Development and usability of a web-based patient-tailored tool to support adherence to urate-lowering therapy in gout

Kampe, Ritch Te; Boonen, Annelies; Jansen, Tim L.; Elling, Jan Mathis; Flendrie, Marcel; Eijk-Hustings, Yvonne van; Janssen, Matthijs; Durme, Caroline van; Vries, Hein de

doi:10.1186/s12911-022-01833-6

Cited by 3 publications

(3 citation statements)

References 60 publications

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“…Second, the content and time allocated to therapeutic information and education were not reported in patients' medical les and could not be measured directly in our study, while its importance is emphasized by the latest recommendations (3,13) and some recent works such as those of Te Kampe et al (25).…”

Section: Discussionmentioning

confidence: 83%

Simple application of gout guidelines enables disease control: an observational study in French referral centres

Jauffret

Ottaviani

Latourte

et al. 2022

Preprint

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BackgroundRecent studies have shown a lack of implementation of gout recommendations in primary care. In this context of therapeutic inertia, the French Society of Rheumatology (SFR) published its first recommendations on gout in 2020, which were deliberately simple and concise. ObjectivesThe objectives were to determine the profile of patients referred to French gout expert centres, and to examine the results of their management and the factors leading to those results. MethodsThree hundred patients attending a first visit for gout management in three French referral centres were retrospectively and randomly included in this multicentre observational study.Visits were performed at baseline (M0) and scheduled for month 6 (M6), month 12 (M12), and month 24 (M24). Data collected included: patient profile; disease activity and treatments; serum urate (SU) level; estimated glomerular filtration rate (eGFR). ResultsPatients were 81% male and mean age 62.2 ± 15.2 years. Only 15,3% of them had difficult-to-treat gout at baseline. Management followed French recommendations after the baseline visit in 94.9% of cases. SU levels were below 6.0mg/dL in 59.4% of patients at M6, 67.9% at M12, and 78.6% at M24, with increasing clinical improvement (i.e. flare decrease) over 2 years of follow-up. At M24, 50% of patients were treated with allopurinol (313 ± 105 mg/d), which exceeded renal restrictions of doses in 61.5% of them, and 48.2% received febuxostat (84 ± 36mg/d). The need for a sufficient dosage of ULT was the only predictive factor found for successful reach SU levels <6.0mg/dL at a given visit. Overall, 50 patients (16.7%) received off-label anakinra for flare treatment or flare prophylaxis. ConclusionSimple application of gout management guidelines is feasible in clinical practice, and is efficient with a majority of patients achieving SU targets and clinical improvement.

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Section: Discussionmentioning

confidence: 83%

Simple application of gout guidelines enables disease control: an observational study in French referral centres

Jauffret

Ottaviani

Latourte

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Second, the content and time allocated to therapeutic information and education were not reported in patients’ medical files and could not be measured directly in our study, although their importance is emphasized by the latest recommendations [ 3 , 13 ] and some recent works such as those by Te Kampe et al [ 26 ].…”

Section: Discussionmentioning

confidence: 98%

Simple Application and Adherence to Gout Guidelines Enables Disease Control: An Observational Study in French Referral Centres

Jauffret

Ottaviani²,

Latourte

et al. 2022

JCM

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Background: In a context of therapeutic inertia, the French Society of Rheumatology (SFR) published its first recommendations on gout in 2020, which were deliberately simple and concise. The objectives of the study were to determine the profile of patients referred to French gout-expert centres, and to examine the results of their management and the factors leading to those results. Methods: Three hundred patients attending a first visit for gout management in three French referral centres were retrospectively and randomly included in this multicentre observational study. Visits were performed at baseline (M0) and scheduled for month 6 (M6), month 12 (M12), and month 24 (M24). Results: Patients were 81% male and had a mean age 62.2 ± 15.2 years. Management followed French recommendations after the baseline visit in 94.9% of cases. SU levels were below 6.0 mg/dL in 59.4% of patients at M6, 67.9% at M12, and 78.6% at M24, with increasing clinical improvement (i.e., flare decrease) over 2 years of follow-up. At M24, 50% of patients were treated with allopurinol (313 ± 105 mg/d), which exceeded renal restrictions of doses in 61.5% of them, and 48.2% received febuxostat (84 ± 36 mg/d). The need for a sufficient dosage of ULT was the only predictive factor found for successful achievement of SU levels < 6.0 mg/dL at a given visit. Conclusions: Simple application of gout-management guidelines is feasible in clinical practice and is efficient, with a majority of patients achieving SU targets and clinical improvement.

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“…These findings are in line with previous studies, emphasizing the importance of patient education on the chronic nature of gout and the importance of consistent adherence to prevent future attacks and long-term complications [ 20 ]. By fostering a comprehensive understanding of gout as a chronic condition and elucidating the benefits of sustained medication use, websites can foster informed decision-making among patients and promote a long-term commitment to therapy [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

A content analysis of medication adherence material in patient educational resources about gout

Emad,

Derksen,

Petrie

et al. 2024

Rheumatology Advances in Practice

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Objective This study aimed to investigate how medication adherence is addressed in online gout resources in six countries. We investigated how often adherence was referred to, the strategies suggested to improve patient adherence, and the types of nonadherence that were targeted. We also examined the readability of the adherence material. Methods A content analysis was conducted on 151 online gout resources from medical and health organisations in six predominantly English-speaking countries. Two reviewers coded the content of the websites into categories (kappa 0.80). The analysis involved coding the resources for reasons for nonadherence, and adherence-promoting strategies. Flesch-Kincaid Reading Ease scores and word count were also computed. Results Out of 151 websites examined, 77 websites discussed medication adherence (51%), with intentional nonadherence being more prevalent than unintentional nonadherence. 67 websites targeted different types of nonadherence, included drug-specific concerns (50%), misconceptions of gout curability and the necessity of medication (16%), forgetfulness (16%), and other practical challenges (5%). Strategies to promote adherence were found in one-third of the websites, with medication education being the most prevalent strategy (17%), followed by healthcare provider engagement (13%) and memory aid strategies (6%). On average, about 11% of the words (89.27, SD = 76.35) in the entire document were focused on adherence. Difficult reading comprehension was found in one-fifth of adherence-related websites. Conclusion Findings reveal limited medication adherence coverage and narrow strategies in online gout resources. Improved adherence portrayal is needed for effective gout management through comprehensive strategies and clear, understandable information.

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Development and usability of a web-based patient-tailored tool to support adherence to urate-lowering therapy in gout

Cited by 3 publications

References 60 publications

Simple application of gout guidelines enables disease control: an observational study in French referral centres

Simple application of gout guidelines enables disease control: an observational study in French referral centres

Simple Application and Adherence to Gout Guidelines Enables Disease Control: An Observational Study in French Referral Centres

A content analysis of medication adherence material in patient educational resources about gout

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