Development and Prospects of Furin Inhibitors for Therapeutic Applications
Alexandre V. Ivachtchenko,
Alexander V. Khvat,
Dmitrii O. Shkil
Abstract:Furin, a serine protease enzyme located in the Golgi apparatus of animal cells, plays a crucial role in cleaving precursor proteins into their mature, active forms. It is ubiquitously expressed across various tissues, including the brain, lungs, gastrointestinal tract, liver, pancreas, and reproductive organs. Since its discovery in 1990, furin has been recognized as a significant therapeutic target, leading to the active development of furin inhibitors for potential use in antiviral, antibacterial, anticancer… Show more
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