Development and validation of a prediction model for histologic progression in patients with nondysplastic Barrett's esophagus

Abstract

ObjectivesPatients with Barrett's esophagus (BE) are at risk of progression to esophageal adenocarcinoma (EAC). We developed a model to predict histologic progression in patients with nondysplastic BE (NDBE).MethodsA longitudinal study in three referral centers was performed between January 2010 and December 2019. As progression to low‐grade dysplasia (LGD) can be considered an indication for ablative therapy, the study end‐point was histopathologic progression to LGD, high‐grade dysplasia, or EAC at 3 years after diagnosis. We used logistic regression to create the model. Seventy percent of the cohort were used to stem the model and the remaining 30% for internal validation.ResultsA total of 542 patients were included, 69.4% of whom were male, mean age 62.2 years. Long‐segment BE at index endoscopy was diagnosed in 20.8% of the patients. After a mean follow‐up of 6.7 years, 133 patients (24.5%) had histologic progression. Our model identified a neutrophil‐to‐lymphocyte ratio (odds ratio [OR] 2.08, 95% confidence interval [CI] 1.77–2.32, P < 0.001), BE length (OR 1.22, 95% CI 1.09–1.36, P < 0.001), age (OR 1.03, 95% CI 1.02–1.05, P = 0.02), smoking (OR 1.66, 95% CI 1.09–2.75, P = 0.04), and renal failure (OR 1.51, 95% CI 0.93–2.43, P = 0.07) as predictors of histologic progression at 3 years. The areas under the receiver operating characteristic curves of this model were 0.88 and 0.76 in the training and validation cohorts, respectively.ConclusionThis novel, internally validated model may predict histologic progression, even in patients with NDBE who generally have low rates of progression over time, and may contribute to enhanced patient selection for more intense surveillance programs.

Predicting the risk of developing low‐grade dysplasia in patients with Barrett's esophagus without dysplasia

“…Peleg et al 1 . constructed a novel model to predict the risk of histological progression, including into low‐grade dysplasia (LGD), in patients with Barrett's esophagus (BE) without dysplasia.…”