Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts

Beyer, Georg; Mahajan, Ujjwal Mukund; Budde, Christoph; Bulla, Thomas; Kohlmann, Thomas; Kuhlmann, Louise; Schütte, Kerstin; Aghdassi, Ali; Weber, Eckhard; Weiss, Frank Ulrich; Drewes, Asbjørn Mohr; Olesen, Søren Schou; Lerch, Markus M.; Mayerle, Julia

doi:10.1053/j.gastro.2017.08.073

Cited by 44 publications

(31 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Following title and abstract screening, 235 full-text reviews were conducted and 48 papers were ultimately included in the systematic review ( Fig. 1 Original Scoring Systems [10,[14][15][16][17][18][19][20][21][22][23] Eleven studies described original scores that collected patient parameters to classify patients into severity groups or clinical stages (or to assign a score for severity). The studies included a minimum of 2 parameters (Table 1).…”

Section: Search Resultsmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

“…The most recently published score, CP Prognosis Score, has been prospectively validated to be able to predict important outcomes [23]. During the development of CP Prognosis Score, an array of biochemical and clinical parameters were analysed in patients with an unequivocal diagnosis of CP [23]. Bivariate correlations were determined and the resulting system accurately discriminated patients into stages of disease severity from low to high and predicted risk for hospitalisation and length of stay.…”

Section: Discussion/conclusionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Classification and Severity Scoring Systems in Chronic Pancreatitis: A Systematic Review

et al. 2019

View full text Add to dashboard Cite

Introduction: Chronic pancreatitis (CP) is characterised by pain, functional deficits, nutritional and mechanical complications. Frequently managed in out-patient settings, the clinical course is unpredictable and requires multi-disciplinary care. There remains substantial variation in management. In contrast to acute pancreatitis, there are no globally accepted classification or severity scores to predict the disease course or compare interventions. We conducted a systematic review to determine the scope and clinical use of existing scoring systems. Methods: A systematic search was developed with a medical librarian using the Embase, Medline and Cochrane databases. Original articles and conference abstracts describing an original or modified classification or scoring system in CP that stratified patients into clinical and/or severity categories were included. To assess clinical application/validation, studies using all or part of a score as a stratification tool to measure another parameter or outcome were selected. Studies reporting on diagnosis or aetiology only were excluded. Four authors performed the search in independent pairs and conflicts were resolved by a fifth author using Covidence TM systematic review software. Results: Following screening 6,652 titles and 235 full-text reviews, 48 papers were analysed. Eleven described original scores and 6 described modifications of published scores. Many were comprehensive but limited in capturing the full spectrum of disease. In 31 studies, a score was used to categorise patients to compare or correlate various outcome measures. Exocrine and endocrine dysfunction and pain were included in 6, 5, and 4 scoring systems, respectively. No score included other nutrition parameters, such as bone health, malnutrition, or nutrient deficiency. Only one score has been objectively validated prospectively and independently for monitoring clinical progression and prognosis, but this had been applied to an in-patient population. Conclusion: Available systems and scores do not reflect recent A.R. and D.B.O.C. contributed equally to the manuscript. Rahman et al.advances and guidelines in CP and are not commonly used. A practical clinical classification and scoring system, validated prospectively for prognostication would be useful for the meaningful analysis in observational and interventional studies in CP.

show abstract

Section: Search Resultsmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Classification and Severity Scoring Systems in Chronic Pancreatitis: A Systematic Review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…A relevant role for CRP, a marker of acute phase reaction, has been recently reported not only as a prognostic variable associated with CP course 43 , but also as a marker of decreased bone density 4 . In the present study, however, CRP levels were not associated with BMD.…”

Section: Discussionmentioning

confidence: 99%

Vitamins D and K as Factors Associated with Osteopathy in Chronic Pancreatitis: A Prospective Multicentre Study (P-BONE Study)

Stigliano

Waldthaler

Martínez-Moneo

et al. 2018

Clinical and Translational Gastroenterology

View full text Add to dashboard Cite

BackgroundOsteopathy is common in patients with chronic pancreatitis (CP), but previous studies carry several limitations. Vitamin K is essential for bone metabolism, but its role in this setting has never been investigated. Our aim is to assess the prevalence of osteoporosis and osteopenia in CP patients, and to investigate the association between osteopathy and CP features and nutritional parameters, especially vitamin D and K levels.MethodsMulticentre cross-sectional study on CP patients diagnosed according to M-ANNHEIM criteria. Bone density was evaluated by dual-energy X-ray absorptiometry and pancreatic function by faecal elastase. Nutritional evaluation included vitamin D and vitamin K. Differences between patients with or without osteopathy were evaluated. The association between investigated variables and bone density were analysed with logistic regression analysis.ResultsIn total, 211 CP patients were enrolled at eight Centres (67% men; mean age 60). In total, 18% had advanced-marked CP, 56% suffered from pancreatic exocrine insufficiency and disease aetiology was alcoholic in 43%. Vitamin D and K were deficient in 56% and 32%, respectively. Osteopenia was diagnosed in 42% and osteoporosis in 22%. In the multivariate analysis, female sex (OR 2.78), age (OR 1.07 per year) and higher BMI (OR 0.84) were associated with the presence of osteoporosis. In male patients, the only factor associated with osteoporosis was vitamin K deficiency (OR 4.23).ConclusionThe present data confirm a high rate of osteopathy in CP patients and highlight the relevance of vitamin K deficiency as only factor associated with osteoporosis in male patients for the first time.

show abstract

“…COPPS helped to determine the risk for readmission to hospital and potential length of hospital stay. 6 CP increases the risk of pancreatic cancer. However, in the absence of hereditary predisposition, it remains unclear which subgroup of CP patients would benefit from surveillance.…”

mentioning

confidence: 99%

Disease stratification and outcome prediction in chronic pancreatitis: Can we do better?

Ang

2020

J of Gastro and Hepatol

View full text Add to dashboard Cite

Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts

Cited by 44 publications

References 32 publications

Clinical Classification and Severity Scoring Systems in Chronic Pancreatitis: A Systematic Review

Clinical Classification and Severity Scoring Systems in Chronic Pancreatitis: A Systematic Review

Vitamins D and K as Factors Associated with Osteopathy in Chronic Pancreatitis: A Prospective Multicentre Study (P-BONE Study)

Disease stratification and outcome prediction in chronic pancreatitis: Can we do better?

Contact Info

Product

Resources

About