Development and pilot evaluation of a novel probiotic mixture for the management of seasonal allergic rhinitis

Koyama, Tara KoyamaT.; Kirjavainen, Pirkka V.; Fisher, C; Summers, Kelly; Hekmat, Sharareh; Reid, Gregor

doi:10.1139/w10-061

Cited by 37 publications

(22 citation statements)

References 23 publications

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“…A fourth study, testing an ad hoc mixture of L. rhamnosus GR-1 and Bifidobacterium adolescentis supplied in a yogurt, found no clinical effect in a group of adult patients with ragweed-induced allergic rhinitis. However, potential desirable effects were found in the cytokine profiles of these patients, albeit without a clinical symptom tie-in [105]. …”

Section: Probiotics and Respiratory Allergymentioning

confidence: 99%

Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper

Fiocchi

Burks

Bahna

et al. 2012

World Allergy Organization Journal

123

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BackgroundProbiotic administration has been proposed for the prevention and treatment of specific allergic manifestations such as eczema, rhinitis, gastrointestinal allergy, food allergy, and asthma. However, published statements and scientific opinions disagree about the clinical usefulness.ObjectiveA World Allergy Organization Special Committee on Food Allergy and Nutrition review of the evidence regarding the use of probiotics for the prevention and treatment of allergy.MethodsA qualitative and narrative review of the literature on probiotic treatment of allergic disease was carried out to address the diversity and variable quality of relevant studies. This variability precluded systematization, and an expert panel group discussion method was used to evaluate the literature. In the absence of systematic reviews of treatment, meta-analyses of prevention studies were used to provide data in support of probiotic applications.ResultsDespite the plethora of literature, probiotic research is still in its infancy. There is a need for basic microbiology research on the resident human microbiota. Mechanistic studies from biology, immunology, and genetics are needed before we can claim to harness the potential of immune modulatory effects of microbiota. Meanwhile, clinicians must take a step back and try to link disease state with alterations of the microbiota through well-controlled long-term studies to identify clinical indications.ConclusionsProbiotics do not have an established role in the prevention or treatment of allergy. No single probiotic supplement or class of supplements has been demonstrated to efficiently influence the course of any allergic manifestation or long-term disease or to be sufficient to do so. Further epidemiologic, immunologic, microbiologic, genetic, and clinical studies are necessary to determine whether probiotic supplements will be useful in preventing allergy. Until then, supplementation with probiotics remains empirical in allergy medicine. In the future, basic research should focus on homoeostatic studies, and clinical research should focus on preventive medicine applications, not only in allergy. Collaborations between allergo-immunologists and microbiologists in basic research and a multidisciplinary approach in clinical research are likely to be the most fruitful.

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Section: Probiotics and Respiratory Allergymentioning

confidence: 99%

Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper

Fiocchi

Burks

Bahna

et al. 2012

World Allergy Organization Journal

123

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“…In adult patients with seasonal allergic rhinitis, probiotics modulated immune responses; they have the potential to alleviate the severity of symptoms31). However, other studies showed that probiotics provided few clinical benefits and did not alleviate the symptoms or reduce the use of medication32,33).…”

Section: Clinical Efficacy Of Probiotics On Allergic Diseasesmentioning

confidence: 99%

Clinical efficacy and mechanism of probiotics in allergic diseases

Kim

Lee

et al. 2013

Korean J Pediatr

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A complex interplay between genetic and environmental factors partially contributes to the development of allergic diseases by affecting development during prenatal and early life. To explain the dramatic increase in the prevalence of allergic diseases, the hygiene hypothesis proposed that early exposure to infection prevented allergic diseases. The hygiene hypothesis has changed to the microbial hypothesis, in which exposure to microbes is closely linked to the development of the early immune system and allergic diseases. The intestinal flora may contribute to allergic disease through its substantial effect on mucosal immunity. Based on findings that exposure to microbial flora early in life can change the Th1/Th2 balance, thus favoring a Th1 cell response, probiotics may be beneficial in preventing allergic diseases. However, evidence from clinical and basic research to prove the efficacy of probiotics in preventing allergy is lacking. To date, studies have yielded inconsistent findings on the usefulness of probiotics in allergic diseases. It is difficult to demonstrate an exact effect of probiotics on asthma, allergic rhinitis, and food allergy because of study limitations, such as different first supplementation period, duration, different strains, short follow-up period, and host factors. However, many studies have demonstrated a significant clinical improvement in atopic dermatitis with the use of probiotics. An accurate understanding of the development of human immunity, intestinal barrier function, intestinal microbiota, and systemic immunity is required to comprehend the effects of probiotics on allergic diseases.

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“…For instance, Lactobacillus paracasei-33 caused increase in quality of life parameters, Bifidobacterium longum BB536 caused relief in rhinorrhea, nasal blockage and composite scores, and reduction in ocular and nasal symptoms in Japanese cedar pollinosis, Lactobacillus gasseri altered serum IgE concentration, Lactobacillus casei DN-1 14 001 reduced number of AR episodes in children with AR [82]. However, others showed little clinical benefit of probiotics use [83]. Insufficient and non-robust data available so far clearly warrants further research to support use of probiotics in the treatment of AR.…”

Section: Capsaicin Desensitization Complementary Alternative Treatmmentioning

confidence: 99%

Allergic rhinitis: An update on disease, present treatments and future prospects

Mandhane¹,

Shah²,

Thennati³

2011

International Immunopharmacology

109

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Development and pilot evaluation of a novel probiotic mixture for the management of seasonal allergic rhinitis

Cited by 37 publications

References 23 publications

Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper

Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper

Clinical efficacy and mechanism of probiotics in allergic diseases

Allergic rhinitis: An update on disease, present treatments and future prospects

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