Development and validation of an ultra high performance liquid chromatography-tandem mass spectrometry method for the determination of phthalate esters in Greek grape marc spirits

Diamantidou, Dimitra; Begou, Olga; Theodoridis, Georgios; Gika, Helen; Tsochatzis, Emmanouil D.; Kalogiannis, Stavros; Kataiftsi, Natalia; Soufleros, Evangelos H.; Zotou, Anastasia

doi:10.1016/j.chroma.2019.06.034

Cited by 25 publications

(19 citation statements)

References 28 publications

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“…In addition, Perestrelo et al [ 60 ] used the SPME extraction procedure to analyze food-contacted plastics in which the amounts detected ranged from 1.0 to 2.8 µg/L for BBP and DOP, respectively. Diamantidou and collaborators [ 84 ] determined the levels of PAEs in 45 samples from Greek grape marc spirits using the ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method. The amounts in samples ranged from 1.25 to 113,220 µg/L for dipentyl phthalate (DPeP) and DEHP, respectively.…”

Section: Occurrence Of Phthalatesmentioning

confidence: 99%

“…Recently, ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) compared to LC-MS/MS have the potentiality to separate the PAEs in a shorter run time (14 to 16 min) and use smaller particle LC columns (2.1 µm), which allows obtaining narrower peaks and high sample throughput [ 73 , 84 , 101 , 108 ]. Electrospray ionization (ESI) interface, triple quadrupole (QqQ), and/or quadrupole time of flight (TOF) mass analyzer and MRM modes are the most common combination used in LC-MS for quantification of PAEs [ 73 , 84 , 101 , 108 ]. Diamantidou et al [ 84 ] have proposed a direct UPLC-MS/MS for analysis of 12 PAEs in grape marc spirits of Greek origin.…”

Section: Analytical Approachesmentioning

confidence: 99%

“…Electrospray ionization (ESI) interface, triple quadrupole (QqQ), and/or quadrupole time of flight (TOF) mass analyzer and MRM modes are the most common combination used in LC-MS for quantification of PAEs [ 73 , 84 , 101 , 108 ]. Diamantidou et al [ 84 ] have proposed a direct UPLC-MS/MS for analysis of 12 PAEs in grape marc spirits of Greek origin. The PAEs were separated using a U-VDSpher PUR 100 C18-E (100 mm × 2.0 mm, 1.8 μm) column by gradient elution.…”

Section: Analytical Approachesmentioning

confidence: 99%

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Comprehensive Insight from Phthalates Occurrence: From Health Outcomes to Emerging Analytical Approaches

Luís

Algarra

Câmara

2021

Toxics

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Phthalates are a group of chemicals used in a multitude of important industrial products (e.g., medical devices, children’s toys, and food packages), mainly as plasticizers to improve mechanical properties such as flexibility, transparency, durability, and longevity of polyvinyl chloride (PVC). The wide occurrence of phthalates in many consumer products, including foods (e.g., bottled water, soft drinks, wine, milk, and meat) brings that most people are exposed to phthalates every day, which raises some concerns. Adverse health outcomes from phthalates exposure have been associated with endocrine disruption, deformities in the human reproductive system, increased risk of preterm birth, carcinogen exposure, among others. Apprehension related to the health risks and ubiquitous incidence of phthalates in foods inspires the development of reliable analytical approaches that allow their detection and quantification at trace levels. The purpose of the current review is to provide information related to the presence of phthalates in the food chain, highlighting the health risks associated with their exposure. Moreover, an overview of emerging extraction procedures and high-resolution analytical approaches for a comprehensive quantification of phthalates is presented.

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Section: Occurrence Of Phthalatesmentioning

confidence: 99%

Section: Analytical Approachesmentioning

confidence: 99%

Section: Analytical Approachesmentioning

confidence: 99%

See 1 more Smart Citation

Comprehensive Insight from Phthalates Occurrence: From Health Outcomes to Emerging Analytical Approaches

Luís

Algarra

Câmara

2021

Toxics

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“…Regulated substances and non-intentionally added substances (NIAS) migrating into food or official food simulants have been studied by different analytical approaches covering BPA, phthalates [150] and other NIAS [151].…”

Section: Assessment Of Food Safetymentioning

confidence: 99%

FoodOmicsGR_RI: A Consortium for Comprehensive Molecular Characterisation of Food Products

et al. 2021

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The national infrastructure FoodOmicsGR_RI coordinates research efforts from eight Greek Universities and Research Centers in a network aiming to support research and development (R&D) in the agri-food sector. The goals of FoodOmicsGR_RI are the comprehensive in-depth characterization of foods using cutting-edge omics technologies and the support of dietary/nutrition studies. The network combines strong omics expertise with expert field/application scientists (food/nutrition sciences, plant protection/plant growth, animal husbandry, apiculture and 10 other fields). Human resources involve more than 60 staff scientists and more than 30 recruits. State-of-the-art technologies and instrumentation is available for the comprehensive mapping of the food composition and available genetic resources, the assessment of the distinct value of foods, and the effect of nutritional intervention on the metabolic profile of biological samples of consumers and animal models. The consortium has the know-how and expertise that covers the breadth of the Greek agri-food sector. Metabolomics teams have developed and implemented a variety of methods for profiling and quantitative analysis. The implementation plan includes the following research axes: development of a detailed database of Greek food constituents; exploitation of “omics” technologies to assess domestic agricultural biodiversity aiding authenticity-traceability control/certification of geographical/genetic origin; highlighting unique characteristics of Greek products with an emphasis on quality, sustainability and food safety; assessment of diet’s effect on health and well-being; creating added value from agri-food waste. FoodOmicsGR_RI develops new tools to evaluate the nutritional value of Greek foods, study the role of traditional foods and Greek functional foods in the prevention of chronic diseases and support health claims of Greek traditional products. FoodOmicsGR_RI provides access to state-of-the-art facilities, unique, well-characterised sample sets, obtained from precision/experimental farming/breeding (milk, honey, meat, olive oil and so forth) along with more than 20 complementary scientific disciplines. FoodOmicsGR_RI is open for collaboration with national and international stakeholders.

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“…From our previous work, we found that chromatography techniques are the preferred methods of determining PAEs due to their accurate and stable results [1]. However, if these methods are employed to determine PAE contamination, GC/HPLC with UV/MS exhibits some disadvantages: tedious procedures, requiring large amounts of hazardous organic solvents, expensive to perform in a special laboratory, and necessitating professional operators [17]. Additionally, these instruments cannot be easily transported and run on site.…”

Section: Introductionmentioning

confidence: 99%

Facile and Selective Determination of Total Phthalic Acid Esters Level in Soft Drinks by Molecular Fluorescence Based on Petroleum Ether Microextraction and Selective Derivation by H2SO4

et al. 2022

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Determining the level of phthalic acid esters (PAEs) in packaged carbonated beverages is a current need to ensure food safety. High-selectivity and -accuracy identification of individual PAEs can be achieved by chromatographic and mass spectrometric (MS) techniques. However, these methods are slow; involve complicated, expensive instruments in professional laboratories; and consume a large amount of organic solvents. As such, a food analysis method is needed to conveniently and rapidly evaluate multiple contaminants on site. In this study, with the assistance of ultrasound, we quickly determined the total PAEs in soft drinks using 1.5 mL of petroleum ether in one step. Then, we determined the characteristic molecular fluorescence spectrum of all PAEs in samples (excitation (Ex)/emission (Em) at 218/351 nm) using selectively concentrated sulfuric acid derivatization. The relative standard deviations of the fluorescent intensities of mixed solutions with five different PAEs were lower than 7.1% at three concentration levels. The limit of detection of the proposed method is 0.10 μmol L−1, which matches that of some of the chromatographic methods, but the proposed method uses less organic solvent and cheaper instruments. These microextraction devices and the fluorescence spectrometer are portable and provide an instant result, which shows promise for the evaluation of the total level of PAEs in beverages on site. The proposed method successfully detected the total level of PAEs in 38 kinds of soft drink samples from local supermarkets, indicating its potential for applications in the packaged beverage industry.

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Development and validation of an ultra high performance liquid chromatography-tandem mass spectrometry method for the determination of phthalate esters in Greek grape marc spirits

Cited by 25 publications

References 28 publications

Comprehensive Insight from Phthalates Occurrence: From Health Outcomes to Emerging Analytical Approaches

Comprehensive Insight from Phthalates Occurrence: From Health Outcomes to Emerging Analytical Approaches

FoodOmicsGR_RI: A Consortium for Comprehensive Molecular Characterisation of Food Products

Facile and Selective Determination of Total Phthalic Acid Esters Level in Soft Drinks by Molecular Fluorescence Based on Petroleum Ether Microextraction and Selective Derivation by H2SO4

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