Development and Validation of a High Performance Liquid Chromatographic Method for the Determination of Voriconazole Content in Tablets

Adams, Andréa Inês Horn; Bergold, Ana María

doi:10.1365/s10337-005-0629-1

Cited by 18 publications

(19 citation statements)

References 10 publications

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“…18,19 Practicing pharmacists should exercise caution when preparing extemporaneous voriconazole preparations that may result in the final products having an alkaline pH.…”

Section: Discussionmentioning

confidence: 99%

Stability of extemporaneously prepared voriconazole ophthalmic solution

Al‐Badriyeh¹,

Li²,

Stewart³

et al. 2009

American Journal of Health-System Pharmacy

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“…18,19 Practicing pharmacists should exercise caution when preparing extemporaneous voriconazole preparations that may result in the final products having an alkaline pH.…”

Section: Discussionmentioning

confidence: 99%

Stability of extemporaneously prepared voriconazole ophthalmic solution

Al‐Badriyeh¹,

Li²,

Stewart³

et al. 2009

American Journal of Health-System Pharmacy

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“…[25][26][27] The HPLC system consisted of a Waters 717 Plus autosampler, a Waters 1515 Isocratic HPLC pump (Waters Corporation, Milford, MA, USA), and a Gilson 117 UV-Visible detector (Gilson, Middleton, WI, USA). Separation was achieved with a Zorbax 300 SB, C8 Stable Bond, 5-lm, 150-mm 3 4.6-mm chromatographic column (Agilent Technologies, Santa Clara, CA, USA), protected by a Zorbax SB C8, 5-lm, 12.5-mm 3 4.6-mm guard cartridge (Agilent).…”

Section: Sample Analysismentioning

confidence: 99%

Voriconazole Disposition After Single and Multiple, Oral Doses in Healthy, Adult Red-tailed Hawks (Buteo jamaicensis)

Gentry¹,

Montgerard²,

Crandall³

et al. 2014

Journal of Avian Medicine and Surgery

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“…Voriconazole is commercially available in two strengths, 50 mg and 200 mg, with the brand name VFend (Pfizer, Inc.). So far, some liquid chromatographic procedures have been described for the determination of Voriconazole in tablet dosage form [1–4, 9, 10]. The HPLC method is used for the quantification of Voriconazole in plasma [5].…”

Section: Introductionmentioning

confidence: 99%

A Validated Stability-Indicating Liquid Chromatographic Method for Determination of Degradation Impurities and Diastereomers in Voriconazole Tablets

Shaikh

Patil²

2012

Sci. Pharm.

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A reversed-phase gradient liquid chromatographic method has been developed for the quantitative determination of Voriconazole, along with its degradation and diastereomeric impurities in tablet dosage form. Chromatographic separation has been achieved on an Inertsil ODS 3V, 150 × 4.6 mm, 5 μm column. The mobile phase consisting of solvent A 0.05 molar (M) potassium dihydrogen phosphate (pH 2.5 buffer) and solvent B (mixture of acetonitrile and methanol in the ratio 90:10 (v/v)), was delivered at a flow rate of 1.2 mL min−1 with the detection wavelength at 256 nm. Resolution of Voriconazole and all five potential impurities was achieved at greater than 2.0 for all pairs of compounds. The drug was subjected to stress conditions such as oxidative, acid and base hydrolysis, and thermal and photolytic degradation. Voriconazole was found to degrade significantly under base hydrolysis stress conditions compared to acid hydrolysis stress conditions. The degradation products were well-resolved from the main peak and its impurities, thus proving the stability-indicating power of the method. The stressed samples were assayed against a reference standard and the mass balance was found to be close to 99.0%. The developed method was validated as per ICH guidelines with respect to specificity, linearity, limit of detection, limit of quantification, accuracy, precision, and robustness.

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Development and Validation of a High Performance Liquid Chromatographic Method for the Determination of Voriconazole Content in Tablets

Cited by 18 publications

References 10 publications

Stability of extemporaneously prepared voriconazole ophthalmic solution

Stability of extemporaneously prepared voriconazole ophthalmic solution

Voriconazole Disposition After Single and Multiple, Oral Doses in Healthy, Adult Red-tailed Hawks (Buteo jamaicensis)

A Validated Stability-Indicating Liquid Chromatographic Method for Determination of Degradation Impurities and Diastereomers in Voriconazole Tablets

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