Development and Possibilities of Multichannel Voltammetric Detection in Liquid Chromatography

Abstract

Voltammetric detection in HPLC by using linear potential sweeps applied to dual electrode cells is evaluated. The application of an offset between both potential sweeps, applied to either serial or parallel setup of both working electrodes, and the further subtraction of the corresponding datasets are discussed. The use of multivariate curve resolution for the treatment of overlapping signals is also investigated. Despite some noise problems, mostly derived from the differences between the working electrodes, the proposed multichannel method appears to be promising. The different approaches are tested by analyzing some thiols mixtures.

Recent advances in analytical calibration with multi-way data

“…69,70 Finally, a few three-way electrochemical examples can be cited, reporting the determination of: (1) pesticides following the adsorption kinetics of stripping square wave voltammetry, 71 (2) lead in interfering samples from potential-pulse time data using differential pulse voltammetry, 72 and (3) thiols by liquid chromatography with linear potential sweep detection. 73 This field will certainly grow as rapid electrochemical techniques become available for chromatographic detection.…”