Development and use of a gastropathy index for ranking the safety of non-steroidal anti-inflammatory drugs in the elderly

Trewin, V. F.; Lawrence, C. J.; Rae, S.; Veitch, G. B. A.

doi:10.1111/j.1365-2710.1994.tb00675.x

Cited by 10 publications

(3 citation statements)

References 21 publications

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“…Diclofenac and ibuprofen are the most commonly prescribed anti-inflammatory drugs, both of which have a good safety record (Langman et al, 1994), whereas ketoprofen (trade name Oruvail) is not commonly prescribed, perhaps because it carries a higher risk of gastro-intestinal side-effects (Trewin et al, 1994). This is reflected in the different levels of recognition of these drugs.…”

Section: Names Of Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Evaluation of information given to rheumatology patients using non-steroidal anti-inflammatory drugs

Arthur

Clifford

1998

J Clin Nurs

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This paper reports the findings of a study of information given to rheumatology patients using non-steroidal anti-inflammatory drugs. One hundred and twenty patients were randomized to three groups. Group A received an information leaflet, Group B received both a leaflet and a verbal explanation and Group C received only a verbal explanation. Information was gathered on demography, knowledge base, sources of information, satisfaction with the leaflet and further information requirements. Data were collected by questionnaires which were completed before randomization and 8-12 weeks later. Analysis indicates the potential benefits of giving information to patients although the full implications of these benefits are not clear and further research is indicated in this important area.

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Section: Names Of Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Evaluation of information given to rheumatology patients using non-steroidal anti-inflammatory drugs

Arthur

Clifford

1998

J Clin Nurs

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“…Celecoxib, Rofecoxib, 69 Drug with low gut toxicity, e.g. Ibuprofen, Diclofenac, 70 , 71 Drug with intermediate toxicity, e.g. Ketoprofen, Flurbiprofen, 71 Drug with very high toxicity, e.g.…”

Section: Resultsmentioning

confidence: 99%

Pain management in trauma: A review study

2016

J Inj Violence Res

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Abstract:Background:Pain in trauma has a role similar to the double-edged sword. On the one hand, pain is a good indicator to determine the severity and type of injury. On the other hand, pain can induce sever complications and it may lead to further deterioration of the patient. Therefore, knowing how to manage pain in trauma patients is an important part of systemic approach in trauma. The aim of this manuscript is to provide information about pain management in trauma in the Emergency Room settings.Methods:In this review we searched among electronic and manual documents covering a 15-yr period between 2000 and 2016. Our electronic search included Pub Med, Google scholar, Web of Science, and Cochrane databases. We looked for articles in English and in peer-reviewed journals using the following keywords: acute pain management, trauma, emergency room and injury. Results:More than 3200 documents were identified. After screening based on the study inclusion criteria, 560 studies that had direct linkage to the study aim were considered for evaluation based World Health Organization (WHO) pain ladder chart. Conclusions:To provide adequate pain management in trauma patients require: adequate assessment of age-specific pharmacologic pain management; identification of adequate analgesic to relieve moderate to severe pain; cognizance of serious adverse effects of pain medications and weighting medications against their benefits, and regularly reassessing patients and reevaluating their pain management regimen. Patient-centered trauma care will also require having knowledge of barriers to pain management and discussing them with the patient and his/her family to identify solutions.

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“…For example, comparative studies have almost invariably reported that ibuprofen is one of the safest NSAIDs. 12,16,31,32 A recent study has shed light on why this occurs, and points out one of the fallacies of doing comparative studies without knowing why a particular drug was chosen. For example, ibuprofen was most likely to be given to patients with mild disease requiring intermittent therapy, whereas patients with serious inflammatory conditions were much more likely to receive a drug with high COX-1 activity such as piroxicam.…”

Section: Causes Of Peptic Ulcermentioning

confidence: 99%

NSAID ulcers: prevalence and prevention

Graham¹

2000

Modern Rheumatology

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The epidemic of life-threatening complications of nonsteroidal anti-inflammatory drug (NSAID) use has prompted the development of prevention strategies. Recent clinical trials of endoscopic ulcer prevention are critiqued regarding their results in relation to doses and outcome measures as well as H. pylori status. Misoprostol is the only agent proven to prevent life-threatening ulcer complication in NSAID users. Proton pump inhibitor therapy was not significantly better than the minimally effective dose of misoprostol for prevention of gastroduodenal ulcers in chronic NSAID users, and was significantly inferior to misoprostol in those with "true" NSAID ulcers (i.e., without complicating H. pylori infection). Antisecretory therapy accelerates corpus gastritis in those with H. pylori infection, suggesting it is prudent to consider H. pylori eradication in those in whom long term co-therapy with anti-secretory therapy is contemplated. H. pylori status is a critical variable with regard to endoscopic ulcers in NSAID users. The data suggest that if full-dose misoprostol cannot be given, the combination of an antisecretory drug (e.g., either ranitidine or omeprazole) plus low-dose misoprostol may be better than either alone for the prevention of NSAID ulcer complications. The use of omeprazole alone likely results in a false sense of security.

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Development and use of a gastropathy index for ranking the safety of non-steroidal anti-inflammatory drugs in the elderly

Cited by 10 publications

References 21 publications

Evaluation of information given to rheumatology patients using non-steroidal anti-inflammatory drugs

Evaluation of information given to rheumatology patients using non-steroidal anti-inflammatory drugs

Pain management in trauma: A review study

NSAID ulcers: prevalence and prevention

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