Development and thermochemical characterization of an antioxidant material based on polyhydroxybutyrate electrospun microfibers

Vilchez, Ariel; Acevedo, Francisca; Cea, Mara; Seeger, Michael; Navia, Rodrigo

doi:10.1016/j.ijbiomac.2021.05.002

Cited by 11 publications

(2 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By FTIR analysis, polyphenols usually have a stretching band corresponding to the hydroxyl group (at 3400 cm −1 ). The analysis of PHB-quercetin microfibers suggested interactions as hydrogen bonds between the antioxidant groups and the carbonyl groups of PHB that can prevent the stretching vibrations of the hydroxyl group [46]. Other studies concentrated on the integration of components from Ginkgo biloba extract (bilobalide, ginkgolides A, B, and C) into mPEG-PLGA-mPEG (PELGE)-based, extended-release nanosystems for parenteral administration [47].…”

Section: Discussionmentioning

confidence: 99%

Preparation and Preliminary Analysis of Several Nanoformulations Based on Plant Extracts and Biodegradable Polymers as a Possible Application for Chronic Venous Disease Therapy

Ungureanu,

Ozon,

Musuc

et al. 2024

Polymers

View full text Add to dashboard Cite

Nanotechnology is one of the newest directions for plant-based therapies. Chronic venous disease often predisposes to long-term and invasive treatment. This research focused on the inclusion of vegetal extracts from Sophorae flos (SE), Calendulae flos (CE), and Ginkgo bilobae folium (GE) in formulations with PHB and PLGA polymers and their physicochemical characterization as a preliminary stage for possible use in the development of a complex therapeutic product. The samples were prepared by an oil–water emulsification and solvent evaporation technique, resulting in suspensions with high spreadability and a pH of 5.5. ATR-FTIR analysis revealed bands for stretching vibrations (O-H, C=O, and C-H in symmetric and asymmetric methyl and methylene) in the same regions as the base components, but switched to high or low wavenumbers and absorbance, highlighting the formation of adducts/complexes between the extracts and polymers. The obtained formulations were in the amorphous phase, as confirmed by XRD analysis. AFM analysis emphasized the morphological peculiarities of the extract–polymer nanoformulations. It could be noticed that, in the case of SE-based formulations, the dominant characteristics for SE-PHB and SE-PLGA composition were the formation of random large (SE-PHB) and smaller uniform (SE-PLGA) particles; further on, these particles tended to aggregate in the case of SE-PHB-PLGA. For the CE- and GE-based formulations, the dominant surface morphology was their porosity, generally with small pores, but larger cavities were observed in some cases (CE- and GE-PHB). The highest roughness values at the (8 µm × 8 μm) scale were found for the following samples and succession: CE-PHB < SE-PLGA < SE-PHB-PLGA. In addition, by thermogravimetric analysis, impregnation in the matrix of compression stockings was evaluated, which varied in the following order: CE-polymer > SE-polymer > GE-polymer. In conclusion, nine vegetal extract–polymer nanoformulations were prepared and preliminarily characterized (by advanced physicochemical methods) as a starting point for further optimization, stability studies, and possible use in complex pharmaceutical products.

show abstract

Section: Discussionmentioning

confidence: 99%

Preparation and Preliminary Analysis of Several Nanoformulations Based on Plant Extracts and Biodegradable Polymers as a Possible Application for Chronic Venous Disease Therapy

Ungureanu,

Ozon,

Musuc

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

“…The first heating process has the objective to erase the thermal history of the polymer matrix and remove moisture because water acts as a plasticizer and modifies the properties of the polymers, and the second cycle identifies melting and crystallinity temperature, and, in some cases, the generation of crystals of different sizes [ 92 , 93 ]. Thermogravimetric analysis (TGA) measures the mass variation when the temperature changes [ 94 , 95 ].…”

Section: Pha–vegetal Fiber Compositesmentioning

confidence: 99%

Biopackaging Potential Alternatives: Bioplastic Composites of Polyhydroxyalkanoates and Vegetal Fibers

et al. 2022

View full text Add to dashboard Cite

Initiatives to reduce plastic waste are currently under development worldwide. As a part of it, the European Union and private and public organizations in several countries are designing and implementing regulations for single-use plastics. For example, by 2030, plastic packaging and food containers must be reusable or recyclable. In another approach, researchers are developing biopolymers using biodegradable thermoplastics, such as polyhydroxyalkanoates (PHAs), to replace fossil derivatives. However, their production capacity, high production costs, and poor mechanical properties hinder the usability of these biopolymers. To overcome these limitations, biomaterials reinforced with natural fibers are acquiring more relevance as the world of bioplastics production is increasing. This review presents an overview of PHA–vegetal fiber composites, the effects of the fiber type, and the production method’s impact on the mechanical, thermal, barrier properties, and biodegradability, all relevant for biopackaging. To acknowledge the behaviors and trends of the biomaterials reinforcement field, we searched for granted patents focusing on bio-packaging applications and gained insight into current industry developments and contributions.

show abstract

Physico-mechanical Evaluation of Electrospun Nanofibrous Mats of Poly(3-hydroxybutyrate)/Poly(butylene succinate) Blends with Enhanced Swelling-Dynamics and Hydrolytic Degradation-Kinetics Stability for Pliable Scaffold Substrates

Peshne,

Das,

Sharma

et al. 2024

J Polym Environ

View full text Add to dashboard Cite

Development and thermochemical characterization of an antioxidant material based on polyhydroxybutyrate electrospun microfibers

Cited by 11 publications

References 59 publications

Preparation and Preliminary Analysis of Several Nanoformulations Based on Plant Extracts and Biodegradable Polymers as a Possible Application for Chronic Venous Disease Therapy

Preparation and Preliminary Analysis of Several Nanoformulations Based on Plant Extracts and Biodegradable Polymers as a Possible Application for Chronic Venous Disease Therapy

Biopackaging Potential Alternatives: Bioplastic Composites of Polyhydroxyalkanoates and Vegetal Fibers

Physico-mechanical Evaluation of Electrospun Nanofibrous Mats of Poly(3-hydroxybutyrate)/Poly(butylene succinate) Blends with Enhanced Swelling-Dynamics and Hydrolytic Degradation-Kinetics Stability for Pliable Scaffold Substrates

Contact Info

Product

Resources

About