Development and validation of an LC–MS/MS method to measure the BRAF inhibitors dabrafenib and encorafenib quantitatively and four major metabolites semi-quantitatively in human plasma

Electrochemical Determination of Anti‐Cancer Drug Dabrafenib with High Sensitivity Using Multi‐Walled Carbon Nano Tubes Modified Glassy Carbon Electrode

“…Its approval by the US Food and Drug Administration (US‐FDA) in 2013 marked a significant advancement in cancer therapy. The rising utilization of targeted anticancer drugs, such as DAB, is notable, particularly among patients facing advanced cancer stages or pediatric cases that have become refractory to conventional treatment modalities [1–6] . It has been reported that Dabrafenib provides positive outcomes in patients treated by inhibiting the growth and spread of cancer cells.…”

“…[7] In the literature survey, numerous analytical methods have been developed for the quantitative analysis of Dabrafenib (DAB), including high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), fluorescence technique, and electrophoresis. [8][9][10][11][12][13][14][15][16][17][18][19][20] While these methods are effective and sensitive in detecting and quantifying DAB, they are often associated with drawbacks such as high costs and environmental concerns arising from the extensive use of organic solvents. Additionally, these methods may require lengthy analysis times and the expertise of trained professionals to operate analytical instruments effectively.…”

“…The rising utilization of targeted anticancer drugs, such as DAB, is notable, particularly among patients facing advanced cancer stages or pediatric cases that have become refractory to conventional treatment modalities. [1][2][3][4][5][6] It has been reported that Dabrafenib provides positive outcomes in patients treated by inhibiting the growth and spread of cancer cells. Therefore, monitoring Dabrafenib is important because ensuring accurate dosages and monitoring side effects can impact patients' health status and determine the success of treatment.…”