Development and validation of a contouring guideline for the taste bud bearing tongue mucosa

Stieb, Sonja; Mohamed, A.S.R.; He, Renjie; Zhu, Lin; McDonald, Brigid A.; Wahid, Kareem A.; Dijk, Lisanne V. van; Ventura, Juan Irure; Ahmed, Sara; McCoy, Lance; Deshpande, T.S.; Grant, Stephen R.; Reddy, Jay P.; Phan, Jack; Garden, Adam S.; Rosenthal, D.I.; Frank, Steven J.; Gunn, G. Brandon; Fuller, Clifton D.

doi:10.1016/j.radonc.2020.11.012

Cited by 5 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Through different specific receptors, taste buds can detect five taste qualities: bitter, salt, sweet, sour, and umami (savory) 4 – 6 . Dysgeusia is common in patients undergoing head and neck radiotherapy 7 – 9 . Some patients may recover from taste dysfunction after some months or years, but a small minority of patients may suffer from permanent taste loss 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

METTL3-mediated m6A RNA methylation regulates dorsal lingual epithelium homeostasis

et al. 2022

View full text Add to dashboard Cite

The dorsal lingual epithelium, which is composed of taste buds and keratinocytes differentiated from K14+ basal cells, discriminates taste compounds and maintains the epithelial barrier. N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotic cells. How METTL3-mediated m6A modification regulates K14+ basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear. Here we show knockout of Mettl3 in K14+ cells reduced the taste buds and enhanced keratinocytes. Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds. Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization, but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery. Mechanically, we revealed that the most frequent m6A modifications were enriched in Hippo and Wnt signaling, and specific peaks were observed near the stop codons of Lats1 and FZD7. Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation.

show abstract

Section: Introductionmentioning

confidence: 99%

METTL3-mediated m6A RNA methylation regulates dorsal lingual epithelium homeostasis

et al. 2022

View full text Add to dashboard Cite

show abstract

Impact of radiation dose on patient-reported acute taste alteration in a prospective observational study cohort in head and neck squamous cell cancer (HNSCC)

Morelli,

Desideri,

Romei

et al. 2023

Radiol med

View full text Add to dashboard Cite

Purpose Taste alteration (TA) is a frequent acute side effect of radiation treatment in HNSCC patients. Principal aim of our study was to investigate dosimetric parameters in relation to patient-assessed taste impairment in a prospective cohort treated with intensity-modulated radiotherapy. Methods All patients with locally advanced HNSCC and amenable to radical treatment were included. Chemotherapy-induced taste alteration scale (CITAS), EORTC QLQ-C30 and QLQ-HN43 questionnaires at baseline (T0), 3 weeks (T1) and 3 months (T2) after radiotherapy conclusion were used to assess taste impairment. Base of tongue, submandibular glands (SG), parotid glands (PG) and taste buds, along with anterior and medium third of the tongue, were considered as organs at risk and thus delineated according to consensus guidelines. The mean dose to the above-mentioned structures was correlated with patient-reported outcomes. Results Between September 2019 and November 2020, 33 patients were recruited, 31 of which analyzed. 71% had oropharyngeal carcinoma, mostly HPV-related (60%). All were treated with tomotherapy. 77.4% had concurrent cisplatin. Mean scores of general taste alterations, global health status and dry mouth and sticky saliva were assessed. The mean doses to the anterior third, medium third and base of the tongue were 23.85, 35.50 and 47.67 Gy, respectively. Taste buds received 32.72 Gy; right and left parotid 25 and 23 Gy; right and left submandibular glands 47.8 and 39.4 Gy. At univariate analysis, dysgeusia correlated with SG mean dose (95% CI 0–0.02 p = 0.05) and PG mean dose (95% CI 0–0.02 p = 0.05); dry mouth with mean dose to anterior (95% CI 0.03–1.47 p = 0.04) and medium third (95% CI 0.02–0.93 p = 0.04) of the tongue, to taste buds (95% CI 0.06–0.96 p = 0.03) and to SGs (95% CI 0.06–0.63 p = 0.02); pain mouth with mean dose to taste buds (95% CI 0–0.02 p = 0.04), to SGs (95% CI 0–0.03 p = 0.03) and to base tongue (95% CI 0–0.02 p = 0.02). Conclusions Our analysis supports the influence of dose distribution on the development of TA in HNSCC patients. The contribution of dose to taste buds and tongue subvolumes remains unclear and worthy of further investigation.

show abstract

Assessing Interobserver Variability in the Delineation of Structures in Radiation Oncology: A Systematic Review

Guzene

Beddok

Nioche

et al. 2023

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

Development and validation of a contouring guideline for the taste bud bearing tongue mucosa

Cited by 5 publications

References 17 publications

METTL3-mediated m6A RNA methylation regulates dorsal lingual epithelium homeostasis

METTL3-mediated m6A RNA methylation regulates dorsal lingual epithelium homeostasis

Impact of radiation dose on patient-reported acute taste alteration in a prospective observational study cohort in head and neck squamous cell cancer (HNSCC)

Assessing Interobserver Variability in the Delineation of Structures in Radiation Oncology: A Systematic Review

Contact Info

Product

Resources

About