Development and validation of a nylon6 nanofibers mat-based SPE coupled with HPLC method for the determination of docetaxel in rabbit plasma and its application to the relative bioavailability study

A Rapid and Sensitive UPLC–MS/MS Method for Determination of Docetaxel in Rabbit Plasma: Pharmacokinetic Study of New Lung-Targeting Docetaxel Liposome at Low Dose

“…To date, the general analytic method for DTX in biological matrices is HPLC [12,[14][15][16][17] and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) [18][19][20][21][22][23][24][25]. The lower limit of quantitation (LLOQ) of HPLC with UV detection assays for DTX analysis has been reported to be 2.5-12.5 ng/ml in plasma [12,[14][15][16][17]. Similar LLOQ of HPLC method was also achieved in our laboratory.…”

“…One potential problem with the use of lower DTX dose is the difficulty in determining drug levels in plasma over a time frame that is necessary for the accurate assay of pharmacokinetic parameters. To date, the general analytic method for DTX in biological matrices is HPLC [12,[14][15][16][17] and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) [18][19][20][21][22][23][24][25]. The lower limit of quantitation (LLOQ) of HPLC with UV detection assays for DTX analysis has been reported to be 2.5-12.5 ng/ml in plasma [12,[14][15][16][17].…”

Electrospun nanofiber-based solid-phase extraction

“…There have been several other reports on the use of nylon 6 nanofibers packed in the same format [70][71][72][73][74]. Similar to the first report by Xu and co-workers [69], all these reports seem to have focussed on demonstrating the feasibility of using electrospun nylon 6 nanofibers as a SPE sorbent material.…”

Novel sample preparation technique based on functional nanofiber mat for sensitive and precise determination of phenolic environmental estrogens in environmental water

“…Electrospinning is the most frequently used method to prepare nanobers. Some researchers, [16][17][18][19] including our group, [20][21][22][23][24] have explored the application of electrospun nanobers as SPE sorbents. As shown in our previous studies, electrospun nanobers have a high surface-to-volume ratio and length-to-diameter ratio, leading to a larger specic surface area and more active sites for adsorption.…”