Development and Validation of a Novel All-Inclusive LC–MS-MS Designer Drug Method

Interpol Review of Drug Analysis 2019-2022

“…2019 separation with Magneto-Archimedes levitation (MagLev), followed by characterization by FTIR-ATR of powdered mixtures of illicit drugs (cocaine, MA, heroin, fentanyl, and its analogues), adulterants, and diluents based on density, for the presumptive identification of individual components [ 852 ]; SERS for the detection of illegal injectables [ 853 ]; study investigates the prevalence of drugs of abuse detected from 2011 to 2015 through forensic drug testing of illicit drug seizures from law enforcement agencies [ 854 ]; ambient mass spectrometry and LC-MS/MS for the rapid detection and identification of multiple illicit street drugs [ 855 ]; rapid analytical method using an Orbitrap mass spectrometer for identification of 32 illicit drugs in marketed products was developed (included benzodiazepine-, synthetic cannabinoid-, amphetamine- and benzylpiperazine-type drugs) [ 856 ]; Thermal Desorption Direct Analysis in Real Time Mass Spectrometry (TD-DART-MS) for the simultaneous detection of rodenticides and drugs in seized drug mixtures [ 857 ]; Capillary Microextraction-Mass Spectrometry (CME-MS) method for the analysis of Illicit Drugs [ 858 ]; LC-MS/MS method for designer drugs that combines synthetic cannabinoids and synthetic cathinones, etizolam, a designer benzodiazepine and mitragynine (kratom) [ 859 ]; review of the epidemiology, chemistry, pharmacophysiology, clinical effects, laboratory detection, and clinical treatment for newly emerging drugs of abuse in the following classes: (1) opioids (2) cannabinoids (3) stimulants and hallucinogens (4) dissociative agents and (5) sedative-hypnotics [ 860 ]; type and purity analysis of seizured illicit substances (screened by GC-MS and LC-MS/MS followed by GC-FID for quantitative analyses) [ 861 ]; TD acetone-assisted photoionization miniature ion trap mass spectrometer was developed for on-site and rapid identification of illegal drugs at checkpoints [ 862 ]; a synchronized flash-thermal-desorption purging and ion injection (SFTDPI) method to increase the sensitive and rapid screening of volatile and nonvolatile illegal drugs for miniature ion trap mass spectrometry (ITMS) [ 863 ]; vacuum filtration-paper chromatography-SERS (VF-PC-SERS) for field analysis of illicit materials [ 864 ]; 2020 Evaluation of seized performance enhancing drugs in Isreaal from 2012 to 2017 [ 865 ]; integration of SERS and PSI-MS to enable on-site chemical analysis by two independent methods for on-site illicit drug confirmation [ 866 ]; feasibility study to examine creating mutant protein arrays capable of detecting drugs of abuse in solution or in vapor phase [ 867 ]; high-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) applying different ionization sources such as paper spray ionization (PSI) and electrospray ionization (ESI) in the evaluation of seized drugs samples on blotter paper (n = 79) and tablet (n = 100) [ 868 ]; two paper electrospray ionization quadrupole-orbitrap mass spectrometer screening procedures for detection of drugs of abuse, pharmaceuticals and chemical warfare agents in soil by...…”

Determination of Synthetic Cathinones in Urine and Oral Fluid by Liquid Chromatography High-Resolution Mass Spectrometry and Low-Resolution Mass Spectrometry: A Method Comparison

“…When these substances are consumed, they can be present in different biological samples and they have become very important in toxicological and forensic analyses [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Although in these samples it is possible to find the parent drug and its metabolites, it is usually the latter that remain longer in the body.…”

“…The trend is to use MS as a detection system to obtain methods with high sensitivity. Low-resolution MS, such as tandem MS (MS/MS), and high-resolution MS (HRMS) have become the preferred choices in recent years [6][7][8][9][11][12][13][14][15][16][17][18][19][20]. In the case of MS/MS, there are several examples using triple quadrupole (QqQ) or ion trap MS (QTrap) [6,7,[11][12][13][14][15][16].…”

“…Low-resolution MS, such as tandem MS (MS/MS), and high-resolution MS (HRMS) have become the preferred choices in recent years [6][7][8][9][11][12][13][14][15][16][17][18][19][20]. In the case of MS/MS, there are several examples using triple quadrupole (QqQ) or ion trap MS (QTrap) [6,7,[11][12][13][14][15][16]. For HRMS, Orbitrap, QOrbitrap, and quadrupole time-of-flight (QToF) are the most used detectors [8,9,[17][18][19][20].…”