Development and Validation of a Quantitative Gas Chromatography ? Mass Spectrometry Confirmatory Method for Phenylbutazone in Equine Plasma

Doping Control Analysis of 16 Non-Steroidal Anti-Inflammatory Drugs in Equine Plasma Using Liquid Chromatography-Tandem Mass Spectrometry

“…A number of methods have been developed for detecting a single or a group of NSAIDs in human and animal biological matrices using high performance liquid chromatography (HPLC) [10]- [15], capillary electrophoresis [16], gas chromatography-mass spectrometry [17]- [19] and liquid chromatography-mass spectrometry [20]- [24]. These methods focused mainly on quantification of one or a few NSAIDs in biological matrices but were not for anti-doping control analysis, for which the method should be able to detect as many drug suspects as possible during screening and provide unequivocal evidence to demonstrate confirmation of the analyte.…”

Analytical strategy for the confirmatory analysis of the non-steroidal anti-inflammatory drugs firocoxib, propyphenazone, ramifenazone and piroxicam in bovine plasma by liquid chromatography tandem mass spectrometry

“…Methods have been reported for the analysis of NSAIDs in plasma in the literature by LC-UV [15,16,[18][19][20][21][22][23][24], GC-MS [19,[25][26][27][28], LC-MS [17,23,25,[29][30][31] and capillary electrophoresis [32]. The majority of methods that have been cited to date have been developed in equine plasma or serum alone or in combination with other matrices [17][18][19][20]22,[25][26][27][30][31][32] with limits of detection ranging from 0.1 ng ml −1 to 5 g ml −1 . Other methods exist for the determination of NSAIDs in bovine plasma or serum but the limits of detection range from 20 ng to 3.4 g ml −1 [15,21,22,24,29,30] or in rat serum [23].…”