Development and Validation of an Electronic Medical Record–Based Algorithm to Identify Patient Milestones in the Hepatitis C Virus Care Cascade

Zucker, Jason; Aaron, Justin G.; Feller, Daniel; Słowikowski, J; Evans, Henry Ridgely; Scherer, Matthew; Yin, Michael T.; Gordon, Peter

doi:10.1093/ofid/ofy153

Cited by 11 publications

(5 citation statements)

References 11 publications

(14 reference statements)

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“…Identifying DM patients with unrecognized HCV infection may not only help improve their glycemic control [ 37 ] but also further lowers their risk of developing liver-related complications [ 4 , 38 , 39 ] after successful HCV eradication. Through the screening and referral program in the present study, we could achieve a higher HCV screening and treatment rate than those in previous reports [ 1 , 40 , 41 ]. Such an approach may pave the way for improved HCV care and is key to facilitating the HCV care cascade, particularly for the target patient population from non-hepatology departments in the present study.…”

Section: Discussionmentioning

confidence: 45%

Strategy for the Micro-Elimination of Hepatitis C among Patients with Diabetes Mellitus—A Hospital-Based Experience

Chen

Yen

et al. 2021

JCM

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Hepatitis C virus (HCV) infection can induce insulin resistance, and patients with diabetes mellitus (DM) have a higher prevalence of HCV infection. Patient outcomes improve after HCV eradication in DM patients. However, HCV micro-elimination targeting this population has not been approached. Little is known about using electronic alert systems for HCV screening among patients with DM in a hospital-based setting. We implemented an electronic reminder system for HCV antibody screening and RNA testing in outpatient departments among patients with DM. The screening rates and treatment rates at different departments before and after system implementation were compared. The results indicated that the total HCV screening rate increased from 49.3% (9505/19,272) to 78.2% (15,073/19,272), and the HCV-RNA testing rate increased from 73.4% to 94.2%. The anti-HCV antibody seropositive rate was 5.7%, and the HCV viremia rate was 62.7% in our patient population. The rate of positive anti-HCV antibodies and HCV viremia increased with patient age. This study demonstrates the feasibility and usefulness of an electronic alert system for HCV screening and treatment among DM patients in a hospital-based setting.

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Section: Discussionmentioning

confidence: 45%

Strategy for the Micro-Elimination of Hepatitis C among Patients with Diabetes Mellitus—A Hospital-Based Experience

Chen

Yen

et al. 2021

JCM

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“…Approaches and limitations of using proxy measures to measure treatment outcomes have been described previously. 15,16 More than 30% of patients seen at HCV-TAC partner sites (1360 of 3932) who started treatment did not have follow-up HCV RNA results 12 weeks after their estimated treatment completion date; as such, the percentage of patients identified as cured was likely underestimated.…”

Section: Limitationsmentioning

confidence: 99%

Design of an Enhanced Public Health Surveillance System for Hepatitis C Virus Elimination in King County, Washington

et al. 2019

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Introduction: With the goal of eliminating hepatitis C virus (HCV) as a public health problem in Washington State, Public Health–Seattle & King County (PHSKC) designed a Hepatitis C Virus Test and Cure (HCV-TAC) data system to integrate surveillance, clinical, and laboratory data into a comprehensive database. The intent of the system was to promote identification, treatment, and cure of HCV-infected persons (ie, HCV care cascade) using a population health approach. Materials and Methods: The data system automatically integrated case reports received via telephone and fax from health care providers and laboratories, hepatitis test results reported via electronic laboratory reporting, and data on laboratory and clinic visits reported by 6 regional health care systems. PHSKC examined patient-level laboratory test results and established HCV case classification using Council of State and Territorial Epidemiologists criteria, classifying patients as confirmed if they had detectable HCV RNA. Results: The data enabled PHSKC to report the number of patients at various stages along the HCV care cascade. Of 7747 HCV RNA-positive patients seen by a partner site, 5377 (69%) were assessed for severity of liver fibrosis, 3932 (51%) were treated, and 2592 (33%) were cured. Practice Implications: Data supported local public heath surveillance and HCV program activities. The data system could serve as a foundation for monitoring future HCV prevention and control programs.

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“…Of the approximately 3.5 million people estimated to have chronic HCV infection, only 50% are aware of their diagnosis, 16% have been prescribed treatment, and only 9% have achieved sustained virologic response (SVR) . Men outnumber women in terms of prevalent HCV cases, but young persons who inject drugs include a substantial proportion of women of reproductive age .…”

Section: Epidemiology Of Hepatitis C Virus Among Women Of Childbearinmentioning

confidence: 99%

Hepatitis C in Pregnancy: A Unique Opportunity to Improve the Hepatitis C Cascade of Care

Kushner

Terrault

2018

Hepatol Commun

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Development and Validation of an Electronic Medical Record–Based Algorithm to Identify Patient Milestones in the Hepatitis C Virus Care Cascade

Cited by 11 publications

References 11 publications

Strategy for the Micro-Elimination of Hepatitis C among Patients with Diabetes Mellitus—A Hospital-Based Experience

Strategy for the Micro-Elimination of Hepatitis C among Patients with Diabetes Mellitus—A Hospital-Based Experience

Design of an Enhanced Public Health Surveillance System for Hepatitis C Virus Elimination in King County, Washington

Hepatitis C in Pregnancy: A Unique Opportunity to Improve the Hepatitis C Cascade of Care

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