2017
DOI: 10.1016/j.apt.2017.03.026
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Development and tableting of directly compressible powder from electrospun nanofibrous amorphous solid dispersion

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Cited by 31 publications
(19 citation statements)
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“…Therefore, the addition of flowability aiding excipients is necessary. Interestingly, the powder mixture consisting of ASD of SPIR and PVPVA64 and the tableting excipients had much improved flowability, which is surprising considering results of similar subject in the literature [59]. (Hausner ratio: 1.12, Carr index: 11%; according to the U.S. Pharmacopeia, powder blends with Hausner ratios between 1.12 and 1.18 and Carr indices between 11 and 15% receive the second best, 'good' classification for flowability).…”
Section: Tabletingmentioning
confidence: 85%
“…Therefore, the addition of flowability aiding excipients is necessary. Interestingly, the powder mixture consisting of ASD of SPIR and PVPVA64 and the tableting excipients had much improved flowability, which is surprising considering results of similar subject in the literature [59]. (Hausner ratio: 1.12, Carr index: 11%; according to the U.S. Pharmacopeia, powder blends with Hausner ratios between 1.12 and 1.18 and Carr indices between 11 and 15% receive the second best, 'good' classification for flowability).…”
Section: Tabletingmentioning
confidence: 85%
“…Related to the downstream processing of electrospun material, tableting was successfully performed from protein-type drug-loaded [34] and from acetaminophen-loaded electrospun fibers [35]. Since then, a minitablet formulation from electrospun nanofibers has been published in the literature [36], and tableting of itraconazole containing electrospun ASDs with other excipients also was scrutinized [37]. The latter one seems to be curiously promising in the industrial application because a scaled-up electrospinning method with high productivity and a rotary tablet machine were applied during the experiments.…”
Section: Preparation Of Polymer-based Amorphous Solid Dispersionsmentioning
confidence: 99%
“…However, powder properties of the electrospun samples are fairly weak, which can make the formulation process difficult. Therefore, the milling of these products might be needed if tablet forms are planned to be achieved [37]. On the other hand, other formulation strategies such as dry coating or granulation also may be appropriate to increase the flow properties of the fiber-based powders.…”
Section: Improvement Of the Flowability Of Asds For Continuous Feedingmentioning
confidence: 99%
“…The application of this MCC subtype was preferable since ES products are hygroscopic. The adoption of both materials was desirable since (as it was described in our previous work [ 48 ]) the electrospun samples can adhere to their surfaces. Ultimately, this phenomenon sets the foundation to achieve proper homogenization.…”
Section: Resultsmentioning
confidence: 99%