Development and validation of a novel detection method for Rickettsia rickettsii using a loop-mediated isothermal amplification assay
Bertha I. Carvajal-Gamez,
Aída Olguín-Barrera,
Luis Tinoco-Gracia
et al.
Abstract:IntroductionRickettsia rickettsii is an obligate, intracellular pathogen and the causative agent of Rocky Mountain spotted fever (RMSF). RMSF is an important zoonotic disease due to its high fatal outcome in humans. The difficulty of clinical diagnosis due to the low sensitivity and specificity of current diagnostic methods are a principal setback. We reported the development of a new method for the detection of R. rickettsii in human and tick DNA samples using loop-mediated isothermal amplification (LAMP), as… Show more
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