Development and testing of hyperpolarized 13C MR calibrationless parallel imaging

Feng, Yesu; Gordon, Jeremy W.; Shin, Peter; Morze, Cornelius von; Lustig, Michael; Larson, Peder E. Z.; Ohliger, Michael A.; Carvajal, Lucas; Tropp, James; Pauly, John M.; Vigneron, Daniel B.

doi:10.1016/j.jmr.2015.10.018

Cited by 19 publications

(28 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A variable flip angle scheme can be implemented for each desired metabolite using a non-convex optimization approach that would increase SNR, reduce image blurring, and improve off-resonance insensitivity for single time-point images, or maximize SNR for high resolution dynamic imaging [81]. The bSSFP sequence and these specific acquisition and reconstruction approaches can also be readily combined with parallel imaging [82,83], which may be required as the translation from preclinical to clinical imaging will require larger matrix sizes for the same desired isotropic resolution.…”

Section: Discussionmentioning

confidence: 99%

Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques

Milshteyn

Morze

Reed

et al. 2017

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

The goal of this project was to develop and apply techniques for T2 mapping and 3D high resolution (1.5 mm isotropic; 0.003 cm3) 13C imaging of hyperpolarized (HP) probes [1-13C]lactate, [1-13C]pyruvate, [2-13C]pyruvate, and [13C,15N2]urea in vivo. A specialized 2D bSSFP sequence was implemented on a clinical 3T scanner and used to obtain the first high resolution T2 maps of these different hyperpolarized compounds in both rats and tumor-bearing mice. These maps were first used to optimize timings for highest SNR for single time-point 3D bSSFP acquisitions with a 1.5 mm isotropic spatial resolution of normal rats. This 3D acquisition approach was extended to serial dynamic imaging with 2-fold compressed sensing acceleration without changing spatial resolution. The T2 mapping experiments yielded measurements of T2 values of greater than 1 s for all compounds within rat kidneys/vasculature and TRAMP tumors, except for [2-13C]pyruvate which was ~730 ms and ~320 ms, respectively. The high resolution 3D imaging enabled visualization the biodistribution of [1-13C]lactate, [1-13C]pyruvate, and [2-13C]pyruvate within different kidney compartments as well as in the vasculature. While the mouse anatomy is smaller, the resolution was also sufficient to image the distribution of all compounds within kidney, vasculature, and tumor. The development of the specialized 3D sequence with compressed sensing provided improved structural and functional assessments at a high (0.003 cm3) spatial and 2 s temporal resolution in vivo utilizing HP 13C substrates by exploiting their long T2 values. This 1.5 mm isotropic resolution is comparable to 1H imaging and application of this approach could be extended to future studies of uptake, metabolism, and perfusion in cancer and other disease models and may ultimately be of value for clinical imaging.

show abstract

Section: Discussionmentioning

confidence: 99%

Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques

Milshteyn

Morze

Reed

et al. 2017

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

show abstract

“…Besides the fast MRSI methods described above, other fast imaging strategies commonly used in 1 H-MRI such as parallel imaging (182)(183)(184) and compressed sensing (185) are also promising to be combined with MRSI techniques to further accelerate the acquisition. These techniques have already been applied to imaging hyperpolarized carbon-13 molecules (186,187). Compressed sensing has also been combined with spectrally selective 31 P imaging to accelerate the imaging of PCr recovery kinetics in humans (188).…”

Section: P-mrsi Methodsmentioning

confidence: 99%

Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review

Liu

2017

Quant. Imaging Med. Surg.

View full text Add to dashboard Cite

Many human diseases are caused by an imbalance between energy production and demand.Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) provide the unique opportunity for in vivo assessment of several fundamental events in tissue metabolism without the use of ionizing radiation. Of particular interest, phosphate metabolites that are involved in ATP generation and utilization can be quantified noninvasively by phosphorous-31 ( 31 P) MRS/MRI. Furthermore, 31 P magnetization transfer (MT) techniques allow in vivo measurement of metabolic fluxes via creatine kinase (CK) and ATP synthase. However, a major impediment for the clinical applications of 31 P-MRS/MRI is the prohibitively long acquisition time and/or the low spatial resolution that are necessary to achieve adequate signal-to-noise ratio. P-MRS/MRI techniques. Applications of these techniques to the investigation of a specific physiology/pathology will be discussed without detailed description. Interested readers are referred to recent review articles on the applications of 31 P-MRS/MRI in metabolic characterization of skeletal muscle (10-12), heart (13), brain (14), and liver (11), as well as in diseases such as cancer (15), heart failure (16), and obesity and diabetes (17,18). Historical perspectiveThe use of 31 P-MRS for metabolic investigations dates back to 1960. Cohn and Hughes were the first to obtain a high-resolution 31 P spectrum of a solution of ATP (19). In addition, they also observed a dependence of the chemical shifts of the phosphorus nuclei of ATP on the pH of the solution. In parallel to the early development of MRI methods by Lauterbur (20), the entire 1970s also witnessed the rapid advance of 31 P-MRS in metabolic investigation of a broad range of biological systems. In 1973, Moon and Richards performed the first 31 P-MRS study that measured intracellular pH in human red blood cells (21). In the following year, Henderson and colleagues obtained the first 31 P spectrum of ATP from human red blood cells (22). At the same time, the Oxford team led by Radda performed the first experiment to acquire 31 P spectra from an intact organ, i.e., the excised and superfused muscle of rat hindlimb (23). The first in vivo 31 P-MRS study was performed on mouse brain by Chance et al. (24). Within the short span of one decade, organelles including mitochondria (25,26) and chromaffin granules (27), cells including Escherichia coli (28), yeast (29), and hepatocytes (30), and organs including skeletal muscle (31,32), heart (33-35), brain (36), kidney (37), and liver (38,39) have all been studied using 31 P-MRS.It is worth noting that most of these organ studies were performed on excised organs to avoid the need for spatial localization. Although Lauterbur has demonstrated the feasibility of imaging water protons (20), it was considered impractical for 31 P imaging of living systems because of the low sensitivity and difficulties with spectral resolution.The 1980s began with the publication of two important studies that aimed a...

show abstract

“…Partial Fourier sampling has been previously combined with parallel imaging to reduce the acquisition time of HP

^{13} C

echo‐planar spectroscopic imaging in a preclinical study, but since the methods were coupled, the independent performance of the partial Fourier reconstruction could not be assessed. In a recent preclinical study based on 2D HP

^{13} C

EPI, the spatial resolution of partial Fourier sampling was qualitatively compared to a calibrationless parallel imaging method that utilized pseudo‐random undersampling along the blipped direction. Here, we tested whether the application of partial Fourier image reconstruction would improve spatial resolution from hyperpolarized [1‐

^{13} C

]pyruvate scans in the human brain.…”

Section: Introductionmentioning

confidence: 99%

Partial Fourier reconstruction for improved resolution in 3D hyperpolarized ¹³C EPI

Geraghty

Lee

Chen³

et al. 2019

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose Asymmetric in‐plane k‐space sampling of EPI can reduce the minimum achievable TE in hyperpolarized 13C with spectral‐spatial radio frequency pulses, thereby reducing T2* weighting and signal‐losses. Partial Fourier image reconstruction exploits the approximate Hermitian symmetry of k‐space data and can be applied to asymmetric data sets to synthesize unmeasured data. Here we tested whether the application of partial Fourier image reconstruction would improve spatial resolution from hyperpolarized [1‐13C]pyruvate scans in the human brain. Methods Fifteen healthy control subjects were imaged using a volumetric dual‐echo echo‐planar imaging sequence with spectral‐spatial radio frequency excitation. Images were reconstructed by zero‐filling as well as with the partial Fourier reconstruction algorithm projection‐on‐convex‐sets. Resulting images were quantitatively evaluated with a no‐reference image quality assessment. Results The no‐reference image sharpness metric agreed with perceived improvements in image resolution and contrast. The [1‐13C]lactate images benefitted most, followed by the [1‐13C]pyruvate images. The 13C‐bicarbonate images were improved by the smallest degree, likely owing to relatively lower SNR. Conclusions Partial Fourier imaging and reconstruction were shown to improve the sharpness and contrast of human HP 13Cbrain data and is a viable method for enhancing resolution.

show abstract

Development and testing of hyperpolarized 13C MR calibrationless parallel imaging

Cited by 19 publications

References 31 publications

Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques

Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques

Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review

Partial Fourier reconstruction for improved resolution in 3D hyperpolarized ¹³C EPI

Contact Info

Product

Resources

About

Development and testing of hyperpolarized 13C MR calibrationless parallel imaging

Cited by 19 publications

References 31 publications

Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques

Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques

Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review

Partial Fourier reconstruction for improved resolution in 3D hyperpolarized 13C EPI

Contact Info

Product

Resources

About

Partial Fourier reconstruction for improved resolution in 3D hyperpolarized ¹³C EPI