Development and preclinical validation of 2-deoxy 2-[
18
F]fluorocellobiose as an
Aspergillus
-specific PET tracer
Swati Shah,
Jianhao Lai,
Falguni Basuli
et al.
Abstract:The global incidence of invasive fungal infections (IFIs) has increased over the past few decades, mainly in immunocompromised patients, and is associated with high mortality and morbidity.
Aspergillus fumigatus
is one of the most common and deadliest IFI pathogens. Major hurdles to treating fungal infections remain the lack of rapid and definitive diagnosis, including the frequent need for invasive procedures to provide microbiological confirmation, and the lack of specificity of struc… Show more
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