Development and Validation of a Method for Determining Lidocaine Hydrochloride and Miramistin in an Innovative Wound-Healing Gel

An isocratic RP-HPLC-UV method for simultaneous quantification of tizanidine and lidocaine: application to in vitro release studies of a subcutaneous implant

“…21 Additionally, other validated methods exist for determining the drug in polymeric matrices, [26][27][28] plasma, 29,30 and in new topical dosage forms. 25,[31][32][33] Methods for the quan-tication of TZ, on the other hand, were described for analysing the drug alone, 34,35 concurrently with other drugs like muscle relaxants, 36 analgesics, [37][38][39] and anti-inammatories, [40][41][42][43][44][45][46][47][48] and from pharmaceutical formulations. 2,38,42,[44][45][46][47][48][49][50][51] Moreover, a method has been described for detecting TZ in skin deposition 52 and plasma.…”