Development and Validation of a New Analytical Method for the Determination of Related Components in Tolterodine Tartarate Using LC

Evaluation of microwave oven heating for prediction of drug–excipient compatibilities and accelerated stability studies

“…Although numerous reports concerning microwave-assisted organic synthesis are available, only a few examples could be found in the literature, where a microwave oven has been used for accelerated stability studies (Madhavi et al, 2008;Prekodavac et al, 2011;Sonawane and Gide, 2011). The utilization of the microwave oven for generating accelerated stability data entails that the same impurities are formed and no additional impurities are detected during HPLC-UV and HPLC-MS analysis.…”

“…This opens up for the possibility of investigating reactions at high temperatures in standard HPLC vials, which can be transferred directly to an HPLC instrument with the use of minimal sample quantities and generation of impurities in a shorter amount of time. Despite the considerable effort placed in the investigation of microwave ovens for organic synthesis, only scattered examples exist in the literature, where a microwave oven has been used for accelerated stability studies (Madhavi et al, 2008;Prekodavac et al, 2011;Sonawane and Gide, 2011). These studies only comprise one API each, which has been subjected to microwave-assisted forced degradation such as acid or alkali catalysed degradation.…”

Electrically-enhanced microextraction combined with maltodextrin-modified capillary electrophoresis for quantification of tolterodine enantiomers in biological samples

“…Common methods that have been used for routine analysis of TOL enantiomers were chromatographic and immunoassay techniques [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. In all these methods, the problem of sample pretreatment 8.…”

“…Determination of TOL has already been carried out using chromatographic methods such as gas chromatography-mass spectrometry (GC-MS) [7], capillary electrophoresis (CE) [8,9], high performance thin layer chromatography (HPTLC) [10,11] and high performance liquid chromatography (HPLC) with different detectors including tandem mass spectrometry (HPLC-MS-MS) [12][13][14][15], mass spectrometry (HPLC-MS) [16,17], and UV detection (HPLC-UV) [18][19][20][21][22]. But only a few published chromatographic methods are available for the determination of TOL enantiomers [8,9,18,19].…”

Electrochemical Oxidation of Tolterodine

“…Chromatographic methods, especially high performance liquid chromatography coupled to mass spectrometry (HPLC/MS) 6–9 and HPLC with UV detection 10,11 are most frequently used for the determination of tolterodine and its metabolites. Enantiospecific HPLC methods were developed for the determination of ( S )‐enantiomer impurities in ( R )‐tolterodine tartrate 12, 13.…”