIs) can form impurities when exposed to excipients or environmental variables such as light, high temperatures, acidic or basic conditions, humidity, and oxidative environment. By considering that these impurities can affect the safety and efficacy of the drug product, it is necessary to know how these impurities are yielded and to establish the pathway of their formation. In this context, forced degradation studies of pharmaceutical drugs have been used for the characterization of physicochemical stability of APIs. These studies are also essential in the validation of analytical methodologies, in order to prove the selectivity of methods for the API and its impurities and to create strategies to avoid the formation of degradation products. This review aims to demonstrate how forced degradation studies have been actually performed and the applications of chemometric tools in related studies. Some papers are going to be discussed to exemplify the chemometric applications in forced degradation studies.

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Section: Applications Of Chemometric Tools In Forced Degradation Smentioning

confidence: 99%

Section: Applications Of Chemometric Tools In Forced Degradation Smentioning

confidence: 99%

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Chemometrics Approaches in Forced Degradation Studies of Pharmaceutical Drugs

Alvarenga

Carneiro

2019

Molecules

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“…The official procedures in pharmaceutical preparations utilize iodometric titration, [3,4] spectrophotometric, spectrofluorometric. [5][6][7] and HPLC methods. [8] High-performance liquid chromatographic procedures were used to quantify the cefoxitin content of biological fluids.…”

Section: Introductionmentioning

confidence: 99%

“…Several methods have been reported for cefoxitin determination. The official procedures in pharmaceutical preparations utilize iodometric titration, [3,4] spectrophotometric, spectrofluorometric [5–7] . and HPLC methods [8] .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Reduction and Oxidation of the Antibiotic Cefoxitin‐Cu²⁺ Complex and its Analytical Applications

et al. 2021

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The interaction of cefoxitin, being a compound of interest for antibiotic research, with Cu 2 + resulted in the formation of a 1 : 1 complex. The electrochemical reduction at a hanging mercury drop electrode and oxidation at a renewable pencil graphite electrode of the formed cefoxitin-Cu 2 + complex was investigated using cyclic voltammetry and differential pulse voltammetry in Britton-Robinson buffers (pH 2-9). For the electrochemical reduction or oxidation of the examined complex, a new well-defined voltammetric peak was obtained and the features of the surface redox and oxidation peaks were studied. Calculations of the values of stability constant and the change on Gibbs free energy for cefoxitin-Cu 2 + complex suggest that the complexation is a spontaneous process. The sharp peak of the electroreduction and oxidation of the investigated complex associated with an effective interfacial accumulation of this complex facilitates the determination of the antibacterial drug cefoxitin in the bulk and blood serum samples. Cefoxitin was determined by electrochemical reduction and oxidation of the cefoxitin-Cu 2 + complex, with detection limits of 6.94 × 10 À 9 M and 9.07 × 10 À 8 M respectively.

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Utilization of a complex arrangement approach for spectroscopic examination with Eosin Y of various cephalosporins in their pure or pharmaceutical dosage forms, and in human plasma

et al. 2021

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Approved, basic, effective and successful spectroscopic strategies (spectrophotometric and spectrofluorimetric) were created to measure seven cephalosporins: cefpiramide (I), cefuroxime (II), cefoxitin (III), ceftazidime (IV), cefpirome (V), ceftobiprole (VI), and ceftriaxone (VII). These strategies used a two-fold complex arrangement response for the drug amino groups with Eosin Y (EY). The examined drugs were determined spectrophotometrically at 542-550 nm in acetic acid derivative buffer. The examined drugs were determined spectrofluorimetrically by measuring their quenching effect on EY local fluorescence at 545 nm after excitation at 305 nm. The absorbance-intensity

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Development and validation of different chemometric-assisted spectrophotometric methods for determination of cefoxitin-sodium in presence of its alkali-induced degradation product

Cited by 6 publications

References 26 publications

Chemometrics Approaches in Forced Degradation Studies of Pharmaceutical Drugs

Chemometrics Approaches in Forced Degradation Studies of Pharmaceutical Drugs

Electrochemical Reduction and Oxidation of the Antibiotic Cefoxitin‐Cu²⁺ Complex and its Analytical Applications

Utilization of a complex arrangement approach for spectroscopic examination with Eosin Y of various cephalosporins in their pure or pharmaceutical dosage forms, and in human plasma

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Development and validation of different chemometric-assisted spectrophotometric methods for determination of cefoxitin-sodium in presence of its alkali-induced degradation product

Cited by 6 publications

References 26 publications

Chemometrics Approaches in Forced Degradation Studies of Pharmaceutical Drugs

Chemometrics Approaches in Forced Degradation Studies of Pharmaceutical Drugs

Electrochemical Reduction and Oxidation of the Antibiotic Cefoxitin‐Cu2+ Complex and its Analytical Applications

Utilization of a complex arrangement approach for spectroscopic examination with Eosin Y of various cephalosporins in their pure or pharmaceutical dosage forms, and in human plasma

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Product

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Electrochemical Reduction and Oxidation of the Antibiotic Cefoxitin‐Cu²⁺ Complex and its Analytical Applications