Development and validation of an ICP-MS method for quantification of total carbon and platinum in cell samples and comparison of open-vessel and microwave-assisted acid digestion methods

Riisom, Mie; Gammelgaard, Bente; Lambert, Ian Henry; Stürup, Stefan

doi:10.1016/j.jpba.2018.05.038

Cited by 26 publications

(7 citation statements)

References 27 publications

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“…Closed vessel digestion was chosen to minimize the loss of volatile trace elemental impurities and to reduce the residual carbon content [ 14 , 27 ]. Prior to the final digestion procedure (see section 2.3 .…”

Section: Resultsmentioning

confidence: 99%

Determination of trace elements in ibuprofen drug products using microwave-assisted acid digestion and inductively coupled plasma-mass spectrometry

Holmfred,

Alrijjal,

Chamberlain

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Determination of trace elements in ibuprofen drug products using microwave-assisted acid digestion and inductively coupled plasma-mass spectrometry

Holmfred,

Alrijjal,

Chamberlain

et al. 2024

Heliyon

Self Cite

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“…Meanwhile, the residue in the black cracks is likely to be organic matter such as carbon as the concentration levels of elements of the residue are much lower than the values of the elements in the brown cracks. The ICP-MS cannot efficiently ionize the carbon (Riisom et al, 2018). Theoretically, only 1% carbon can be ionized by the ICP, resulting in the sensitivity for the carbon determinations is much lower than metals, metalloids, and rare-earth elements (REEs) (Luong & Houk, 2003).…”

Section: Resultsmentioning

confidence: 99%

Insights into the Residue Trapped in Glaze Cracks of Archaeological Ceramics Using Microchemical Analysis

Yuan

Cao

et al. 2022

Microscopy and Microanalysis

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Searching for residue in the glaze of porcelain or stoneware is a difficult task because these glazes are high-fired, well vitrified, and nonporous. This paper analyzes the chemical composition of residue observed in glaze cracks of porcelain via SEM-EDS to determine how the crackle effect was produced, in particular, if it was intentionally created during production or the result of post-depositional processes. This study offers insights to a specific type of ancient Chinese porcelain called “Ge-type ware”, which has two different types of cracks, and whose origin has been debated for nearly 60 years because it has never been found at any kiln site. This paper analyzes the chemical composition of the two crack types, first using elemental mapping to ascertain the different mechanisms that produced these two crack types of the Heirloom Ge ware, and second using residue analysis and chemical fingerprinting to determine the provenance of this puzzling type of porcelain. In doing so, this paper demonstrates how the residue in the glaze of porcelain can be observed and analyzed via microchemical approaches and hopes to inspire more research using this technique in future.

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“…In order to decompose the organic matrix, samples were processed in 100 μL 65% HNO 3 and 100 μL H 2 O 2 at 80 °C for nitrification, then cooled to room temperature. Then, all samples were diluted in 2% HNO 3 to a final volume of 5 mL and eventually quantification of intracellular elements by ICP-MS. To validate the method, we evaluated the linearity, limit of detection (LOD), and the limit of quantification (LOQ) [ 51 ]. When cell samples were assessed by ICP-MS, a blank and a trace elements serum L-2 RUO were measured for each time as quality control.…”

Section: Methodsmentioning

confidence: 99%

The Impact of ZIP8 Disease-Associated Variants G38R, C113S, G204C, and S335T on Selenium and Cadmium Accumulations: The First Characterization

Liang

Tan

et al. 2021

IJMS

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The metal cation symporter ZIP8 (SLC39A8) is a transmembrane protein that imports the essential micronutrients iron, manganese, and zinc, as well as heavy toxic metal cadmium (Cd). It has been recently suggested that selenium (Se), another essential micronutrient that has long been known for its role in human health and cancer risk, may also be transported by the ZIP8 protein. Several mutations in the ZIP8 gene are associated with the aberrant ion homeostasis of cells and can lead to human diseases. However, the intricate relationships between ZIP8 mutations, cellular Se homeostasis, and human diseases (including cancers and illnesses associated with Cd exposure) have not been explored. To further verify if ZIP8 is involved in cellular Se transportation, we first knockout (KO) the endogenous expression of ZIP8 in the HeLa cells using the CRISPR/Cas9 system. The elimination of ZIP8 expression was examined by PCR, DNA sequencing, immunoblot, and immunofluorescence analyses. Inductively coupled plasma mass spectrometry indicated that reduced uptake of Se, along with other micronutrients and Cd, was observed in the ZIP8-KO cells. In contrast, when ZIP8 was overexpressed, increased Se uptake could be detected in the ZIP8-overexpressing cells. Additionally, we found that ZIP8 with disease-associated single-point mutations G38R, G204C, and S335T, but not C113S, showed reduced Se transport ability. We then evaluated the potential of Se on Cd cytotoxicity prevention and therapy of cancers. Results indicated that Se could suppress Cd-induced cytotoxicity via decreasing the intracellular Cd transported by ZIP8, and Se exhibited excellent anticancer activity against not all but only selected cancer cell lines, under restricted experimental conditions. Moreover, clinical-based bioinformatic analyses revealed that up-regulated ZIP8 gene expression was common across multiple cancer types, and selenoproteins that were significantly co-expressed with ZIP8 in these cancers had been identified. Taken together, this study concludes that ZIP8 is an important protein in modulating cellular Se levels and provides insights into the roles of ZIP8 and Se in disease prevention and therapy.

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Development and validation of an ICP-MS method for quantification of total carbon and platinum in cell samples and comparison of open-vessel and microwave-assisted acid digestion methods

Cited by 26 publications

References 27 publications

Determination of trace elements in ibuprofen drug products using microwave-assisted acid digestion and inductively coupled plasma-mass spectrometry

Determination of trace elements in ibuprofen drug products using microwave-assisted acid digestion and inductively coupled plasma-mass spectrometry

Insights into the Residue Trapped in Glaze Cracks of Archaeological Ceramics Using Microchemical Analysis

The Impact of ZIP8 Disease-Associated Variants G38R, C113S, G204C, and S335T on Selenium and Cadmium Accumulations: The First Characterization

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