Development and regression of non-capillary vessels in the bovine corpus luteum

Bauer, Mario; Schilling, Nicole; Spanel-Borowski, K.

doi:10.1007/s00441-002-0640-x

Cited by 16 publications

(9 citation statements)

References 28 publications

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“…We still do not know the role of SMA-positive pericytes in the regulation of luteolysis. On the other hand, some researchers noted an appearance of non-capillary vessels with thickened wall in the regressing CL of various animals including cows [ 15 , 23 , 33 ], that show similar morphology to AVA-like vessels observed in this study.…”

Section: Discussionsupporting

confidence: 84%

“…The appearance of AVA-like vessels in the regressed bovine CL was previously reported by Höfliger [ 16 ]; in stages more than 25 days after ovulation, the CL consisted of crooked arteries with the characteristics of AVA. Bauer et al [ 33 ] also noted an increased number of non-capillary vessels with thickened vessel walls in the bovine CL. Hirschberg et al [ 34 ] more recently reported the existence of AVA-like arteries with thickened medial layers showing SMA immunoreactivity during the later luteal stage in cows; however, they reported that “the source of this abundance of vascular smooth muscle-like cells is presently not clear”.…”

Section: Discussionmentioning

confidence: 95%

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Histological analysis of arteriovenous anastomosis-like vessels established in the corpus luteum of cows during luteolysis

et al. 2016

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BackgroundThe mechanisms regulating the function and regression of the corpus luteum (CL) have not yet been elucidated in detail. The regressed CL of cows was previously reported to be filled with unusual vessels like arteriovenous anastomosis (AVA); however how these vessels are being established during luteolysis remains unknown.MethodsThe bovine CL at different luteal stages and regressing bovine CL induced by prostaglandin F2α (PGF) were histologically analyzed using light and electron microscopic levels. The changes in mRNA expression of genes encoding α-smooth muscle actin (SMA; Acta2) and transforming growth factor β1 (Tgfb1) in luteal tissues were analyzed by quantitative RT-PCR.ResultsAVA-like vessels appeared in the regressed CL with a diameter less than 1.5 cm in which no functional luteal cells and macrophages were observed. Epithelioid cells in the AVA-like vessel wall were immunoreactive for SMA, and the lumen of the vessels were narrow. Immunoreaction for SMA was found in the tunica media of typical arteries and arterioles, and pericytes around capillary vessel. Cells with elongated cytoplasmic processes ―resident fibroblasts expressing vimentin― distributed in the CL parenchyma without any association with blood vessels are also immunoreactive for SMA, and accumulated around arteries and arterioles during the late-luteal stage. In the regressed CL, walls of arteries and arterioles consisted of more than two layers of epithelioid cells positive for both SMA and desmin, suggesting that they are myofibroblasts transformed from fibroblasts. The percentage of the area positive for SMA and the mRNA expression of Acta2 were significantly increased in the regressed CL; however, they did not alter when a luteolytic dose of PGF was injected in vivo and collected within 24 h after the injection. On the other hand, Tgfb1, a known regulator for myofibroblast transformation, was significantly increased in PGF-induced regressing CL as well as in the CL during the late-luteal stage.ConclusionsSMA-positive myofibroblasts accumulates around the arteries and arterioles to form AVA-like vessels during luteolysis in cows. PGF indirectly regulates myofibroblast transformation through enhancing the expression of TGFβ1. These peculiar AVA-like vessels may be involved in the regulation of blood flow in the bovine CL during luteolysis.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 95%

Histological analysis of arteriovenous anastomosis-like vessels established in the corpus luteum of cows during luteolysis

et al. 2016

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“…1984). Furthermore, Bauer et al . (2003) have reported a formation of elastin fibers in arterial vessels of regressing bovine CLs.…”

Section: Discussionmentioning

confidence: 99%

DOES ELASTIN CONTRIBUTE TO THE PERSISTENCE OF CORPORA ALBICANTIA IN THE OVARY OF THE COMMON DOLPHIN (DELPHINUS DELPHIS)

Takahashi¹,

Ohwada²,

Watanabe³

et al. 2006

Marine Mammal Science

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The corpora albicantia (CAs) from the ovaries of 39 common dolphins (Delphinus delphis) caught in driving fisheries were used, and histologically and immunohistochemically examined. The area of each corpus albicans (CA) and the proportion of that area occupied by elastin were measured using NIH-image software. In all CAs, elastoid material (EM) was apparent although EM area varied in each CA. CAs increased in number with dolphin age. Smaller CAs contained a higher proportion of EM. EM was completely digested by elastase, but not by collagenase. Furthermore, EM was immunostained with anti-␣-elastin antibody. These results demonstrated that EM was elastin. The present study is the first to describe the presence of elastin 1 Current address: Biologging Institute, 2-31-10, Rex Yushima 301, Yushima Bunkyo-ku, Tokyo 113-0034, Japan. 819 820 MARINE MAMMAL SCIENCE, VOL. 22, NO. 4, 2006 in cetacean CAs. The higher proportion of elastin in small-sized CAs of common dolphins is suggested as the likely cause of the persistence of CA.

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“…The increase of VEGF144 during the functional luteolysis (day 17) leads to hypothesize that the conditions of metabolic stress and hypoxia (observed during this phase) are responsible for the up-regulation of this isoform, as previously demonstrated in murine ovarian cancer cells under glucose starvation (Zhang et al, 2002). A possible explanation for the presence of this isoform during early luteolysis, despite the reduction and loss of capillaries (Bacci et al, 1996;Lei et al, 1998;Gaytan et al, 1999), should be the conspicuous development of noncapillary vessels in order to assist the absorption of degenerated luteal mass (Reynolds and Redmer, 1998;Bauer et al, 2003).…”

Section: Discussionmentioning

confidence: 77%

Characterization and differential expression of vascular endothelial growth factor isoforms and receptors in swine corpus luteum throughout estrous cycle

Ribeiro

Bacci

Seren

et al. 2006

Molecular Reproduction Devel

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Corpus luteum (CL) undergoes growth and regression during each estrous cycle; these processes are accompanied by growth and regression of the luteal vascular bed. Vascular endothelial growth factor (VEGF) is the main regulator of angiogenesis, inducing endothelial cell proliferation, migration, vascular permeability, and vessel lumen formation. VEGF presents several isoforms that are produced by alternative splicing of the same mRNA transcript. We determined by real time RT-PCR the expression patterns of VEGF isoform and receptor mRNAs, as well as the VEGF protein levels in pig CL throughout a whole estrous cycle. Four novel VEGF isoforms (VEGF144, VEGF147, VEGF182, and VEGF164b) were found for the first time in swine and the seven identified isoforms can be grouped in four different patterns of expression. The most expressed splice variants were VEGF120 and VEGF164. All isoforms showed their highest mRNA levels in newly formed CLs (day 1), followed by a decrease during mid-late luteal phase (days 10-17), except for VEGF182, VEGF188 and VEGF144 that showed a differential regulation during late luteal phase (day 14) or at luteolysis (day 17). VEGF protein levels paralleled the most expressed and secreted VEGF120 and VEGF164 isoforms. The VEGF receptors mRNAs showed a different pattern of expression in relation to their ligands, increasing between day 1 and 3 and gradually decreasing during the mid-late luteal phase. The differential regulation of VEGF isoforms may suggest specific physiological roles for some of them, particularly in angioregression occurring during the apoptotic structural luteolysis.

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Development and regression of non-capillary vessels in the bovine corpus luteum

Cited by 16 publications

References 28 publications

Histological analysis of arteriovenous anastomosis-like vessels established in the corpus luteum of cows during luteolysis

Histological analysis of arteriovenous anastomosis-like vessels established in the corpus luteum of cows during luteolysis

DOES ELASTIN CONTRIBUTE TO THE PERSISTENCE OF CORPORA ALBICANTIA IN THE OVARY OF THE COMMON DOLPHIN (DELPHINUS DELPHIS)

Characterization and differential expression of vascular endothelial growth factor isoforms and receptors in swine corpus luteum throughout estrous cycle

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