Development and validation of a coupled head-neck FEM – application to whiplash injury criteria investigation

Meyer, Frank; Bourdet, Nicolas; Gunzel, K.; Willinger, Rémy

doi:10.1080/13588265.2012.732293

Cited by 17 publications

(7 citation statements)

References 34 publications

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“…A neck model including spinal column, spinal cord, dura mater, and neck muscles was incorporated allowing the brain stem to be extended to the spinal cord. Other FEM head/brain biomechanics and injury models include: Simulated Injury Monitor (SIMon) FEM human head model developed by a team lead by Takhounts at the National Highway Traffic Safety Administration (NHTSA) (Takhounts et al, 2003, 2008), the University College Dublin Brain Trauma Model (UCDBTM) (Horgan and Gilchrist, 2008; Colgan et al, 2010), and the Strasbourg University Finite Element Head Model (SUFEHM) (Willinger et al, 1999; Raul et al, 2008; Meyer et al, 2013) as well as others. All of these models, in spite of successes in modeling head impact and inertial translation/rotation accelerations, still need improvements in anatomical geometry, physics, and numerics, e.g., high strain rate material properties, modeling the CSF flows, accounting for the presence of vasculature, adequately model the micro-scale injuries, addressing numerical stiffness, and long computing times.…”

Section: Multiscale Multi-discipline Modeling Of Blast Tbimentioning

confidence: 99%

Mathematical Models of Blast-Induced TBI: Current Status, Challenges, and Prospects

Gupta¹,

Przekwas²

2013

Front. Neurol.

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Blast-induced traumatic brain injury (TBI) has become a signature wound of recent military activities and is the leading cause of death and long-term disability among U.S. soldiers. The current limited understanding of brain injury mechanisms impedes the development of protection, diagnostic, and treatment strategies. We believe mathematical models of blast wave brain injury biomechanics and neurobiology, complemented with in vitro and in vivo experimental studies, will enable a better understanding of injury mechanisms and accelerate the development of both protective and treatment strategies. The goal of this paper is to review the current state of the art in mathematical and computational modeling of blast-induced TBI, identify research gaps, and recommend future developments. A brief overview of blast wave physics, injury biomechanics, and the neurobiology of brain injury is used as a foundation for a more detailed discussion of multiscale mathematical models of primary biomechanics and secondary injury and repair mechanisms. The paper also presents a discussion of model development strategies, experimental approaches to generate benchmark data for model validation, and potential applications of the model for prevention and protection against blast wave TBI.

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Section: Multiscale Multi-discipline Modeling Of Blast Tbimentioning

confidence: 99%

Mathematical Models of Blast-Induced TBI: Current Status, Challenges, and Prospects

Gupta¹,

Przekwas²

2013

Front. Neurol.

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“…A wide range of neuromuscular neck models has been presented in the literature, ranging from 1-pivot models (44)(45)(46) to detailed multisegment models (47)(48)(49)(50)(51)(52)(53)(54)(55) and partial finite element models (56)(57)(58)(59)(60)(61)(62)(63)(64)(65). These models were primarily designed for high-severity road accident loading and/or captured only few motion directions.…”

Section: Biomechanical Head-neck Modelmentioning

confidence: 99%

Neck stabilization through sensory integration of vestibular and visual motion cues

Happee,

Kotian,

De Winkel

2023

Front. Neurol.

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BackgroundTo counteract gravity, trunk motion, and other perturbations, the human head–neck system requires continuous muscular stabilization. In this study, we combine a musculoskeletal neck model with models of sensory integration (SI) to unravel the role of vestibular, visual, and muscle sensory cues in head–neck stabilization and relate SI conflicts and postural instability to motion sickness.MethodA 3D multisegment neck model with 258 Hill-type muscle elements was extended with postural stabilization using SI of vestibular (semicircular and otolith) and visual (rotation rate, verticality, and yaw) cues using the multisensory observer model (MSOM) and the subjective vertical conflict model (SVC). Dynamic head–neck stabilization was studied using empirical datasets, including 6D trunk perturbations and a 4 m/s2 slalom drive inducing motion sickness.ResultsRecorded head translation and rotation are well matched when using all feedback loops with MSOM or SVC or assuming perfect perception. A basic version of the model, including muscle, but omitting vestibular and visual perception, shows that muscular feedback can stabilize the neck in all conditions. However, this model predicts excessive head rotations in conditions with trunk rotation and in the slalom. Adding feedback of head rotational velocity sensed by the semicircular canals effectively reduces head rotations at mid-frequencies. Realistic head rotations at low frequencies are obtained by adding vestibular and visual feedback of head rotation based on the MSOM or SVC model or assuming perfect perception. The MSOM with full vision well captures all conditions, whereas the MSOM excluding vision well captures all conditions without vision. The SVC provides two estimates of verticality, with a vestibular estimate SVCvest, which is highly effective in controlling head verticality, and an integrated vestibular/visual estimate SVCint which can complement SVCvest in conditions with vision. As expected, in the sickening drive, SI models imprecisely estimate verticality, resulting in sensory conflict and postural instability.ConclusionThe results support the validity of SI models in postural stabilization, where both MSOM and SVC provide credible results. The results in the sickening drive show imprecise sensory integration to enlarge head motion. This uniquely links the sensory conflict theory and the postural instability theory in motion sickness causation.

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“…Advanced 3D FEM models of head/brain anatomy and biomechanics and injury have been pioneered at the Wayne State university resulted in the well-known WSuBIM (Wayne State university Brain Injury Model) FEM human head model 43 . Other teams have added various refinements including the improved resolution of the neck, subarachnoid CSF, bridging veins and other anatomical feature [9][10][44][45][46] . In the last few years, FEM head/brain biomechanics models have been adapted for modelling the blast TBI by incorporating head/face anatomical details and by coupling them to the blast physics CFD solvers 7,39,[47][48][49] .…”

Section: Discussionmentioning

confidence: 99%

Multiscale Modelling of Blast-Induced TBI Mechanobiology - From Body to Neuron to Molecule

et al. 2017

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Blast induced traumatic brain injury (bTBI) has become a signature wound of the recent military operations and is becoming a significant factor of recent civilian blast explosion events. In spite of significant clinical and preclinical research on TBI, current understanding of injury mechanisms is limited and little is known about the short-term and long-term outcomes. Mathematical models of bTBI may provide capabilities to study brain injury mechanisms, perhaps accelerate the development of neuroprotective strategies and aid in the development of improved personal protective equipment. The paper presents a novel multiscale simulation framework that couples the body/brain scale biomechanics with micro-scale mechanobiology to study the effects of 'primary' micro-damage to neuro-axonal structures with the 'secondary' injury and repair mechanisms. Our results show that oligodendrocyte myelinating processes distribute strains among neighbour axons and cause their off-axis deformations. Similar effects have been observed at the finer scale for the Tau-Microtubule interaction. The need for coupled modelling of primary injury biomechanics, secondary injury mechanobiology and model based assessment of injury severity scores is discussed. A novel integrated computational and experimental approach is described coupling micro-scale injury criteria for the primary micro-mechanical damage to brain tissue/cells as well as to investigate various secondary injury mechanisms.

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Development and validation of a coupled head-neck FEM – application to whiplash injury criteria investigation

Cited by 17 publications

References 34 publications

Mathematical Models of Blast-Induced TBI: Current Status, Challenges, and Prospects

Mathematical Models of Blast-Induced TBI: Current Status, Challenges, and Prospects

Neck stabilization through sensory integration of vestibular and visual motion cues

Multiscale Modelling of Blast-Induced TBI Mechanobiology - From Body to Neuron to Molecule

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