Development and Rheological studies of gels with Essential oil of Chamomile (Chamomillae recutita L.)

Abstract

The article presents the results of research on the development of dosage forms with essential oil of chamomile (Chamomillae recutita L.) for dental use. The object of study was hydrophilic gel base under the code name "Chamazulenogelum". Materials and Methods. Rheological studies were carried out on a rotational viscometer Visco Star Plus (Fungilab, Spain). The study of the structural and mechanical properties of the "Chamazulenogelum" ointment was carried out at temperatures of 25, 40, 55 and 70°C. The shear stress and dynamic viscosity of the gels were measured. Based on the obtained results, graphs are constructed that characterize the change in the logarithm of the effective viscosity on the shear flow rate gradient and the dependence of the shear flow rate gradient on the shear stress. The results of rheological studies showed the absence of structural changes in the shear field with destruction or the appearance of new compounds; the thixotropic properties of the hydrophilic gel bases "Chamazulenogelum" were also established. Results and Discussion. As a result of studying the antimicrobial and antifungal activity of dosage forms with chamomile essential oil, it was found that the gels inhibit the growth of test cultures in vitro to some extent. High-intensity antimicrobial activity was shown by the hydrophilic gel "Chamazulenogelum" against Staphylococcus aureus and Escherichia coli. Conclusion: The investigated samples of "Chamazulenogelum" gels do not undergo strong structural changes in the shear field, that is, there are no intrasystem rearrangements with destruction or with the formation of new compounds. The thixotropic properties on the hydrophilic gel base "Chamazulenogelum" have been established, which characterize good smearability and the ability to extrude from the tube. The pronounced antimicrobial activity of the developed gels "Chamazulenogelum" for topical use provides a basis for further tests included in the drug development cycle.