Development and regulation of pancreatic juice
secretion in cattle. State-of-the-art

Zabielski, R.; Pierzynowski, Stefan

doi:10.22358/jafs/67939/2001

Cited by 5 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The flow rate of pancreatic juice secreted by a 4-day-old calf is only 150 mL/24 h, while a 100-day-old calf secreted over 1, 000 mL/24 h ( Mccormick and Stewart, 1967 ). It was also reported that the daily pancreatic secretion increased from 7.9 mL/kg body weight in 3-week-old calves up to 14.2 mL/kg body weight 2 months later ( Zabielski et al., 2001 ). A more substantial increase (3-fold) was also observed in the daily pancreatic protein output during that period.…”

Section: Factors Affecting the Exocrine Function Of The Pancreasmentioning

confidence: 94%

Regulation of pancreatic exocrine in ruminants and the related mechanism: The signal transduction and more

2021

View full text Add to dashboard Cite

The unique structure of the stomach, including the rumen, reticulum, omasum, and abomasum, indicates the differences between the ruminant and monogastric animals in the digestion of nutrients. This difference is reflected in the majority of dietary nutrients that may be fermented in the rumen. Significant proteins and a certain amount of starch can flow to the small intestine apart from rumen. The initial phase of small intestinal digestion requires pancreatic digestive enzymes. In theory, the enzymatic digestion and utilization efficiency of starch in the small intestine are considerably higher than that in the rumen, but the starch digestibility in the small intestine is quite low in ruminants. Therefore, improving the digestion of nutrients, especially starch in the small intestine is more urgent for high-yield ruminants. Although the pancreas plays a central role in nutrient digestion, the progress of research investigating pancreatic exocrine regulation in the ruminant is slow due to some factors, such as the complex structure of the pancreas, the selection of experimental model and duration, and internal (hormones or ages) and external (diet) influences. The present review is based on the research findings of pancreatic exocrine regulation of dairy animals and expounded from the physiological structure of the ruminant pancreas, the factors affecting the digestion and exocrine processing of carbohydrates, and the regulatory mechanism governing this process. The review aims to better understand the characteristics of enzymatic digestion, thereby advancing pancreatic exocrine research and improving the digestion and utilization of nutrients in ruminants. Additionally, this review provides the theoretical basis for improving nutrient utilization efficiency, reducing wastage of feed resources, and promoting the efficient development of the dairy industry.

show abstract

Section: Factors Affecting the Exocrine Function Of The Pancreasmentioning

confidence: 94%

Regulation of pancreatic exocrine in ruminants and the related mechanism: The signal transduction and more

2021

View full text Add to dashboard Cite

show abstract

“…These activities concern GI motility and digestive secretions, including endocrine secretions (Konturek et al, 1986;Zabielski et al, 1998). The GI motility and periodic activity of the exocrine pancreas of young ruminants have been described in detail previously (Zabielski and Naruse, 1999;Zabielski et al, 1993Zabielski et al, , 1997Zabielski et al, , 1998Zabielski et al, , 2001. In brief, the small intestine MMC consists of three distinct phases in the calf: the no spiking activity (NSA) phase, irregular spiking activity (ISA) phase, and regular spiking activity (RSA) phase (Dardillat and Ruckebush, 1973;Dardillat and Marrero, 1977;Dardillat and Bueno, 1979).…”

Section: Gut Regulatory Peptides and Digestive Motilitymentioning

confidence: 95%

Gut regulatory peptides as mediators of gastrointestinal tract growth, motility and development of secretion in young ruminants

Guilloteau

Zabielski²

2005

J. Anim. Feed Sci.

Self Cite

View full text Add to dashboard Cite

In mammalian species, the prenatal development of foetal tissues is programmed to result in the organization of different functions of the organism. During development, non-genetic factors are involved and act through regulatory substances. It is frequently said that the GIT represents "the largest endocrine organ in the body". Most of these substances depend on an intricate regulatory complex increasingly recognized as a unique system having multiple aspects, including hormonal, nervous and immune ones. The link in this unique system comprises a number of substances whose task is to translate the signals. Among them, the gut regulatory peptides are considered to be substances that play a pivotal role in digestive functions. This review will deal with recent advances in the regulation of digestive functions in which the gut regulatory peptides are involved during development in calf i.e., during foetal life, after birth, during maintenance at the preruminant stage, and at weaning. This report will be devoted in particular to gut regulatory peptides as mediators of gastrointestinal (GI) growth, motility and development of secretion and adaptations. Increasing knowledge about the biological functions and mechanisms of gut regulatory peptide actions could help in managing the growth and maturation of the gastrointestinal tract (GTI), to better optimize digestive motility and productions. It is particularly important in the young to help them to better pass through such critical stages as the neonatal and weaning periods.

show abstract

“…In those reports, we found that increasing the intestinal leucine flux enhanced the synthesis and secretion of pancreatic α-amylase and further increased starch digestion in the small intestine. However, the potential influences of the surgery on pancreatic functions could not be ruled out (Ternouth and Buttle, 1973;Tiscornia et al, 1977;Zabielski and Pierzynowski, 2001;Ansia et al, 2019). Therefore, the current experiment 1 was to evaluate rumen-protected leucine (RP-Leu) supplementation for its ability to possibly improve small intestinal starch digestion in heifers without the confounding factor of surgery.…”

Section: Introductionmentioning

confidence: 99%

Decreased amylolytic microbes of the hindgut and increased blood glucose implied improved starch utilization in the small intestine by feeding rumen-protected leucine in dairy calves

Ren

Bai

et al. 2020

Journal of Dairy Science

View full text Add to dashboard Cite

Starch digestion in the small intestine in ruminants is relatively lower compared with that in monogastric animals, likely due to low pancreatic α-amylase secretion. Previous studies suggested that leucine could increase pancreatic α-amylase secretion in the small intestine of heifers cannulated with abomasal, duodenal, and ileal catheters. However, the surgical procedures probably have an effect on pancreatic function. Thus, we used rumen-protected leucine (RP-Leu) to explore its effect on small intestinal digestion of starch in calves without any surgery in 3 experiments. The first experiment was to explore whether RP-Leu could improve post-ruminal starch digestion in 5-mo-old calves (158 ± 19 kg body weight ± standard deviation). We found that RP-Leu did not affect rumen fermentation profile or wholetract starch digestibility, but it increased blood glucose concentration and fecal pH and decreased fecal propionate molar proportion. Additionally, RP-Leu increased fibrolytic genera Ruminiclostridium and Pseudobutyrivibrio and decreased the amylolytic genus of Faecalibacterium. The second experiment compared RP-Leu and rumen-protected lysine (RP-Lys) for their effects on post-ruminal starch digestion in 6-mo-old calves (201 ± 24 kg body weight). The responses of blood glucose concentration, fecal pH, fecal propionate proportion, and starch digestibility to RP-Leu supplementation were similar to those observed in experiment 1. Cellulolytic family Ruminococcaceae and Bacteroidales BS11 gut group tended to be increased by RP-Leu. In contrast, RP-Lys showed no significant influence on the above measurements. The third experiment determined the interaction between RP-Leu and rumen-escape starch (RES) on the small intestinal digestion of starch in 8-mo-old calves (289 ± 26 kg body weight). An interaction between RP-Leu and RES levels was observed in fecal butyrate concentration and the relative abundance of family Bacteroidaceae, and genera Ruminococcaceae UCG-005 and Bacteroides. We found that RP-Leu tended to increase the abundance of fecal Firmicutes and decrease Spirochaetae. In conclusion, RP-Leu, but not RP-Lys, increased blood glucose concentration and decreased the amount of starch fermented in the hindgut in a RES dose-dependent manner, suggesting that RP-Leu might stimulate starch digestion in the small intestine.

show abstract

Development and regulation of pancreatic juice secretion in cattle. State-of-the-art

Cited by 5 publications

References 37 publications

Regulation of pancreatic exocrine in ruminants and the related mechanism: The signal transduction and more

Regulation of pancreatic exocrine in ruminants and the related mechanism: The signal transduction and more

Gut regulatory peptides as mediators of gastrointestinal tract growth, motility and development of secretion in young ruminants

Decreased amylolytic microbes of the hindgut and increased blood glucose implied improved starch utilization in the small intestine by feeding rumen-protected leucine in dairy calves

Contact Info

Product

Resources

About