Development and validation of a predictive model for post-percutaneous nephrolithotomy urinary sepsis: a multicenter retrospective study

WANG, Leibo; LI, Daobing; HE, Wei; SHI, Guanyu; ZHAI, Jianpo; CEN, Zhuangding; XU, Feng; XIE, Hao; YU, Zhibing; ZHAO, Guoqiang; MO, Chishou; LV, Qi; TIAN, Wu

doi:10.23736/s2724-6051.23.05396-x

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…A study by Erdogan et al reached similar conclusions [ 15 , 16 ]. Many studies have focused on finding risk factors for complications of SIRS and sepsis after PNL [ [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] ], including female sex, diabetes mellitus, volume of renal stones, degree of hydronephrosis, density of hydronephrosis, urinary leukocytes, positive urine cultures and elevated blood neutrophils. There is still no precise stratified scoring system or comprehensive model to predict preoperative calculous obstructive pyonephrosis before PNL.…”

Section: Discussionmentioning

confidence: 99%

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Construction of an alignment diagram model for predicting calculous obstructive pyonephrosis before PNL

Liu,

zhuang

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

“…), which promote the conversion of the urinary protein product nitrate to nitrite. Leibo Wang et al demonstrated that a positive urinary UN proved to be a good diagnostic for renal pyonephrosis [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Construction of an alignment diagram model for predicting calculous obstructive pyonephrosis before PNL

Liu,

zhuang

et al. 2024

Heliyon

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“…Urolithiasis stands as a prevalent ailment in urology, with the worldwide incidence of urinary stones ranging from 1 to 20%, and specifically within China, it falls between 1 and 5% (1,2). The global prevalence of urolithiasis has been on the rise, attributed to shifts in dietary patterns, socioeconomic factors, and climatic variations (3). Notably, the recurrence rate within a decade following treatment is notably high, hovering around 50% (4).…”

Section: Introductionmentioning

confidence: 99%

Influence of preoperative urine culture and bacterial species on urogenital sepsis after ureteral flexible lithotripsy in patients with upper urinary tract stones

Wang,

Yu,

Qiu

et al. 2024

Front. Med.

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ObjectiveThis retrospective study aims to identify risk factors for urogenic sepsis in patients with upper urinary tract stones following ureteral flexible lithotripsy (FURL). Additionally, we analyze the clinical characteristics of bacterial infections post-surgery.MethodsA total of 759 patients who underwent FURL at the Urology Department of Zunyi Medical University were included. Univariate and multivariate Logistic regression analyses were conducted to identify independent risk factors for urogenic sepsis post-FURL. The distribution of bacteria based on preoperative urine cultures was also analyzed. Statistical analysis was performed using R4.2.2 software.ResultsOf the 759 patients, positive preoperative urine culture, urine nitrite positivity, urine white blood cell count (WBC) ≥ 200 cells/μL, residual stones, and neutrophil-to-lymphocyte ratio (NLR) were found to be independent risk factors for urogenic sepsis after FURL. Among the 164 patients with positive preoperative urine cultures, 32 developed urogenic sepsis post-surgery, with 68.75% having positive preoperative cultures. The leading pathogens causing postoperative urogenic sepsis were Escherichia coli (E. coli), Enterococcus faecium, Proteus mirabilis, and Klebsiella pneumoniae. The probabilities of progression to urogenic sepsis were as follows: E. coli 19% (n = 12), Enterococcus faecium 43% (n = 3), Proteus mirabilis 33.3% (n = 1), and Klebsiella pneumoniae 33.3% (n = 1). The ages of affected patients were 47.17 ± 13.2, 53.7, 41, and 79 years, respectively. Rates of comorbid diabetes were 36.4, 66.7, 50, 100%, with nitrite positivity rates at 72.7, 33.3, 50, 0%. Ten female patients were infected with E. coli, while patients infected with Klebsiella pneumoniae had an NLR of 7.62.ConclusionPositive preoperative urine culture, urine nitrite positivity, urine WBC ≥ 200 cells/μL, residual stones, and NLR are independent risk factors for urogenic sepsis after FURL. Escherichia coli is the predominant pathogen post-FURL, with notable female prevalence and nitrite-positive urine in infections. Enterococcus faecium infections are associated with diabetes.

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External validation of a nomogram for outcome prediction in management of medium-sized (1-2 cm) kidney stones

SIGHINOLFI,

CALCAGNILE,

TICONOSCO

et al. 2024

Minerva Urol Nephrol

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Development and validation of a predictive model for post-percutaneous nephrolithotomy urinary sepsis: a multicenter retrospective study

Cited by 5 publications

References 29 publications

Construction of an alignment diagram model for predicting calculous obstructive pyonephrosis before PNL

Construction of an alignment diagram model for predicting calculous obstructive pyonephrosis before PNL

Influence of preoperative urine culture and bacterial species on urogenital sepsis after ureteral flexible lithotripsy in patients with upper urinary tract stones

External validation of a nomogram for outcome prediction in management of medium-sized (1-2 cm) kidney stones

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