Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry

Zacca, Jorge Jardim; Giudice, Gabriella H.; Souza, Mônica P.; Caldas, Luíza N.B.; Vieira, Maurício L.; Machado, Angelo H. L.

doi:10.1016/j.chroma.2020.461783

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…A series of n -alkanes (C 7 –C 30 ) were analyzed by GC-MS under the same conditions as mentioned in Section 2.4 . The identified compounds were then reconfirmed by calculating the linear retention index with standards [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Characteristic Volatiles and Cultivar Classification in 35 Apple Varieties: A Case Study of Two Harvest Years

Fauconnier

2022

Foods

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A large number of apple varieties (35) from the same germplasm were investigated over two consecutive harvest years. A total of 39 volatile compounds were identified by HS-SPME-GC-MS, and quantified by external standards. Principal component analysis was applied to study the relationship between varieties and volatiles. To obtain better discrimination, 23 of 35 apple varieties were classified into four cultivars and good classification could be observed by partial least squares discriminant analysis. Ethyl 2-methylbutyrate, 2-methyl-1-butanol, Z-3-hexenyl acetate, E-2-hexen-1-ol, linalool and dodecanol were the most important variables to discriminate apple cultivars. Based on the volatile concentration and thresholds, ethyl 2-methylbutyrate, hexanal, 1-hexanol, E-2-nonenal and linalool were the critical characterized odor-active compounds among 35 apple varieties over two harvest years. From the present work, seasonal effects greatly influenced the formation of volatiles.

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Section: Methodsmentioning

confidence: 99%

Characteristic Volatiles and Cultivar Classification in 35 Apple Varieties: A Case Study of Two Harvest Years

Fauconnier

2022

Foods

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“…The analysis can also be performed by comparison of the analytical findings within a sample to comprehensive instrumental libraries, such as SWGDRUG and NIST (Kelly & Bell, 2018). If a certified reference material is unavailable in‐house, there are some alternative chromatographic strategies that can be used such as retention time locking, relative retention time or retention index for comparison with data from a partnering laboratory (UNODC, 2020; Zacca et al, 2021). Recently, a GC‐MS method based on linear retention indexes was developed and validated for 22 drugs, including the synthetic cathinones N ‐ethylpentylone, resulting in a selective method with potential to be implemented in routine testing (Zacca et al, 2021).…”

Section: Gas Chromatography–mass Spectrometrymentioning

confidence: 99%

Identification of synthetic cathinones in seized materials: A review of analytical strategies applied in forensic chemistry

Campos

Krotulski

Martinis

et al. 2022

WIREs Forensic Science

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Synthetic cathinones are a class of novel psychoactive substances, commonly tested in seized materials by forensic chemistry laboratories. These drugs have been found in different types of seized materials including powders, tablets, liquids, herbs, and blotters. A comprehensive review of the literature shows that the analyses of synthetic cathinones have been performed by a diverse repertoire of techniques, from more traditional to emerging methods. Techniques commonly used in the analysis of "traditional" illicit drugs, such as color and microcrystalline tests, chromatography, capillary electrophoresis, mass spectrometry (MS), and infrared (IR), and Raman spectroscopies, have been used for screening and/or confirmatory purposes, depending on the technique and laboratories preference. However, other emerging techniques, such as nuclear magnetic resonance, high-resolution MS, direct analysis in real-time MS, gas chromatography with IR detection, and so on, have been drawing the attention of forensic scientists due to the advantages of these techniques in providing important structural data. It is important to consider that each technique presents analytical benefits and limitations, which should be considered when analyzing synthetic cathinones in seized materials. Furthermore, the combination of more than one analytical technique is always recommended, especially when an unknown synthetic cathinone is suspected and/or encountered in the sample.

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“…Synthetic cannabinoids (SCs) are an important class of NPSs. 8,9 SCs are a series of synthetic substances that have similar pharmacological properties to those of natural cannabinoids. 10,11 SCs bind to the corresponding CB1 and CB2 receptors.…”

Section: Introductionmentioning

confidence: 99%

Sensitive detection of synthetic cannabinoids in human blood using magnetic polydopamine molecularly imprinted polymer nanocomposites

Li¹,

Wang²,

Liu³

et al. 2023

Analyst

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Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry

Cited by 10 publications

References 22 publications

Characteristic Volatiles and Cultivar Classification in 35 Apple Varieties: A Case Study of Two Harvest Years

Characteristic Volatiles and Cultivar Classification in 35 Apple Varieties: A Case Study of Two Harvest Years

Identification of synthetic cathinones in seized materials: A review of analytical strategies applied in forensic chemistry

Sensitive detection of synthetic cannabinoids in human blood using magnetic polydopamine molecularly imprinted polymer nanocomposites

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