Development and Validation of a Predictive Scoring System for Colorectal Cancer Patients With Liver Metastasis: A Population-Based Study

Cao, Yinghao; Ke, Songqing; Deng, Song; Yan, Lizhao; Gu, Jimin; Mao, Fuwei; Xue, Yifan; Zheng, Changmin; Cai, Wentai; Liu, Hongli; Li, Han; Shang, Fumei; Sun, Zhuolun; Wu, Ke; Zhao, Ning; Cai, Kailin

doi:10.3389/fonc.2021.719638

Cited by 6 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Distant organ metastasis (mainly to the liver) is a clinical hallmark of young-onset CRC, accounting for most of the deaths [ 11 ]. Multiple liver metastases, nodules, the degree of differentiation, extrahepatic metastasis, tumor size, CEA level, positive surgical margins, and venous infiltration are all significant predictors of CRLM patient survival [ 12 , 13 , 14 ]. However, clinicopathological characteristics differ significantly between younger and older CRC patients.…”

Section: Discussionmentioning

confidence: 99%

“…Young-onset CRLM patients with rectal and left colon tumors had better outcomes than those with right colon tumors, but there was no significant difference between patients with rectal and left colon tumors. According to a previous study based on the SEER database, CRLM patients with colon primaries had worse survival than those with rectal primaries [ 14 ]. Different from our findings, this suggests that young-onset CLRM patients may have unique prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nomogram Predicting the Survival of Young-Onset Patients with Colorectal Cancer Liver Metastases

Cheng

Chen

et al. 2022

Diagnostics

View full text Add to dashboard Cite

Background: Although the global prevalence of colorectal cancer (CRC) is decreasing, there has been an increase in incidence among young-onset individuals, in whom the disease is associated with specific pathological characteristics, liver metastases, and a poor prognosis. Methods: From 2010 to 2016, 1874 young-onset patients with colorectal cancer liver metastases (CRLM) from the Surveillance, Epidemiology, and End Results (SEER) database were randomly allocated to training and validation cohorts. Multivariate Cox analysis was used to identify independent prognostic variables, and a nomogram was created to predict cancer-specific survival (CSS) and overall survival (OS). Receiver operating characteristic (ROC) curve, C-index, area under the curve (AUC), and calibration curve analyses were used to determine nomogram accuracy and reliability. Results: Factors independently associated with young-onset CRLM CSS included primary tumor location, the degree of differentiation, histology, M stage, N stage, preoperative carcinoembryonic antigen level, and surgery (all p < 0.05). The C-indices of the CSS nomogram for the training and validation sets (compared to TNM stage) were 0.709 and 0.635, and 0.735 and 0.663, respectively. The AUC values for 1-, 3-, and 5-year OS were 0.707, 0.708, and 0.755 in the training cohort and 0.765, 0.735, and 0.737 in the validation cohort, respectively; therefore, the nomogram had high sensitivity, and was superior to TNM staging. The calibration curves for the training and validation sets were relatively consistent. In addition, a similar result was observed with OS. Conclusions: We developed a unique nomogram incorporating clinical and pathological characteristics to predict the survival of young-onset patients with CRLM. This may serve as an early warning system allowing doctors to devise more effective treatment regimens.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nomogram Predicting the Survival of Young-Onset Patients with Colorectal Cancer Liver Metastases

Cheng

Chen

et al. 2022

Diagnostics

View full text Add to dashboard Cite

show abstract

“…However, conventional TNM staging often fails to accurately predict patient prognosis. The results of a previous study showed that the maximum AUC value of 5-year OS for patients with CRCLM was 0.627, indicating that TNM staging is not su cient to meet the clinical needs of a speci c population and cannot accurately predict prognosis in CRCLM [39]. In the present study, a clinical prediction model was established based on the results of multivariate cox analysis, and the AUC for 5-year OS reached 0.744.…”

Section: Discussionmentioning

confidence: 59%

Lymphovascular invasion affects prognosis of colorectal cancer liver metastasis underwent primary resection: a propensity score matching analysis

li,

Liu,

Xiang

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Lymphovascular invasion (LVI) is associated with poor prognosis in a variety of malignancies; however, its prognostic value has not been fully defined in patients with colorectal cancer with liver metastases (CRCLM). The aim of this study was to investigate the impact of lymphovascular invasion on long-term postoperative recurrence and survival in patients with CRCLM. Methods：Clinicopathologic data were retrospectively collected from patients who underwent primary resection for CRCLM at Wuhan Union Hospital from 2013 to 2018. To reduce potential confounders and selection bias, we used propensity score matching (PSM) to compare the clinicopathologic characteristics and long-term prognostic outcomes of patients in the LVI(+) and LVI(-) groups. Cox unifactorial and multifactorial analyses were used to screen relevant factors affecting patient prognosis, and Kaplan-Meier curves were plotted to compare differences in patient OS and DFS. The predictive power of independent factors on patients' long-term prognosis was assessed using receiver operating characteristic ROC) curves and area under the curve (AUC). Results: After PSM, 230 patients were enrolled in the study (n=115 per group). Multifactorial analysis revealed that LVI was an independent prognostic factor for OS and DFS (hazard ratio [HR], 1.424; 95% confidence interval [CI], 1.004–2.022; P=0.048 and HR, 1.452; 95% CI, 1.020–2.069; p=0.039, respectively). In the LVI(-) group, postoperative chemotherapy did not significantly improve OS or DFS; however, in the LVI(+) group, those who received chemotherapy had significantly improved OS (HR: 2.424 , 95% CI: 1.471−3.992; P=0.00034) and DFS (HR: 2.164, 95% CI. 1.328−3.525; P=0.0014) compared with patients not treated with chemotherapy. In the LVI(+) group, the AUC for the OS AUROC curves was more favorable compared with after PSM (AUC at 3 years: 0.786 vs 0.903; AUC at 5 years: 0.744 vs 0.889). For DFS, the area under the AUROC curve was also better in the LVI(+) subgroup compared with after PSM (AUC at 3 years: 0.874 vs 0.786; AUC at 5 years: 0.863 vs 0.744). Conclusions: LVI significantly impacts long-term survival and prognosis in patients with CRLM undergoing primary resection and is an independent prognostic factor for OS and DFS. Postoperative chemotherapy significantly improved the long-term prognosis of patients with LVI(+).

show abstract

“…TBS was defined as the distance from the origin of a Cartesian plane using maximum tumor size as the X-axis and tumor number as the Y-axis (9). As previously reported, TBS is a valuable tool in evaluating prognosis for colorectal liver metastases, HCC, and ICC (13,26,27). The present study assessed the significance of TBS in dictating the prognosis of patients with cHCC-CCA after curative liver resection.…”

Section: Discussionmentioning

confidence: 77%

Tumor burden score dictates prognosis of patients with combined hepatocellular cholangiocarcinoma undergoing hepatectomy

et al. 2023

View full text Add to dashboard Cite

BackgroundThe prognostic value of the tumor burden score (TBS) in patients with combined hepatocellular-cholangiocarcinoma (cHCC-CCA) remains unknown. This study aimed to investigate the impact of TBS on long-term outcomes after surgery.MethodsPatients who underwent radical-intent resection between June 2013 and December 2019 were retrospectively reviewed. Kaplan–Meier curves were used to analyze patient survival, and disease-free survival (DFS) and overall survival (OS) were examined in relation to TBS.ResultsA total of 178 patients were included in this study, with 119 in the training cohort and 59 in the validation cohort. Kaplan–Meier curves showed that TBS was a strong prognostic indicator in patients with cHCC-CCA. Elevated TBS was associated with poorer DFS and OS (both P-value < 0.001) and was identified as an independent prognostic indicator. In addition, the prognostic value of TBS outperformed tumor size and number alone, microvascular invasion, and lymph node invasion. The prognostic significance of TBS was confirmed by the internal validation cohort.ConclusionsThe present study suggested the significance of tumor morphology in assessing the prognosis of patients with cHCC-CCA who undergoing curative resection. The TBS is a promising prognostic index in patients with cHCC-CCA. Elevated TBS was related to a lower long-term survival rate and was identified as an independent risk factor for poor DFS and OS. Further research is needed to verify our results.

show abstract

Development and Validation of a Predictive Scoring System for Colorectal Cancer Patients With Liver Metastasis: A Population-Based Study

Cited by 6 publications

References 23 publications

Nomogram Predicting the Survival of Young-Onset Patients with Colorectal Cancer Liver Metastases

Nomogram Predicting the Survival of Young-Onset Patients with Colorectal Cancer Liver Metastases

Lymphovascular invasion affects prognosis of colorectal cancer liver metastasis underwent primary resection: a propensity score matching analysis

Tumor burden score dictates prognosis of patients with combined hepatocellular cholangiocarcinoma undergoing hepatectomy

Contact Info

Product

Resources

About