Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate

Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study

“…Glomerular filtration rate was estimated by the CKD-EPI equation (eGFR) 37 . For an additional sensitivity analysis eGFR was also calculated by a recently proposed novel equation 19 .…”

Reassessing the Inclusion of Race in Diagnosing Kidney Diseases: An Interim Report From the NKF-ASN Task Force

“…The ramifications of changes in eGFR equations on research studies examining kidney diseases in African Americans and all other races/ethnicities, how such changes might affect US FDA approval and labeling of therapies, and Noncreatinine Biomarker Used Estimation and reporting with creatinine and race using existing equations Estimation with cystatin C, creatinine, and race using existing equations (1) eGFR cr (MDRD or CKD-EPI) (age, sex, race) with "Black" estimate reported for self-identified African Americans and "non-Black" estimate reported for persons from other communities 8,10,a (13) eGFR cr-cys (CKD-EPI) (age, sex, race) with "Black" estimate reported for self-identified African Americans and "non-Black" estimate reported for persons from other communities 12 Estimation with creatinine and race using existing equations but reporting without specification of race Estimation with cystatin C, creatinine, and race using existing equations but reporting without specification of race (2) eGFR cr (CKD-EPI) (age, sex, race) with "Black" estimate reported as "high muscle mass," and "non-Black" estimate reported as "low muscle mass" a (14) eGFR cr-cys (CKD-EPI) (age, sex, race) with "Black" estimate reported as "high muscle mass," and non-Black estimate reported as "low muscle mass" (3) eGFRcr (CKD-EPI) (age, sex, race) with "Black" estimate reported as "high value," and "White" reported as "low value" a (15) eGFRcr-cys (CKD-EPI) (age, sex, race) with "Black" estimate reported as "high value," and "White" reported as "low value" a (4) eGFR cr (CKD-EPI) (age, sex, race) with the Black coefficient ignored and eGFR value for White/other reported for all (16) eGFR cr-cys (CKD-EPI) (age, sex, race) with the Black coefficient ignored and eGFR value for White/Other reported for all (5) eGFRcr (CKD-EPI) (age, sex, race), with the Black coefficient used and eGFR value for African Americans reported for all (17) eGFRcr-cys (CKD-EPI) (age, sex, race), with the Black coefficient used and eGFR value for African Americans reported for all (6) Blended eGFR cr (CKD-EPI) (age, sex, race) using a single coefficient weighted for percentage of African Americans in the specific population reported for all (18) Blended eGFR cr-cys (CKD-EPI) (age, sex, race) using a single coefficient weighted for percentage of African Americans in the specific population reported for all Estimation with creatinine that do not include race Estimation with cystatin C only (7) CG estimated creatinine clearance (age, sex, weight) 6,a,b (19) eGFR cys (CKD-EPI) (age, sex) 76,a (8) eGFRcr (FAS) (age, sex) 91 (20) eGFRcys (FAS) (age, sex) 92 ( 9) eGFRcr (EKFC) (age, sex) 93 (10) eGFR (LM) (age, sex) 95 (21) eGFRcys (CAPA) (age) 94 Equations to be developed to estimate GFR with creatinine that do not include race Equations to be developed to estimate GFR with creatinine and cystatin C that do not include race (11) eGFRcr refit without race variable (12) eGFRcr refit with height and weight without race variable (22) eGFRcr-cys refit without race variable Estimation with creatinine and cystatin C that does not include race (23) eGFRcr-cys (FAS) (age, sex) 92 Estimations with new filtr...…”

Estimating glomerular filtration rate: a systematic comparison of the new European Kidney Function Consortium equation with the Chronic Kidney Disease Epidemiology Collaboration equation

“…The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is the most commonly used equation for estimating glomerular filtration rate (GFR). Recently the European Kidney Function Consortium (EKFC) formula with an extended age range from 2 to 90 years was published [ 1 ]. In the study validation cohort, it predicted measured GFR in adults with low bias and greater accuracy and precision than the CKD-EPI equation [ 1 ].…”

“…This is an entirely mathematical comparison between the EKFC [ 1 ] and CKD-EPI (non-black) equations [ 2 ]. We created contour plots ( Figure 1 ) for absolute and relative differences across the age range 18–90 years ( x -axis) and CKD-EPI values from 1 to 104 mL/min/1.73 m 2 ( y -axis).…”

“…We clearly demonstrate that for most patients with impaired kidney function, the differences between these two equations are minor and generally smaller than the imprecision of these formulas for the true, measured GFR [ 1 ]. We predict that, for example, for drug dose adaptions, the choice of formula will not lead to clinically significant differences.…”