Development and Validation of a Questionnaire to Assess Social Participation of High Risk-Adults in Germany During the COVID-19 Pandemic

Schröder, Dominik; Heesen, Gloria; Heinemann, Stephanie; Hummers, Eva; Jablonka, Alexandra; Steffens, Sandra; Mikuteit, Marie; Niewolik, Jacqueline; Overbeck, Tobias R.; Kallusky, Jonathan; Müller, Frank

doi:10.3389/fpubh.2022.831087

Cited by 5 publications

(8 citation statements)

References 43 publications

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“…The recruitment is ongoing. We developed a questionnaire to assess social participation during a pandemic [ 18 ], which will be tested within DEFEAT Corona.…”

Section: Discussionmentioning

confidence: 99%

Long-term Consequences of COVID-19 and the Pandemic: Protocol for a Web-Based, Longitudinal Observational Study (DEFEAT)

Mikuteit¹,

Heinemann²,

Roder³

et al. 2022

JMIR Res Protoc

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Background With population-wide vaccination availability, the global COVID-19 pandemic entered a new phase. Despite vaccination status, some people who were infected with SARS-CoV-2 experience long-term symptoms. Objective In this study, we aim to characterize the long-term effects of SARS-CoV-2 infection and the pandemic. We also aim to build symptom clusters and determine risk factors for developing long COVID symptoms. Furthermore, we assess social participation and health-related quality of life in patients with long COVID and in the general population during a global pandemic. Methods With a mixed-methods, web-based approach, we aim to recruit 2000 people in Germany who are older than 18 years and can provide informed consent. In the quantitative arm of the study, we identify symptoms of and predictive factors for long COVID manifestations with cluster analysis and assess social participation during the pandemic with standardized questionnaires. The qualitative arm of the study uses individual interviews and focus group discussions to better understand the illness experience of persons who experience long COVID. Results Recruitment started in September 2021. Up until July 2022, we recruited approximately 4500 participants via our web-based database. Conclusions This study aims to build an innovative, patient-centered, web-based research platform appropriate for the pandemic by minimizing physical contact between study personnel and participants. All study activities are designed to better understand the long COVID syndrome, social participation during the pandemic, and the illness experiences of persons affected by long COVID. Trial Registration German Clinical Trial Registry DRKS00026007; https://tinyurl.com/yh282fkt International Registered Report Identifier (IRRID) DERR1-10.2196/38718

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“…The recruitment is ongoing. We developed a questionnaire to assess social participation during a pandemic [ 18 ], which will be tested within DEFEAT Corona.…”

Section: Discussionmentioning

confidence: 99%

Long-term Consequences of COVID-19 and the Pandemic: Protocol for a Web-Based, Longitudinal Observational Study (DEFEAT)

Mikuteit¹,

Heinemann²,

Roder³

et al. 2022

JMIR Res Protoc

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“…The measure for social participation is the validated Pandemic Social Participation Questionnaire (PSP-Q) [ 23 ]. It was developed in 2020 during the first year of the COVID-19 pandemic to reflect social participation in the pandemic setting.…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, the subjective current health status was collected using one item with a five-point Likert scale (1 = best health; 5 = worst health). Detailed information on data collection can be found in Schröder et al [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

How do immunocompromised people experience the changes in their working lives during the COVID-19 pandemic? Results from a mixed-methods study in Germany

Wegener,

Hummers,

Müller

et al. 2023

Heliyon

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“…SARS-CoV-2 infection causes direct damage to multiple organs. With varying symptoms, LoCo also influences physical and cognitive function, quality of life, and everyday activity (Yuan et al 2023 , Schröder et al 2022 ). The systemic, multi-organ feature of COVID-19 prompted investigations on SARS-CoV-2 infection using metabolomic studies (Bruzzone et al 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Amino acids, post-translational modifications, nitric oxide, and oxidative stress in serum and urine of long COVID and ex COVID human subjects

et al. 2023

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In this study, we investigated the status of amino acids, their post-translational modifications (PTM), major nitric oxide (NO) metabolites and of malondialdehyde (MDA) as a biomarker of oxidative stress in serum and urine samples of long COVID (LoCo, n = 124) and ex COVID (ExCo, n = 24) human subjects collected in 2022. Amino acids and metabolites were measured by gas chromatography–mass spectrometry (GC–MS) methods using stable-isotope labelled analogs as internal standards. There were no differences with respect to circulating and excretory arginine and asymmetric dimethylarginine (ADMA). LoCo participants excreted higher amounts of guanidino acetate than ExCo participants (17.8 ± 10.4 µM/mM vs. 12.6 ± 8.86 µM/mM, P = 0.005). By contrast, LoCo participants excreted lower amounts of the advanced glycation end-product (AGE) NG-carboxyethylarginine (CEA) than ExCo participants did (0.675 ± 0.781 µM/mM vs. 1.16 ± 2.04 µM/mM, P = 0.0326). The serum concentrations of MDA did not differ between the groups, indicating no elevated oxidative stress in LoCo or ExCo. The serum concentration of nitrite was lower in LoCo compared to ExCo (1.96 ± 0.92 µM vs. 2.56 ± 1.08 µM; AUC, 0.718), suggesting altered NO synthesis in the endothelium. The serum concentration of nitrite correlated inversely with the symptom anxiety (r = − 0.293, P = 0.0003). The creatinine-corrected urinary excretion of Lys and its metabolite L-5-hydroxy-Lys correlated positively with COVID toes (r = 0.306, P = 0.00027) and sore throat (r = 0.302, P = 0.0003). Our results suggest that amino acid metabolism, PTM and oxidative stress are not severely affected in long COVID. LoCo participants may have a lower circulating NO reservoir than ExCo.

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Development and Validation of a Questionnaire to Assess Social Participation of High Risk-Adults in Germany During the COVID-19 Pandemic

Cited by 5 publications

References 43 publications

Long-term Consequences of COVID-19 and the Pandemic: Protocol for a Web-Based, Longitudinal Observational Study (DEFEAT)

Long-term Consequences of COVID-19 and the Pandemic: Protocol for a Web-Based, Longitudinal Observational Study (DEFEAT)

How do immunocompromised people experience the changes in their working lives during the COVID-19 pandemic? Results from a mixed-methods study in Germany

Amino acids, post-translational modifications, nitric oxide, and oxidative stress in serum and urine of long COVID and ex COVID human subjects

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